Optical Coherence Tomography Angiography in Retinal Vein Occlusion: Evaluation of Superficial and Deep Capillary Plexa

Coscas, Florence; Glacet–Bernard, A.; Mière, Alexandra; Caillaux, Violaine; Uzzan, J.; Lupidi, Marco; Coscas, G.; Souied, Eric H.

doi:10.1016/j.ajo.2015.10.008

Cited by 280 publications

(214 citation statements)

References 33 publications

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“…35,36 Finally, it could also result from shadowing or edema-related signal artifacts. 33,36,37 Here, the causal relationship between edema formation and deep plexus alteration was possibly indicated by the stronger correlation of CMT (and CMT change) with deep plexus changes, assessed by grading, vascular density, and local fractal dimension, than with superficial plexus changes (see Table 4). Importantly, this effect was controlled after statistical adjustment in the multivariate analysis, indicating that deep plexus abnormalities influence visual acuity independently from the presence of edema.…”

Section: Discussionmentioning

confidence: 93%

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

Matet

Daruich

Zografos

2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To analyze microvascular and structural changes in radiation maculopathy and their influence on visual acuity (VA), using optical coherence tomography (OCT) and OCT angiography (OCTA).METHODS. This was a retrospective analysis of consecutive patients with radiation maculopathy, 12 months or more after proton-beam irradiation for uveal melanoma, imaged with fluorescein angiography, OCT, and OCTA. Clinical parameters potentially affecting VA were recorded, including OCTA-derived metrics: foveal avascular zone (FAZ) area, vascular density, and local fractal dimension of the superficial (SCP) and deep capillary plexuses (DCP). Nonirradiated fellow eyes served as controls. RESULTS.Ninety-three patients were included. FAZ was larger, while SCP/DCP capillary density and local fractal dimension were lower in the 35 irradiated than in the 35 fellow eyes (P < 0.0001). Microvascular alterations graded on fluorescein angiography (minimally damaged/ disrupted/disorganized) were correlated to FAZ area and SCP/DCP density on OCTA (P < 0.01). By univariate analysis, worse VA was associated to macular detachment at presentation (P ¼ 0.024), total macular irradiation (P ¼ 0.0008), higher central macular thickness (CMT) (P ¼ 0.019), higher absolute CMT variation (P < 0.0001), cystoid edema (P ¼ 0.030), ellipsoid zone disruption (P ¼ 0.002), larger FAZ (P < 0.0001), lower SCP (P ¼ 0.001) and DCP capillary density (P < 0.0001), and lower SCP (P ¼ 0.009) and DCP local fractal dimension (P < 0.0001). Two multivariate models with either capillary density or fractal dimension as covariate showed that younger age (P ¼ 0.014/0.017), ellipsoid zone disruption (P ¼ 0.034/0.019), larger FAZ (P ¼ 0.0006/0.002), and lower DCP density (P ¼ 0.008) or DCP fractal dimension (P ¼ 0.012), respectively, were associated with worse VA.CONCLUSIONS. VA of eyes with radiation maculopathy is influenced by structural and microvascular factors identified with OCTA, including FAZ area and DCP integrity.

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Section: Discussionmentioning

confidence: 93%

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

Matet

Daruich

Zografos

2017

Invest. Ophthalmol. Vis. Sci.

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“…5,23 Optical coherence tomography A has already proved successful at qualitatively imaging the microvascular changes in diabetic retinopathy, retinal venous or arterial occlusion, choroidal neovascularization, and glaucoma. 13,14,[24][25][26][27] A novel software program recently released by the AngioVue system enables the quantitative evaluation of such microvascular changes.…”

Section: Resultsmentioning

confidence: 99%

“…10,11 Optical coherence tomography A has previously been used to describe the retinal vasculature in both normal eyes and various retinal vascular pathologies such as macular telangiectasia type 2, retinal vein occlusion, and diabetes. [12][13][14][15] The AngioVue (Optovue, Inc., Fremont, CA, USA) is one of the currently commercially available OCT-A machines that allows a four-section division of the retina-choroid complex: superficial capillary plexus (SCP), DCP, outer retinal layers, and choriocapillaris. A new software update recently released by the AngioVue system allows quantification of the VD around the macula.…”

mentioning

confidence: 99%

Normative Data for Vascular Density in Superficial and Deep Capillary Plexuses of Healthy Adults Assessed by Optical Coherence Tomography Angiography

Coscas

Sellam

Glacet–Bernard

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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301

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“…It has been reported that nonperfusion, microaneurysms, and enlargement of the nonperfusion area occur more frequently in the DCP compared with the SCP. 37,38 The DCP seems to be particularly important for visual acuity after anti-VEGF therapy. Our results are consistent with previous studies that addressed the favorable effects of retinal perfusion in the DCP on visual acuity in patients with RVO.…”

Section: Discussionmentioning

confidence: 99%

Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion

Winegarner

Wakabayashi

Fukushima

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate the changes in the retinal microvasculature during the course of anti-VEGF therapy in eyes with macular edema due to retinal vein occlusion (RVO) and their association with visual outcomes.METHODS. The vessel density (VD) and foveal avascular zone (FAZ) area in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were quantitatively measured by optical coherence tomography angiography (OCTA) in 48 consecutive eyes with RVO before and 1, 3, 6, 9, and 12 months after anti-VEGF therapy. Anti-VEGF therapy was performed either with ranibizumab or aflibercept following a pro re nata (PRN) regimen. The correlation between post-treatment best-corrected visual acuity (BCVA) and changes in the retinal microvasculature evaluated by OCTA were assessed.RESULTS. The BCVA improved significantly at 12 months (P < 0.001). Better BCVA at 12 months was significantly associated with a better VD in the SCP and DCP both at baseline (R 2 ¼ 0.524, P < 0.001 and R 2 ¼ 0.457, P < 0.001, respectively) and at 12 months (R 2 ¼ 0.521, P < 0.001 and R 2 ¼ 0.662, P < 0.001, respectively). Overall, both VD and FAZ did not change significantly during the 12 months. However, the progression of nonperfusion was observed in the SCP in 6 (13%) eyes and in the DCP in 10 (21%) eyes. The number of macular edema recurrence was significantly associated with a decrease in the VD (P ¼ 0.006 [SCP] and P < 0.001 [DCP]) and less visual gain (P ¼ 0.02) after treatment.CONCLUSIONS. Anti-VEGF therapy maintains retinal perfusion in most patients with RVO. Preserving retinal perfusion is crucial for better visual outcomes.

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Optical Coherence Tomography Angiography in Retinal Vein Occlusion: Evaluation of Superficial and Deep Capillary Plexa

Cited by 280 publications

References 33 publications

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

Normative Data for Vascular Density in Superficial and Deep Capillary Plexuses of Healthy Adults Assessed by Optical Coherence Tomography Angiography

Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion

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