Optical coherence tomography angiography in primary eye care

Abstract

Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality for assessing the vasculature within ocular structures including the retina, macula, choroid and optic nerve. OCT-A has a wide range of clinical applications in various optometric conditions which have been independently reported in the literature. This paper aims to present a review of the current literature on the clinical application of OCT-A in optometric practice as well as to analyse and evaluate the quality of the available evidence. This review included 78 articles from a literature search conducted on 26 May 2019 across the following databases: Cochrane Library of Systematic Reviews, Medline, Scopus and Web of Science. Primary ocular pathologies discussed in this review include glaucoma, diabetic retinopathy, age-related macular degeneration, myopia, acquired and congenital macular dystrophies, epiretinal membrane, retinal vein occlusion, retinitis pigmentosa, choroidal melanoma, uveitis, central serous chorioretinopathy, amblyopia and optic neuropathies. Primary outcome variables included vessel density, foveal avascular zone area and diameter, flow velocity and flow index. This review aims to evaluate the evidence available for OCT-A applications in diagnosis and prognosis of ocular conditions in an optometric setting.

Correlative study on retinal microvascular changes and sex hormones in male patients with central serous chorioretinopathy

“…OCTA is a new technique used to examine fundus lesions over recent years. This method can clearly demonstrate the morphological characteristics of superficial choroidal vessels and can quantitatively detect retinal blood flow signals [19,20]. In the present study, OCTA revealed that the SCT of the affected eyes of CSC patients was significantly thicker than that of the healthy eyes.…”

Optical coherence tomography angiography (OCT-A) in retinitis pigmentosa and macular dystrophy patients: a retrospective study

“…For both RP and MD, the knowledge about alterations of small retinal vessels in the macular area is limited. Multiple degenerative retinal disorders present changes in the avascular zone and reduction in vessel density (VD) or perfusion when examined with OCT-A [9].…”

Mingmu Xiaoyao granules regulate the PI3K/Akt/mTOR signaling pathway to reduce anxiety and depression and reverse retinal abnormalities in rats

“…This 10-layer structure is shown in Figure 5A . OCTA is a non-invasive mode of retinal angiography that can not only analyze the structure of the retina but also shows the network of retinal blood vessels in vivo ( Arya et al, 2018 ; Spaide et al, 2018 ; Coffey et al, 2021 ). The inner retina is supplied with oxygen and nutrients by the central retinal artery and the outer retina by the choroidal vessels ( Kur et al, 2012 ).…”