Optical Coherence Tomography Angiography Quantitative Assessment of Exercise-Induced Variations in Retinal Vascular Plexa of Healthy Subjects

Kim, Sétha Vo; Semoun, Oudy; Pedinielli, Alexandre; Jung, Camille; Mière, Alexandra; Souied, Eric H.

doi:10.1167/iovs.18-24389

Cited by 36 publications

(26 citation statements)

References 42 publications

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“…Although autoregulatory mechanisms in the retina tend to maintain a constant blood flow over a wide range of perfusion pressures, blood flow can decrease beyond the compensation range 23 , 24 . Previous studies in adults showed that macular perfusion decreases in the superficial retinal layer after exercise, and that VD remains stable in the deep layer 6 , 20 . This discrepancy between the variation trend of RVD in superficial and deep layers after exercise may be attributable to differences in the elasticity and hardness of the fundus vessels between children and adults, which may lead to differences in autoregulatory ability 17 .…”

Section: Discussionmentioning

confidence: 93%

“…Alnawaiseh et al 10 reported that peripapillary and parafoveal flow densities decreased significantly after exercise. Vo Kim et al 6 also reported that the vessel density (VD) at the level of the retinal superficial layer, from 3 μm below the internal limiting membrane (ILM) to 15 μm below the inner plexiform layer (IPL), were decreased after exercise while the fractal dimension in the retinal deep layer, from 15 to 70 μm below the IPL, were significantly increased. Hayashi et al 7 found that the blood flow and vascular conductance of retinal arterioles remained stable while ocular blood flow increased in the retina and choroid during physical exercise.…”

Section: Introductionmentioning

confidence: 97%

“…Some previous studies have investigated the associations between exercise-induced alterations in the systemic circulation and changes in the retina and choroid in adults, but the results have been controversial 6 – 10 . Alnawaiseh et al 10 reported that peripapillary and parafoveal flow densities decreased significantly after exercise.…”

Section: Introductionmentioning

confidence: 99%

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Effects of physical exercise on macular vessel density and choroidal thickness in children

Pan

et al. 2021

Sci Rep

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We used swept-source (SS) optical coherence tomography (OCT) and OCT angiography (OCTA) to investigate the effects of moderate physical exercise on retinal and choroidal vessel densities (VDs) and thicknesses in children. One eye in each of 40 myopic children (mean age, 11.70 years) and 18 emmetropic children (mean age, 11.06 years) were included. SS-OCT 6 × 6-mm radial scans and SS-OCTA 3 × 3-mm images were centered on the macula. Heart rate (HR), systolic and diastolic blood pressure, and intraocular pressure (IOP) were recorded before and immediately after a 20-min stationary cycling exercise and after a 30-min rest. The subfoveal choroidal thickness (SFCT), choroidal thickness (CT), and VD at the superficial and deep retinal layers, choriocapillaris, and deeper choroidal vessels were determined. SFCT and CT were significantly lower at all locations immediately after exercise (p < 0.001) and did not fully recover after rest (p < 0.05). VD was lower in the deep retinal layer after exercise (p = 0.02) and higher in the superficial layer after rest (p = 0.03) in myopic eyes while it was higher in the superficial (p < 0.01) and deep layer (p < 0.01) after rest in emmetropic eyes. No significant exercise-related changes in the superficial retinal VD, choroidal VD, or IOP were observed. ΔCT% and ΔSFCT% were significantly correlated with increases in HR in myopic group (p = 0.04 and p = 0.03, respectively). Exercise increased retinal VD after rest in emmetropic eyes, and caused significant CT thinning that lasted for at least 30 min in both emmetropic and myopic eyes.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Effects of physical exercise on macular vessel density and choroidal thickness in children

Pan

et al. 2021

Sci Rep

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“…Physiological changes of the retina due to physical exercise Recently, Vo Kim et al showed that in employing OCT angiography in young individuals, a reduction of vessel density can be observed in the superficial vascular plexus of the macula, most possibly due to an increase in intraocular pressure during exercise [7]. At the same time, the fractal dimension of the deep capillary network increased after exercise, suggesting vascular recruitment.…”

Section: Physiological Changes Of the Fundus Circulation Due To Physimentioning

confidence: 99%

The Effect of Physical Exercise on the Retina and Choroid

Szalai

Pálya

Csorba

et al. 2020

Klin Monatsbl Augenheilkd

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There is only limited information available on the effects of physical exercise on the posterior pole. Retinal circulation is autoregulated similarly to the brain vasculature in order to provide constant flow and thus constant nutrition of the inner retinal structures while the choroid is mostly controlled by the sympathetic nervous system. The available data show that physical exercise may indeed have a positive effect on the retina and visual function. The assessment of retinal structure could serve as a marker in sports medicine, whereas physical activity could exert a positive protective effect against diseases such as diabetic retinopathy or age-related macular degeneration. According to our theory, similar to the term “trained heart” used in cardiology and sports medicine, the term “trained eye” could also be coined. This latter term would help to further emphasize the beneficial effects of physical exercise that works protectively not only for the cardiovascular but for the visual system as well, and thus could further help in the fight against avoidable blindness worldwide.

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“…In der Auswertung lag nicht von allen Patienten ein mit der OCT-A-Messung zeitgleich erhobener Blutdruckwert vor, sodass für eine statistische Auswertung des Blutdrucks als Confounder die Fallzahl nicht ausreichte. In einer anderen Arbeit wurde jedoch belegt, dass der Blutdruck zum Zeitpunkt der Messung keinen direkten Einfluss auf das Messergebnis der FAZ hat [49]. In unserer Arbeit ist aber trotzdem sichergestellt, dass keiner der Probanden vasoaktive Medikamente eingenommen hat oder dass eine vaskuläre Grunderkrankung, wie z.…”

Section: Diskussionunclassified

Verändert sich die foveale avaskuläre Zone beim Glaukom?

Lommatzsch

Heinz

Koch

et al. 2020

Klin Monbl Augenheilkd

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Zusammenfassung Hintergrund Vergleichende Beurteilung der fovealen avaskulären Zone (FAZ) mit ihrem Umfang und dem Azirkularitätsindex (AI) sowie der umgebenden Vessel Density bei Glaukomaugen im Vergleich zu gesunden Augen mit zusätzlicher Unterteilung nach Gesichtsfelddefekten an verschiedenen Stellen (zentral oder peripher). Material und Methoden Insgesamt wurden die Daten von 128 Augen ausgewertet. Dabei wurden zunächst Glaukomaugen (n = 74) mit gesunden Augen (n = 54) verglichen und im Weiteren Glaukomaugen mit einem zentralen Gesichtsfeldausfall (ZGD, n = 19) von Augen mit einem peripheren Gesichtsfelddefekt (PGD, n = 34) unterschieden. Die FAZ-Fläche, ihr Umfang und die Rundheit sowie die parafoveale Vessel Density (VD) wurden mittels der optischen Kohärenztomografie-Angiografie im oberflächlichen und tiefen Gefäßplexus berechnet. Ergebnisse Glaukomaugen haben im Vergleich zu gesunden Augen keine signifikante Veränderung der FAZ, ihres Umfangs oder der Zirkularität der avaskulären Zone. Unterteilt man jedoch die Glaukomaugen anhand der Gesichtsfeldausfälle, zeigt sich zum einen, dass die Augen mit einem zentralen Ausfall eine signifikant größere FAZ haben als die mit peripheren Ausfällen und dass der Umfang ebenfalls signifikant größer ist. Zum anderen zeigt der AI keinen signifikanten Unterschied in Abhängigkeit von der Lokalisation der Gesichtsfelddefekte. Die makuläre/foveale Vessel Density wird signifikant geringer bei der ZDG-Gruppe. Schlussfolgerungen Im Rahmen einer Glaukomerkrankung vergrößert sich die foveale avaskuläre Zone, wenn eine Zentralisierung des Gesichtsfelddefektes vorliegt und die Vessel Density nimmt im Bereich der Makula signifikant ab.

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Optical Coherence Tomography Angiography Quantitative Assessment of Exercise-Induced Variations in Retinal Vascular Plexa of Healthy Subjects

Abstract: Citation: Vo Kim S, Semoun O, Pedinielli A, Jung C, Miere A, Souied EH. Optical coherence tomography angiography quantitative assessment of exercise-induced variations in retinal vascular plexa of healthy subjects.

Cited by 36 publications

References 42 publications

Effects of physical exercise on macular vessel density and choroidal thickness in children

Effects of physical exercise on macular vessel density and choroidal thickness in children

The Effect of Physical Exercise on the Retina and Choroid

Verändert sich die foveale avaskuläre Zone beim Glaukom?

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