Optical coherence tomography – current and future applications

Adhi, Mehreen; Duker, Jay S.

doi:10.1097/icu.0b013e32835f8bf8

Cited by 491 publications

(358 citation statements)

References 64 publications

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“…The method, which is based on low coherence interferometry, was first presented by Huang et al [18]. In medicine, OCT is currently primarily used in ophthalmology for evaluating the pathological changes in retinal layers and the optic nerve [19][20][21][22]. Further applications are found in dermatology [23,24] and cardiology [25].…”

Section: Introductionmentioning

confidence: 99%

Dental Applications of Optical Coherence Tomography (OCT) in Cariology

et al. 2017

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Across all medical disciplines, therapeutic interventions are based on previously acquired diagnostic information. In cariology, which includes the detection and assessment of the disease "caries" and its lesions, as well as non-invasive to invasive treatment and caries prevention, visual inspection and radiology are routinely used as diagnostic tools. However, the specificity and sensitivity of these standard methods are still unsatisfactory and the detection of defects is often afflicted with a time delay. Numerous novel methods have been developed to improve the unsatisfactory diagnostic possibilities in this specialized medical field. These newer techniques have not yet found widespread acceptance in clinical practice, which might be explained by the generated numerical or color-coded output data that are not self-explanatory. With optical coherence tomography (OCT), an innovative image-based technique has become available that has considerable potential in supporting the routine assessment of teeth in the future. The received cross-sectional images are easy to interpret and can be processed. In recent years, numerous applications of OCT have been evaluated in cariology beginning with the diagnosis of different defects up to restoration assessment and their monitoring, or the visualization of individual treatment steps. Based on selected examples, this overview outlines the possibilities and limitations of this technique in cariology and restorative dentistry, which pertain to the most clinical relevant fields of dentistry.

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Section: Introductionmentioning

confidence: 99%

Dental Applications of Optical Coherence Tomography (OCT) in Cariology

et al. 2017

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“…However, efforts are underway to provide automated choroidal thickness maps, similar to automated retinal thickness maps currently available, particularly with the coming next-generation OCT systems. 55 In conclusion, we observed that Sattler's medium vessel layer was disproportionately enlarged in sarcoid compared with TB-related uveitis, and there is a trend for the choroid to be thicker in active granulomatous uveitis. In addition, choroidal thinning was observed to be associated with reduced VA.…”

Section: The Choroid In Granulomatous Uveitismentioning

confidence: 56%

Structural changes of the choroid in sarcoid- and tuberculosis-related granulomatous uveitis

Mehta

Sim

Keane

et al. 2015

Eye

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Aim The aim of this study is to characterise the choroidal features of patients diagnosed with sarcoid-and tuberculosis (TB)-associated granulomatous uveitis using spectral domain optical coherence tomography (OCT). Methods Twenty-seven patients (27 eyes) diagnosed with sarcoid-(13 eyes) and TB (14 eyes)-related uveitis were included in this retrospective, cross-sectional study. Over a sixmonth period, patients diagnosed with sarcoid and TB granulomatous uveitis were scanned using enhanced depth imaging OCT. Clinical and demographical characteristics were recorded, including the method of diagnosis, disease activity, site of inflammation (anterior or posterior), treatments, and visual acuity (VA). Manual segmentation of the choroidal layers was performed using custom image analysis software. Results The main outcome measure was OCT-derived thickness measurements of the choroid and choroidal sublayers (Haller's large vessel and Sattler's medium vessel layers) at the macula region. The ratio of Haller's large vessel to Sattler's medium vessel layer was significantly different at the total macula circle in eyes diagnosed with TB uveitis (1.47 ( = 140.71/95.72 μm)) compared with sarcoid uveitis (1.07 ( = 137.70/128.69 μm)) (P = 0.001). A thinner choroid was observed in eyes with a VA ≥ 0.3 LogMAR (Snellen 6/12; 198.1 μm (interquartile range (IQR) = 147.0-253.4 μm) compared with those with VA o0.3 LogMAR (292.4 μm (IQR = 240.1-347.6 μm)) at the total macula circle (P = 0.004). At the foveal central subfield, the median choroidal thickness was 336.8 μm (IQR = 272.3-375.4 μm) in active compared with 239.3 μm (IQR = 195.3-330.9 μm) in quiescent disease (P = 0.04). Conclusion A disproportionately enlarged Sattler's layer may indicate a diagnosis of sarcoid-related uveitis, and choroidal thickening may be a feature of active granulomatous uveitis.

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“…The OCT system is composed of a light source (ultra-short pulsed laser, super continuum laser or super luminescent diode), an interferometer, and a microscope that delivers light and collects reflection from the tissues analyzed. OCT is a technique for imaging tissues and cells in living organisms and is a diagnostic method that is widely used in cardiology [73], ophthalmology [74], dermatology [75], and also in other medical domains such as dentistry [76].…”

Section: The Use In Imagerymentioning

confidence: 99%

The Laser Technology: New Trends in Biology and Medicine

Legrès¹,

Chamot²,

Varna³

et al. 2014

JMP

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In fifty years, laser technology has made great progress, and its many applications make it essential in everyday life. However, this technology is still open to numerous developments. Across multiple applications, there is particular focus in the field of medicine, for diagnosis for tailored therapies, and as a research tool in biology. Whereas its use is now well-demonstrated in ophthalmologic and dermatologic treatments, and surgery, one of the most fascinating aspects of laser technology in the field of biology emerged in the late 1990s with the development of devices able to perform fine dissections of biological tissues using a laser beam. The so-called laser-associated microdissection offers a rapid, precise method of isolating and removing targeted cells or groups of cells from complex biological tissues. It represents the missing link between clinical observations and the intrinsic physiological mechanisms of biological tissues. The molecular examination of pathologically altered cells and tissues for DNA, RNA, and protein expression has revolutionized research and diagnosis in pathology, enabling assessment of the role of the cell type in the normal physiological or disease process. Alongside conventional diagnostic and therapeutic approaches, another field of application contribute to the development of targeted treatments at the nanoscale level of laser technology, mainly in the field of cancer, leading to design new and innovative strategies in drug delivery and image-guided surgery. Most of these approaches, but although not exhaustively, will be presented here.

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Optical coherence tomography – current and future applications

Cited by 491 publications

References 64 publications

Dental Applications of Optical Coherence Tomography (OCT) in Cariology

Dental Applications of Optical Coherence Tomography (OCT) in Cariology

Structural changes of the choroid in sarcoid- and tuberculosis-related granulomatous uveitis

The Laser Technology: New Trends in Biology and Medicine

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