Optical coherence tomography angiography in adult-onset foveomacular vitelliform dystrophy

Querques, Giuseppe; Zambrowski, Olivia; Corvi, Federico; Mière, Alexandra; Semoun, Oudy; Srour, Mayer; Souied, Eric H.

doi:10.1136/bjophthalmol-2016-308370

Cited by 34 publications

(22 citation statements)

References 25 publications

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“…SS-OCTA can also be used to reliably identify subclinical Type 1 CNV in asymptomatic eyes with the clinical diagnosis of “dry AMD”, also known as non-exudative intermediate AMD (Roisman, Zhang et al 2016). In addition, OCTA has been a useful tool for identifying the presence or absence of choroidal neovascularization in some masquerade conditions, such as adult-onset foveomacular vitelliform dystrophy (Querques, Zambrowski et al 2016) and central serous chorioretinopathy (Bonini Filho, de Carlo et al 2015). For NVAMD, OCT has served as a way to indirectly assess the levels of vascular endothelial growth factor (VEGF) by detecting the absence or presence of exudation or macular fluid.…”

Section: Review Of Clinical Studies Utilizing Octamentioning

confidence: 99%

Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

Kashani

Chen

Gahm

et al. 2017

Progress in Retinal and Eye Research

749

561

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OCT has revolutionized the practice of ophthalmology over the past 10 to 20 years. Advances in OCT technology have allowed for the creation of novel OCT-based methods. OCT-Angiography (OCTA) is one such method that has rapidly gained clinical acceptance since it was approved by the FDA in late 2016. OCTA images are based on the variable backscattering of light from the vascular and neurosensory tissue in the retina. Since the intensity and phase of backscattered light from retinal tissue varies based on the intrinsic movement of the tissue (e.g. red blood cells are moving, but neurosensory tissue is static), OCTA images are essentially motion-contrast images. This motion-contrast imaging provides reliable, high resolution, and non-invasive images of the retinal vasculature in an efficient manner. In many cases, these images are approaching histology level resolution. This unprecedented resolution coupled with the simple, fast and non-invasive imaging platform have allowed a host of basic and clinical research applications. OCTA has been shown to demonstrate many important clinical findings including areas of macular telangiectasia, impaired perfusion, microaneurysms, capillary remodeling, some types of intraretinal fluid, and neovascularization among many others. More importantly, OCTA provides depth-resolved information that has never before been available. Correspondingly, OCTA has been used to evaluate a spectrum of retinal vascular diseases including diabetic retinopathy (DR), retinal venous occlusion (RVO), uveitis, retinal arterial occlusion, and age-related macular degeneration among others. In this review, we will discuss the methods used to create OCTA images, the practical applications of OCTA in light of invasive dye-imaging studies (e.g. fluorescein angiography) and review clinical studies demonstrating the utility of OCTA for research and clinical practice.

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Section: Review Of Clinical Studies Utilizing Octamentioning

confidence: 99%

Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

Kashani

Chen

Gahm

et al. 2017

Progress in Retinal and Eye Research

749

561

View full text Add to dashboard Cite

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“…OCT-A is able to detect flow movement by detecting erythrocyte motion thus overcoming the constraints of dyebased angiography. Given its high sensitivity, OCT-A may detect newly formed CNV that are not yet symptomatic and/or not well visualized in standard imaging [19,20,22,[24][25][26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography features of choroidal neovascularization secondary to angioid streaks

Chapron

Mimoun

Mière

et al. 2018

Eye

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Purpose To characterize the features of choroidal neovascularization (CNV) secondary to angioid streaks (AS) with optical coherence tomography angiography (OCT-A) and to assess its sensitivity in CNV detection in this particular context. Methods Consecutive patients, both with treatment-naïve and recurrent CNV associated with angioid streaks were prospectively analyzed. All patients underwent macular imaging by fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain (SD)-OCT, and OCT-A (AngioVue, Optovue, Optovue Inc., Freemont, CA, USA). OCT-A detection rate of CNV associated to AS was evaluated by two independent observers. We studied the association between OCT-A feature and either exudative or active status using Fisher exact test. Results A total of 32 eyes of 18 consecutive patients were included in the analysis. OCT-A was able to detect CNV associated with angioid streaks in 87.5 % (28/32) eyes. OCT-A phenotypes of CNV were classified into interlacing pattern in 9 eyes, pruned vascular tree pattern in 7 eyes, and combined pattern in 12 eyes (Interuser agreement: 0.871 ± 0.071). CNV were not detectable in 4/32 eyes. There was a statistically significant association between the presence in OCT-A of densely ramified networks with both previous treatment status in the last 6 months (p < 0.001) and with exudative signs on SD-OCT (p = 0.014). Conclusion OCT-A appears as a sensitive tool for detection of CNV secondary to AS. The interlacing pattern was significantly associated with active and exudative features.

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“…In addition, RPE irregularities could be detected including irregular thickened RPE layer, and solitary or multiple RPE detachment(s) (PED). The atrophic stage of the disease is marked by diffuse disruption of the outer retinal layers including the external limiting membrane (ELM), inner segment/outer segment (IS/OS) photoreceptor junction, and marked atrophy or even disappearance of RPE cell layer [30,31].…”

Section: Best's Disease (Vitelliform Macular Dystrophy)mentioning

confidence: 99%

“…This peculiar configuration could be due to overcrowding of vessels being displaced by the vitelliform lesion, or due to compensatory dilatation of the para-macular vascular bed secondary to vessel rarefaction in the macula, with consequent increased blood flow. Likewise, the choriocapillaris shows vascular rarefaction with multiple hypointense flow-void areas, which could be explained by vascular impairment due to degenerative changes induced by mechanical compression or due to masking effect by the accumulating vitelliform material [30][31][32][33][34][35].…”

Section: Best's Disease (Vitelliform Macular Dystrophy)mentioning

confidence: 99%

“…The most dreadful complication of Best's disease is CNV formation, which could develop in some cases secondary to compromised RPE/Bruch's complex [30,[32][33][34]. The advent of CNV on top of Best's disease could pose a diagnostic challenge due to overlapping fluorescein patterns of the vitelliform material and PEDs in Best's disease and the fibrovascular and neovascular components of CNV.…”

Section: Choroidal Neovascularization Secondary To Best's Disease: a mentioning

confidence: 99%

See 1 more Smart Citation

Novel Insight into Morphological Features and Vascular Profile of Selected Macular Dystrophies Using Swept-Source Optical Coherence Tomography and Optical Coherence Tomography Angiography

Moussa¹,

Leila²

2018

OCT - Applications in Ophthalmology

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Our perception of macular dystrophies has evolved overtime from collective grouping into hereditary disorders of unclear etiology and no effective treatment to avid search for the underlying pathogenic mechanism that would provide base for future therapy. A causal conjunction between abnormalities in the photoreceptors layer and the RPE-Bruch's membrane complex and abnormal profile of the retinal vascular plexuses and the choriocapillaris-stands out as a plausible theory of pathogenesis. The recently introduced swept-source optical coherence tomography (SS-OCT) technology incorporates long-wavelength (1050-nm) scanning light, less susceptibility to sensitivity roll-off, and ultrahigh-speed image acquisition. These features enabled in vivo noninvasive visualization of different strata of the outer retina and the choriocapillaris with unprecedented finesse. Furthermore, the SS-OCT technology incorporated a blood flow detection algorithm; OCTARA that in tandem with the deeper penetration and superior axial resolution of SS-OCT enabled detailed assessment of the retinal capillary plexuses and the choriocapillaris in terms of structure and density. This novel technology could help explore yet undiscovered frontiers in the pathophysiology of macular dystrophies and guide future therapeutic approaches. This chapter includes a review of literature along with the authors' experience in imaging selected macular dystrophies using SS-OCT and SS-OCT angiography (SS-OCTA).

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Optical coherence tomography angiography in adult-onset foveomacular vitelliform dystrophy

Cited by 34 publications

References 25 publications

Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

Optical coherence tomography angiography features of choroidal neovascularization secondary to angioid streaks

Novel Insight into Morphological Features and Vascular Profile of Selected Macular Dystrophies Using Swept-Source Optical Coherence Tomography and Optical Coherence Tomography Angiography

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