Optical Coherence Tomography Angiography to Estimate Retinal Blood Flow in Eyes with Retinitis Pigmentosa

Sugahara, Masako; Miyata, Manabu; Ishihara, Kenji; Gotoh, Noriko; Morooka, Shigenori; Ogino, Ken; Hasegawa, Tomoko; Hirashima, Takako; Yoshikawa, Munemitsu; Hata, Masaharu; Muraoka, Yuki; Ooto, Sotaro; Yamashiro, Kenji; Yoshimura, Nagahisa

doi:10.1038/srep46396

Cited by 54 publications

(76 citation statements)

References 28 publications

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“…Further research in patients with BCD at various stages is necessary to clarify when the deficit in blood flow to the choriocapillaris commences. We could not investigate the study parameters in 17% of eyes; however, this rate is similar to that reported previously for OCTA with the same Avanti system in patients with RP (38%) 15. The low image quality is due to poor fixation in patients with BCD and RP with low visual function.…”

Section: Discussionsupporting

confidence: 60%

Choriocapillaris flow deficit in Bietti crystalline dystrophy detected using optical coherence tomography angiography

et al. 2017

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Section: Discussionsupporting

confidence: 60%

Choriocapillaris flow deficit in Bietti crystalline dystrophy detected using optical coherence tomography angiography

et al. 2017

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“…In addition, the clarity of the images of the choroidal vascular layer was dependent on the status of the RPE, which was affected by the stage of RP. 8 In addition to the original images, binarized images and skeletonized images were obtained by the Angio Exerciser software, which was provided by Zeiss for research purposes only. The perfusion density (PD) was calculated as the percentage of the area occupied by vessels in the designated 3 3 3-mm area based on the binarized images.…”

Section: 13mentioning

confidence: 99%

Quantification of Macular Microvascular Changes in Patients With Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

Inooka

Ueno

Kominami

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To evaluate the microvascular changes in eyes with RP quantitatively using optical coherence tomography angiography (OCTA) and to determine whether the correlations between these indices and the severity of RP are significant.METHODS. This was a retrospective, observational study. The medical records of 53 RP patients and 46 controls were reviewed. The OCTA images were obtained with the Cirrus 5000 with Angioplex, and an automated program was used to analyze the microvascular patterns. The perfusion density (PD) and vessel length density (VLD) were used as indices of the microvascular density, whereas the vessel diameter index (VDI) was used as a measure of the caliber of the vessels. The width of the ellipsoid zone (EZ) in the OCT images and the mean deviation (MD) of the Humphry Field Analyzer (HFA) were used to determine the severity of the RP. Student's t-tests and Spearman's correlation tests were used.RESULTS. Both the PD and VLD in the superficial and deep plexuses and the whole retina were significantly reduced, and the VDI was significantly increased in RP patients compared with the corresponding values of the controls (P < 0.001). Spearman's rank tests indicated the RP severity was significantly correlated with the PD and VLD in all three layers (P < 0.001, r ranging from 0.50 to 0.87) and significantly correlated with VDI in the deep and the whole retina (P < 0.001, ranging from À0.64 to À0.73).CONCLUSIONS. Quantitative changes in the microvascular density might be useful for examining the pathophysiology of RP.

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“…A quantitative analysis also found a significant reduction in superficial and deep vascular density among RP patients, and an enlargement of FAZ when compared to the normal controls (Sugahara et al. ). However, no study so far has reported the comparison between OCTA and CDFI methods.…”

Section: Discussionmentioning

confidence: 94%

“…; Sugahara et al. ). However, no study so far has reported the comparison between the two methods and the relationship between the changes in retinal large vessels and terminal vessels.…”

Section: Introductionmentioning

confidence: 96%

Quantitative evaluation of primary retinitis pigmentosa patients using colour Doppler flow imaging and optical coherence tomography angiography

Wang

Zhao

et al. 2019

Acta Ophthalmologica

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Purpose To find the potential relation between changes in retinal large vessels and terminal vessels using colour Doppler flow imaging (CDFI) and optical coherence tomography angiography (OCTA) and to compare the respective advantages of CDFI and OCTA in evaluating vascular changes in retinitis pigmentosa (RP) patients. Methods A prospective series of case study was conducted to enrol RP patients and age‐matched controls, who were, respectively, imaged by CDFI and OCTA. Repeatability and reproducibility of both CDFI and OCTA were performed among healthy volunteers. The central retinal artery (CRA) was detected by CDFI analysis to provide parameters of peak systolic velocity (PSV), end‐diastolic velocity (EDV) and time‐averaged maximum velocity (TAMV). Retinal parameters were evaluated from OCTA images, including vascular area density (VAD) of the superficial vascular layer, the fovea avascular zone (FAZ) area and retinal thickness. RP patients were separated into a high‐vision group and a low‐vision group, according to median vision (0.3, LogMAR 0.5). Multiple comparisons were used to analyse the data between groups. A correlation analysis was used to determine the correlation between CDFI and OCTA parameters. Results Twenty RP patients (40 eyes) and thirteen normal volunteers (26 eyes) were enrolled in this study. Repeatability and reproducibility of the measurements by CDFI had higher CVs, from 4.5% to 15.4%, than those measurements by OCTA (<5%). All the CDFI and OCTA parameters examined had significant reductions in RP patients compared to those in the controls (p < 0.01). Compared to the high‐vision group, the low‐vision group exhibited a statistically significant decrease in vascular parameters of the FAZ area, fovea VAD and parafovea nasal side VAD (p < 0.05); as well as in the parameters of the fovea thickness, and the parafovea nasal, superior and inferior side thickness (p < 0.05). From the correlation analysis, a significant association was found between the vision and CDFI parameters (PSV and time‐averaged maximum velocity (TAMX), p < 0.05), and the vision and OCTA parameters (FAZ area, fovea and nasal side VAD, retinal thickness in all sides, p < 0.05). PSV and TAMX of the CRA were closely related to the OCTA superficial VAD in all sides, whereas the CDFI parameters showed poor correlation with retinal thickness. Conclusions Colour Doppler flow imaging (CDFI) and OCTA parameters revealed a significant reduction in RP patients when compared to the controls. OCTA can detect vision‐related microvascular and thickness changes around the macula between high‐ and low‐vision groups, which happen earlier than the changes in large vessels. In addition to good repeatability and reproducibility, OCTA may have significant utility in the diagnosis and monitoring of disease progression in RP patients.

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Optical Coherence Tomography Angiography to Estimate Retinal Blood Flow in Eyes with Retinitis Pigmentosa

Cited by 54 publications

References 28 publications

Choriocapillaris flow deficit in Bietti crystalline dystrophy detected using optical coherence tomography angiography

Choriocapillaris flow deficit in Bietti crystalline dystrophy detected using optical coherence tomography angiography

Quantification of Macular Microvascular Changes in Patients With Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

Quantitative evaluation of primary retinitis pigmentosa patients using colour Doppler flow imaging and optical coherence tomography angiography

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