Optical coherence tomography angiography in quiescent choroidal neovascularization associated with choroidal nevus: 5 years follow-up

Cennamo, Gilda; Montorio, Daniela; Fossataro, Federica; Clemente, Lidia; Carandente, Raffaella; Tranfa, Fausto

doi:10.1177/1120672120934390

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…There are only a few series of nevus-related CNV published in the literature [10,[12][13][14][15]18]. Like in our study, the majority of the nevi with accompanying CNV in all groups described by other authors were pigmented, with its incidence ranging from 67% to 91% [10,12,13].…”

Section: Discussionsupporting

confidence: 80%

Choroidal neovascularization related to melanocytic naevus – a single centre study

Zwolińska

Rospond-Kubiak

2022

Ophthatherapy

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Purpose: To assess the angiographic and optical coherence tomography angiography (OCTA) features as well as the natural course of the choroidal neovascularization (CNV) associated with choroidal naevi. Setting/venue: Ocular Oncology Service, Department of Ophthalmology, Poznan University of Medical Sciences. Material and methods: Retrospective chart analysis of the patients who presented to the Ocular Oncology Service in Poznan, Poland between 2011–2021 with the diagnosis of suspicious choroidal naevus. In all patients full ophthalmic examination and multimodal imaging, including fundus photography, autofluorescence, B-ultrasound, optical coherence tomography (OCT), OCT angiography (OCTA) and fluorescein angiography (FAF), were performed. Results: There were 9 lesions in 9 patients, 9 women aged 14–79 years (mean age: 58.2 years). All the lesions were located in the posterior pole and most of them were pigmented (88.9%). CNVs associated with choroidal naevi were type I in 66.7% and type II in 33.3% of cases. 5 patients required treatment: anti-VEGF injection (alone or with transpupillary thermotherapy) was administered. The median follow-up was 24 months (range: 2–145). In two of all treated patients (40%), we observed BCVA gain (2–4 lines), in one patient (20%) it remained stable and in two (40%) it deteriorated. The final visual acuity was below 0.1 only in 1 patient. During the period of observation none of the lesions progressed to uveal melanoma. Conclusions: CNV associated with choroidal naevus could be the reason for subretinal fluid (SRF) leakage and visual loss. The response to anti-VEGF treatment is satisfactory in the majority of patients. Choroidal naevi with accompanying CNV have none or very low malignant transformation potential.

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Section: Discussionsupporting

confidence: 80%

Choroidal neovascularization related to melanocytic naevus – a single centre study

Zwolińska

Rospond-Kubiak

2022

Ophthatherapy

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“…2 The possibility that choroidal nevus could complicate in CNV, whether type 1, type 2 or polypoid, active or quiescent, has already been reported in the scientific literature, as well as various therapeutic strategies. [3][4][5] Spectral domain-optical coherence tomography (SD-OCT) represents a useful tool to detect and confirm the CNV associated with choroidal nevus. In addition, OCT Angiography (OCT-A) can be helpful for analyzing and monitoring qualitative and quantitative vascular features of the CNV associated with choroidal nevus before and after treatments.…”

Section: Introductionmentioning

confidence: 99%

Choriocapillary vascular density changes in choroidal neovascularization associated with choroidal nevus after anti-VEGF injections

D’Andrea

Fossataro

Cennamo

2020

European Journal of Ophthalmology

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Purpose: To evaluate choriocapillary vascular density changes in choroidal neovascularization (CNV) type 2 associated with choroidal nevus using optical coherence tomography angiography (OCT-A) before and after anti-VEGF treatment. Methods: Observational case report. Results: A 25-year-old woman, was referred to Eye Clinic and presented a decreased visual acuity in right eye. Fundus examination showed a pigmented lesion located in macular region associated with subretinal hemorrhages adjacent to the mass in right eye. The diagnosis of choroidal nevus-associated with CNV was made and confirmed by spectral domain (SD)-OCT, OCT-A, and ultrasound examination. Two monthly ranibizumab intravitreal injections (IVT) were performed and a regression of the activity of neovascular lesion was noted. OCT-A showed a reduction of choriocapillaris vessel density (VD) before the treatment and an increase of VD after IVT injections. Conclusion: OCT-A could be a non-invasive and diagnostic tool to evaluate choriocapillaris vascular changes after IVT injections in CNV associated with choroidal nevus.

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91-month follow-up of solitary punctate chorioretinitis in a Chinese patient

Liu,

Lan

et al. 2024

BMC Ophthalmol

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Background Solitary Punctate Chorioretinitis (SPC) is a recently identified form of punctate inner choroidopathy (PIC) characterized by a single lesion in the fovea of the macula. Previous studies with a maximum follow-up of 48 months were insufficient. Our review uncovered a case sustained for 91 months. Case presentation A 28-year-old young woman experienced with sudden visual loss in her right eye. Comprehensive examinations, including assessment of best-corrected visual acuity (BCVA), slit-lamp biomicroscopy, noncontact tonometry, fundus fluorescein angiography (FFA), fundus autofluorescence (FAF), optical coherence tomography angiography (OCTA), perimetry, and microperimetry, were conducted. Over 91 months, the lesion slightly enlarged, remained yellow-white and punctate, and stayed in the central macula of the posterior pole. OCT images depicted subsidence in the inner nuclear layer (INL), the outer plexiform layer (OPL), photoreceptor layer, and disruption of the external limiting membrane (ELM), ellipsoid zone, and retinal pigment epithelium (RPE)/Bruch’s membrane complex. Retinal herniation, focal choroidal excavation (FCE), and abnormal vessels in the choriocapillaris were noted. At the slab of the choriocapillaris, OCTA demonstrated that the lesion resembled a linear vascular structure, distinct from the structure of normal choriocapillaris. This confirmed the lesion as an abnormal vascular formation. FAF revealed a punctate hypo-autofluorescence lesion and abnormal hyper-autofluorescence near the optic disc and macula. FFA demonstrated a punctate hyper-fluorescent lesion inferotemporal to the fovea. The vascular structure remained stable without fluid exudation on OCT images, hence anti-vascular endothelial growth factor (anti-VEGF) treatment was not administered. Visual acuity improved from counting fingers to 0.07 in 52 days, reached 0.6 after 15 months, remained at 0.6 from 56 to 80 months, and returned to 0.8 after 91 months, although accompanied by local scotomas. The lesion pattern slightly enlarged without scarring. Conclusions Throughout long-term follow-up, we had long suspected the presence of choroidal neovascularization (CNV) and found the FCE in the last visit. Eventually, we concluded that SPC could potentially constitute a distinct subtype of PIC. The patient received no treatment, and vision recovered to 0.8. If CNV is suspected in SPC, anti-VEGF treatment may not be necessary without activity on OCT, but close monitoring is essential.

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Optical coherence tomography angiography in quiescent choroidal neovascularization associated with choroidal nevus: 5 years follow-up

Cited by 3 publications

References 7 publications

Choroidal neovascularization related to melanocytic naevus – a single centre study

Choroidal neovascularization related to melanocytic naevus – a single centre study

Choriocapillary vascular density changes in choroidal neovascularization associated with choroidal nevus after anti-VEGF injections

91-month follow-up of solitary punctate chorioretinitis in a Chinese patient

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