Optical coherence tomography angiography in diabetic retinopathy: an updated review

Sun, Zihan; Yang, Dawei; Tang, Zhangjun; Ng, Danny Siu-Chun; Cheung, Carol Y.

doi:10.1038/s41433-020-01233-y

Cited by 118 publications

(110 citation statements)

References 90 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…Our study confirmed that the FAZ area’s enlargement was associated with DR progression 3 , 7 , 22 and that the FAZ area was significantly larger in eyes with higher FAZ outline grades. 15 , 29 …”

Section: Discussionsupporting

confidence: 86%

“…We analyzed two FAZ parameters, outline and size. FAZ outline might be a better indicator of ischemia given the heterogeneity in the size of FAZ in healthy persons (as reviewed by Sun et al 7 ). Johannesen et al postulated to determine FAZ area as a part of the diagnostic process but emphasized that this parameter might be unsuitable if used alone.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Foveal Avascular Zone Does Not Correspond to Choroidal Characteristics in Patients with Diabetic Retinopathy: A Single-Center Cross-Sectional Analysis

Sidorczuk¹,

Pieklarz²,

Konopińska³

et al. 2021

DMSO

View full text Add to dashboard Cite

Purpose The aim of the study was to compare two non-overlapping blood supply systems of the retina to obtain a better insight into the relation between diabetic macular retinopathy and choroidopathy. Specifically, the study focused on the relationships between (1) retinal vascular changes around the fovea in fluorescein angiography (FA) and (2) choroidal thickness, volume and other parameters assessed by optical coherence tomography (OCT). Patients and Methods The retrospective cross-sectional single-center study included 210 eyes from 152 patients with diabetic retinopathy (mean age 60.7±12.4 years, 49.3% of women; foveal avascular zone [FAZ] outline: 44.3% grade ≤2, 55.7% grade ≥3). The outline of FAZ, a measure of capillary loss due to ischemic processes, was analyzed on FA according to the Early Treatment Diabetic Retinopathy Study Research Group (ETDRS) standards. The eyes were stratified according to the FAZ outline and size and the presence of clinically significant diabetic macular edema (CSME). Then, resultant groups were compared in terms of the spectral domain OCT parameters: choroidal thickness and volume (within ETDRS subfields), luminal, stromal and total choroidal areas and choroidal vascularity index (based on the foveal scan). Statistical analysis was based on univariate models with the choroidal parameters as independent variables, and age, sex, panretinal photocoagulation, the severity of diabetic retinopathy and CSME as covariates. Results No significant relationships were found between the FAZ outline and area and choroidal characteristics of patients with diabetic retinopathy. In patients without CSME, no correlation was observed between the FAZ area and choroidal characteristics. In patients with CSME, no correlation was found between the FAZ area and choroidal characteristics other than the choroidal vascularity index. Conclusion In patients with diabetic retinopathy, damage to the macular retinal vasculature (FAZ) does not seem to be associated with changes in the choroidal vasculature, and these two processes appear to occur independently.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Foveal Avascular Zone Does Not Correspond to Choroidal Characteristics in Patients with Diabetic Retinopathy: A Single-Center Cross-Sectional Analysis

Sidorczuk¹,

Pieklarz²,

Konopińska³

et al. 2021

DMSO

View full text Add to dashboard Cite

show abstract

“…Comprehensively, a combined OCT/SLO system comprises AO-SLO for imaging physiological events of retinal components such as blood flow, microglia cells, capillaries, GFP expression of cone photoreceptor cells and its three-dimensional localization by combining with the widefield OCT/pv-OCT and SLO records. Similarly, Optical coherence tomography angiography (OCTA) is an innovative utilization of OCT for the visualization of retinal layers without use of dyes 115 . It has several features such as increased acquisition speed and image information over the dye based angiographic system 116 .…”

Section: Imaging Biomarkersmentioning

confidence: 99%

Non-invasive multimodal imaging of Diabetic Retinopathy: A survey on treatment methods and Nanotheranostics

Sadasivam¹,

Gopinath²,

Shakya³

et al. 2021

Nanotheranostics

View full text Add to dashboard Cite

Diabetes Retinopathy (DR) is one of the most prominent microvascular complications of diabetes. It is one of the pre-eminent causes for vision impairment followed by blindness among the working-age population worldwide. The de facto cause for DR remains challenging, despite several efforts made to unveil the mechanism underlying the pathology of DR. There is quite less availability of the low cost pre-emptive theranostic imaging tools in terms of in-depth resolution, due to the multiple factors involved in the etiology of DR. This review work comprehensively explores the various reports and research works on all perspectives of diabetic retinopathy (DR), and its mechanism. It also discusses various advanced non-destructive imaging modalities, current, and future treatment approaches. Further, the application of various nanoparticle-based drug delivery strategies used for the treatment of DR are also discussed. In a nutshell, the present review work bolsters the pursuit of the development of an advanced non-invasive optical imaging modal with a nano-theranostic approach for the future diagnosis and treatment of DR and its associated ocular complications.

show abstract

“…Diabetes mellitus affects negatively both vascular systems mentioned above [ 2 , 3 ]. Analogically to retinal abnormalities, diabetes may result in choroidal changes, such as microaneurysms, dilatation, and obstruction of the vessels, vascular remodelling with increased vascular tortuosity, vascular dropout, focal vascular non-perfusion, and choroidal vascularisation [ 4 , 5 , 6 ]. The histological findings are consistent with abnormalities observed on optical coherence tomography (OCT) [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of Choroidal Parameters in Patients with Various Types of Diabetic Macular Oedema: A Single-Centre Cross-Sectional Analysis

Dmuchowska

Sidorczuk

Pieklarz

et al. 2021

Biology

View full text Add to dashboard Cite

Diabetic macular oedema (DME) is an outcome of multiple, complex and not fully understood mechanisms. The aim of this study was to define the role of choroidopathy in the pathogenesis of various DME types. The retrospective cross-sectional single-centre study included 140 eyes from 105 patients with DME and 76 eyes from 52 non-diabetic controls. The eyes were stratified according to the type of DME: cystoid, diffuse, and with subretinal fluid. Optical coherence tomography-based choroidal parameters: thickness, volume, choroidal vascularity index (CVI), luminal area (LA), stromal area (SA), and total choroidal area (TCA) were compared. Eyes with DME, regardless of the type thereof, had lower choroidal thickness, volume, and CVI values than the controls. Further, the eyes with some specific DME types differed significantly from the controls in terms of LA and SA. While the eyes with various DME types did not differ significantly in terms of their choroidal thickness, volume and CVI, some between-group differences were found in LA, SA and TCA. Diabetic choroidopathy seems to play a role in the development of DME but is less likely involved in the pathogenesis of specific types thereof.

show abstract

Optical coherence tomography angiography in diabetic retinopathy: an updated review

Cited by 118 publications

References 90 publications

Foveal Avascular Zone Does Not Correspond to Choroidal Characteristics in Patients with Diabetic Retinopathy: A Single-Center Cross-Sectional Analysis

Foveal Avascular Zone Does Not Correspond to Choroidal Characteristics in Patients with Diabetic Retinopathy: A Single-Center Cross-Sectional Analysis

Non-invasive multimodal imaging of Diabetic Retinopathy: A survey on treatment methods and Nanotheranostics

Quantitative Assessment of Choroidal Parameters in Patients with Various Types of Diabetic Macular Oedema: A Single-Centre Cross-Sectional Analysis

Contact Info

Product

Resources

About