Optical Coherence Tomography Assessment of In Vivo Vascular Response After Implantation of Overlapping Bare-Metal and Drug-Eluting Stents

Abstract

As assessed by OCT the impact of DES on vascular healing was similar at overlapping and nonoverlapping sites. However, strut malapposition, coverage pattern, and neointimal hyperplasia differ significantly according to DES type. (Optical Coherence Tomography for Drug Eluting Stent Safety [ODESSA]; NCT00693030).

Time course of vascular response after an a priori strategy of bare metal stent implantation post-dilated with a paclitaxel-coated balloon: Implementation of a three-dimensional analysis algorithm with optical coherence tomography

“…With respect to the standard deviation of our results, duration of dual antiplatelet therapy below 6 should be avoided. Stent coverage after a BMS + PCB approach is similar to those of paclitaxel-and sirolimus-eluting stents after 6 months (~5-8% uncovered struts) [6,9,15,16]. However, newer generation everolimus-and zotarolimus-eluting stents seem to have a better (0.1 ± 0.4% after 6 months) and faster stent endothelialization (4.7 ± 5.7-6.2 ± 6.9% after 3 months) [15,17].…”

Resolute Integrity drug eluting stent safety and efficacy for the treatment of coronary artery disease

“…Six cases of late incomplete apposition were noted at 9-month follow-up with intravascular ultrasound, but only one required a TLR at 280 days. Guagliumi et al 26 have also described the presence of a higher rate of late incomplete apposition with R-ZES stents, through the use of OCT. Late incomplete apposition is a phenomenon potentially associated with late ST, but this has not been conclusively demonstrated.…”

“…In the LongOCT study, 26 the vascular response to R-ZES, the ZES with prolonged drug release, was evaluated in vivo and compared with E-ZES, a ZES with faster kinetics, by means of OCT. The study had a pool of 43 patients, of which 21 were treated with "slow-release" ZES and 22 patients were treated with "fast-release" ZES.…”

“…Along with angiography and intravascular ultrasound, OCT has been used in vivo to evaluate the vascular response to stents, and, according to Guagliumi et al, 26 the differences found between the R-ZES and E-ZES were based on different release kinetics, with the R-ZES showing slow release and the E-ZES a fast-release kinetic. The OCT showed more suppression of NIH with the R-ZES arm versus the E-ZES but a higher proportion of patients with uncovered and malapposed struts at 6-month follow-up.…”

‘Go with the flow ’: A review of methods and advancements in blood flow imaging

“…psoriasis [318]; assessment of arteriosclerotic plaques [319,320]; and determining burn extent and tissue viability by defining tissue barrier layers characteristic of scarring (wound healing and graft flow) [321][322][323]. However, in truth, OCT has ubiquitous applications, having emerged in a variety of clinical fields: ophthalmology [324][325][326], intravascular imaging in cardiology [327,328], oncology [329,330], gastroenterology [331][332][333], general dermatology [334][335][336], dentistry [337,338], and gynaecology [339,340], to name a few. Functional extensions of OCT have emerged: polarisation-sensitive systems used, for example, in the diagnosis of neoplastic 6 processes; differential phase-sensitive methods for use in photorefractive surgery; full-field advancement of the conventional single-point OCT detection technique; and endoscopic OCT.…”