Optical Coherence Tomography Angiography Quantitative Assessment of Choriocapillaris Blood Flow in Central Serous Chorioretinopathy

Rochepeau, Cédric; Kodjikian, Laurent; Garcia, Max-Adrien; Mathis, Thibaud

doi:10.1016/j.ajo.2019.01.014

Cited by 26 publications

(64 citation statements)

References 5 publications

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“…Similarly, our study demonstrated that FSV in unaffected eyes of CCSC were higher than those in healthy individuals, and remained statistically unchanged over time. As proposed by Nicolo, M. 19 , these CC alterations in asymptomatic eyes might be in the early stage of the same condition of CSC 2,11,19 . Previous studies have also detected punctated hyperfluorescent spots using ICGA in most contralateral eyes of CSC and PCV, which might be a subclinical manifestation of increased choroidal hypermeability and intrachoroidal hydrostatic pressure 17,22 .…”

Section: Discussionmentioning

confidence: 68%

“…Several OCTA-related studies have reported irregular flow patterns of CC in patients with CSC, including CC dilatation with increased flow signal 9,10 , and focal or defused dark areas with flow signal void (FSV) 7,9 , which were associated with the changes in ICGA. Various binary quantifications of OCTA imaging with objective data on various parameters have further confirmed these conclusions of CC attenuation in CSC 8,11,12 . Previously, we have qualitatively documented that 97% (32/33) of eyes diagnosed with CCSC return to exhibiting relatively normal distribution of fine particles in CC layer of OCTA at 3-month follow-up after half-dose PDT 13 .…”

Section: Introductionmentioning

confidence: 61%

“…It has been postulated that CSC may be an ocular condition caused by a systemic disease that involves choroidal circulation 1 , which could be potentially supported by previous results of some systemic risk factors 1 and abnormalities of CC and SFCT in self-resolved CSC eyes and the unaffected eyes 11,[19][20][21] . Similarly, our study demonstrated that FSV in unaffected eyes of CCSC were higher than those in healthy individuals, and remained statistically unchanged over time.…”

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

“…Using OCTA, quantitative analysis with automatic binarization methods has been increasingly employed to analyze CC flow changes in some chorioretinal disorders, such as dry age-related macular degeneration and CSC, providing reproducible and objective data 7,8,11 . Excluding the masking artifacts of SRF and RPE clumping and PED could help increase the reliability of the quantitative assessment in resolved CSC 2,11 . In previous studies, assessment of CC flow alterations in affected eyes showed a recovery of CC flow after the treatment of PDT 7,13,14,16 , which was consistent with our results of the reduced value of FSV at 6-m follow-up compared to 1-m follow-up.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA

Liu

Chen²,

et al. 2020

Preprint

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Background: To quantify flow changes in choriocapillaris (CC) in patients with chronic central serous chorioretinopathy (CCSC) in the treatment of half-dose photodynamic therapy (PDT) using optical coherence tomography angiography (OCTA) . Methods : A total of 28 affected eyes and 24 unaffected eyes of 26 CCSC patients receiving half-dose PDT, and 40 eyes of 20 healthy gender- and age-matched subjects were retrospectively enrolled. Proportion of total areas of flow signal voids ( FSV , %) in CC level of OCTA were mainly assessments in both eyes of the CCSC patients at baseline and repeated in multiple sections at 1-week, 1-month, 3-month and 6-month intervals after PDT. In addition , CC patterns in response to PDT at early stage and their subsequent morphologic changes were qualitatively documented using OCTA. Results: For affected eyes, significant decrease in FSV was found at 6-m follow-up than 1-m follow-up (p=0.036). Comparing to normal control eyes, FSV in affected eyes was significantly higher at 1-m, 3-m and 6-m follow-up (p<0.05 for all), while FSV in unaffected eyes was significantly higher at baseline, 1-w, 1-m and 3-m follow-up (p<0.05 for all). Three CC patterns of early response to PDT can be identified, including signs of recovery with more even flow signals, transient appearance of worsen ischemia and secondary neovascularization within CC level. Conclusion: Abnormal CC flow attenuation remained in completely resolved eyes of CCSC patients treated with half-dose PDT. Key Words: Chronic; Central Serous Chorioretinopathy; Optical Coherence Tomography Angiography; Photodynamic Therapy

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA

Liu

Chen²,

et al. 2020

Preprint

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Quantitative Analysis of the Choriocapillaris in Uveitis Using En Face Swept-Source Optical Coherence Tomography Angiography

Chu

Weinstein

Wang

et al. 2020

American Journal of Ophthalmology

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Purpose: To perform a quantitative analysis of choriocapillaris (CC) flow deficits (FDs) in patients with uveitis. Design: Retrospective cross-sectional studyMethods: Swept-source optical coherence tomography based angiography (SS-OCTA) macular volume scans (3×3 mm and 6×6 mm) were obtained using the PLEX® Elite 9000: En face CC images were generated and analyzed using an automated flow deficit identification algorithm. Three quantitative metrics were determined for each eye: FD number (FDN), mean FD size (MFDS), and FD density (FDD). Quantitative metrics were compared between uveitis and control eyes. The uveitis cohort was further subdivided by the presence or absence of choroidal involvement, and quantitative metrics were compared between subgroups and normal controls Results: A total of 38 eyes from 38 controls and 73 eyes from 73 uveitis subjects were included in this study. Eyes with uveitis have significantly larger CC MFDS (3×3 mm, p<0.0001; 6×6 mm, p<0.0001) and higher FDD (p=0.0002; p=0.0076) when compared to control eyes. Additional analysis determined that these differences are due to the choroidal disease subgroup, which demonstrates significantly larger MFDS (3×3 =1108 μm 2 ; 6×6 =1104 μm 2 ) compared to both normal controls (752 μm 2 , p<0.0001; 802 μm 2 , p<0.0001) and uveitis patients without choroidal involvement (785 μm 2 , p<0.0001; 821 μm 2 , p<0.0001). No significant differences were found between the quantitative metrics of controls and patients without choroidal involvement.Conclusions: Automated quantification of CC can identify pathological FDs and provide quantitative metrics describing such lesions in patients with uveitis. Posterior uveitis patients have significantly larger CC FDs than patients with other forms of uveitis.

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Validation of a Compensation Strategy Used to Detect Choriocapillaris Flow Deficits Under Drusen With Swept Source OCT Angiography

Shi

Chu

Wang

et al. 2020

American Journal of Ophthalmology

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Optical Coherence Tomography Angiography Quantitative Assessment of Choriocapillaris Blood Flow in Central Serous Chorioretinopathy

Cited by 26 publications

References 5 publications

Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA

Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA

Quantitative Analysis of the Choriocapillaris in Uveitis Using En Face Swept-Source Optical Coherence Tomography Angiography

Validation of a Compensation Strategy Used to Detect Choriocapillaris Flow Deficits Under Drusen With Swept Source OCT Angiography

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