Optical coherence tomography angiography in juvenile open angle glaucoma: correlation between structure and perfusion

Abdelrahman, Ahmed; Eltanamly, Rasha M; Elsanabary, Zeinab; Hassan, Lameece Moustafa

doi:10.1007/s10792-020-01643-7

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…In addition, a strong positive correlation has been found between the RNFL structural damage and peripapillary and ONH vascular density in juvenile open-angle glaucoma patients [22].…”

Section: Discussionmentioning

confidence: 90%

Peripapillary Vascular Density in Childhood Glaucoma: A Pilot Comparative Study with Age and Sex Matched Healthy Subjects

Xydaki,

Arribas-Pardo,

Burgos-Blasco

et al. 2023

JCM

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Purpose: The aim of this study concerns the evaluation of peripapillary vessel indices in childhood glaucoma (CG) and healthy subjects. Material and Methods: In this prospective, unicenter, observational cross-sectional study, patients with CG and age and sex-matched healthy subjects were included. We compared retinal nerve fiber layer (RNFL) measurements in optical coherence tomography (OCT), peripapillary vessel density (PVD), and the flux index (FI) of the superficial vascular plexus from OCT angiography (OCT-A) between CG patients and control groups. Results: We included 39 patients (68 eyes) with CG and 50 (95 eyes) healthy subjects. The peripapillary RNFL thickness, vessel density, and flux index were significantly lower in the CG group than in the control group. The mean PVD of CG patients was 0.52 ± 0.043%, compared with 0.55 ± 0.014%, p < 0.0001 in healthy subjects. The mean FI was 0.32 ± 0.054 versus 0.37 ± 0.028, p < 0.0001, in CG patients and healthy subjects, respectively. PVD and FI in the superior, inferior, and temporal sectors were significantly lower in CG. The peripapillary RNFL thickness showed a higher area under the ROC curve (AUROC) for discriminating healthy and CG eyes and was significantly different than the PVD (0.797, 95%CI 0.726–0.869; p < 0.0001 vs. 0.664, 95%CI 0.574–0.752; p 0.00037), p 0.012.Conclusions: PVD and FI show lower values in CG and correlate with RNFL thickness measurement but have lower diagnostic ability than RNFL thickness measurement. Our results reveal possible differences in the pathogenesis of microvascular compromise in childhood glaucoma patients.

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“…In addition, a strong positive correlation has been found between the RNFL structural damage and peripapillary and ONH vascular density in juvenile open-angle glaucoma patients [22].…”

Section: Discussionmentioning

confidence: 90%

Peripapillary Vascular Density in Childhood Glaucoma: A Pilot Comparative Study with Age and Sex Matched Healthy Subjects

Xydaki,

Arribas-Pardo,

Burgos-Blasco

et al. 2023

JCM

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“…Glaucoma occurring before the age of 40 is known as juvenile open-angle glaucoma, which tends to have more severe symptoms compared with adultonset primary open-angle glaucoma that occurs after the age of 40 [25,26]. Both types can lead to significant vascular damage in the optic nerve [27]. Therefore, it is possible that glaucoma associated with genetic defects and accompanied by vascular damage may result in the development of peripheral artery occlusive disease (PAOD) at a younger age.…”

Section: Discussionmentioning

confidence: 99%

Association of Glaucoma with the Risk of Peripheral Arterial Occlusive Disease: A Retrospective Population-Based Cohort Study

Yeh

Chung

Chang

et al. 2023

JCM

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This study aimed to investigate the potential association between glaucoma and peripheral arterial occlusive disease. The study recruited patients, including 101,309 with glaucoma and 1,860,528 without a glaucoma diagnosis, from a population of 2 million patients in the Longitudinal Health Insurance Database. Propensity score matching was performed between the two groups, matching for age, sex, and comorbidities. In total, 95,575 patients with glaucoma and 95,575 patients without glaucoma were analyzed for their risk of developing peripheral arterial occlusive disease. The analysis of the data revealed that the glaucoma group had a higher incidence density (ID = 4.13) of peripheral arterial occlusive disease than the non-glaucoma group (ID = 3.42). The relative risk for the glaucoma group was 1.21 (95% C.I. = 1.15–1.28). Cox proportional hazard model analysis indicated that the glaucoma group had a higher risk of developing peripheral arterial occlusive disease (HR = 1.18; 95% C.I. = 1.12–1.25). The subgroup analysis of the risk of PAOD showed that the glaucoma group had a higher risk of developing peripheral arterial occlusive disease in the age group of 20 to 39 (p for interaction = 0.002). In conclusion, patients with glaucoma were associated with a higher risk of subsequent peripheral arterial occlusive disease compared with those without a diagnosis of glaucoma.

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“…The structural damage to the optic nerve head and thinning of the retinal nerve fiber layer (RNFL) seen in JOAG has previously been studied. However, Abdelrahman et al [9 ▪ ] has recently investigated the association of vascular perfusion and structural damage in patients with JOAG by conducting a cross sectional study using optical coherence tomography angiography (OCT-A) [9 ▪ ]. Vascular perfusion was correlated with RNFL thinning in 25 JOAG eyes.…”

Section: Pathophysiology Of Juvenile Open-angle Glaucomamentioning

confidence: 99%

Juvenile open angle glaucoma: current diagnosis and management

Ciociola¹,

Klifto

2021

Current Opinion in Ophthalmology

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Purpose of reviewThe aim of this article is to summarize up-to-date research on the diagnosis and management of juvenile open-angle glaucoma (JOAG). Recent findingsJOAG can be subclassified into four clinical phenotypes, and faster myopic shift is a risk factor for disease progression. Vessel density is associated with structural damage and worsening visual acuity in JOAG and can be monitored with optical coherence tomography angiography. Genetic studies have revealed molecular causes of JOAG including variants in CPAMD8, MYOC, and CYP1B1. Tube shunt surgeries as well as gonioscopy-assisted transluminal trabeculotomy have been shown to be successful in JOAG. SummaryAlthough genetic advances may improve future screening, intraocular pressure monitoring and fundoscopic exam remain the current mainstay of diagnosis. Medical treatment alone for JOAG is typically insufficient with patients requiring surgical management. Selective laser trabeculoplasty may delay or decrease the need for surgery. Trabeculectomy has traditionally been shown to be effective in JOAG, but tube shunt surgery and microinvasive glaucoma surgery are effective alternatives.

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Optical coherence tomography angiography in juvenile open angle glaucoma: correlation between structure and perfusion

Cited by 8 publications

References 25 publications

Peripapillary Vascular Density in Childhood Glaucoma: A Pilot Comparative Study with Age and Sex Matched Healthy Subjects

Peripapillary Vascular Density in Childhood Glaucoma: A Pilot Comparative Study with Age and Sex Matched Healthy Subjects

Association of Glaucoma with the Risk of Peripheral Arterial Occlusive Disease: A Retrospective Population-Based Cohort Study

Juvenile open angle glaucoma: current diagnosis and management

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