Optical coherence tomography angiography in glaucoma

Bojikian, Karine D.; Chen, Philip; Wen, Joanne C

doi:10.1097/icu.0000000000000554

Cited by 43 publications

(37 citation statements)

References 42 publications

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“…Some authors even regard normal tension glaucoma as an ocular manifestation of a systemic vascular dysfunction, as reflected in the so called Flammer syndrome [32,33]. Other research groups found retinal vascular abnormalities in normal-tension and high-tension glaucoma patients, which include narrowing of retinal blood vessels, optic disc hemorrhage, and reduction of blood vessel density [12,34,35]. However, so far none of them has shown that increased IOP induces vascular dysfunction itself possibly triggering further IOP-independent RGC loss by means of vessel dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles

Gericke

Mann

Zadeh

et al. 2019

Oxidative Medicine and Cellular Longevity

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Objective. Glaucoma is a leading cause of severe visual impairment and blindness. Although high intraocular pressure (IOP) is an established risk factor for the disease, the role of abnormal ocular vessel function in the pathophysiology of glaucoma gains more and more attention. We tested the hypothesis that elevated intraocular pressure (IOP) causes vascular dysfunction in the retina. Methods. High IOP was induced in one group of mice by unilateral cauterization of three episcleral veins. The other group received sham surgery only. Two weeks later, retinal vascular preparations were studied by video microscopy in vitro. Reactive oxygen species (ROS) levels and expression of hypoxia markers and of prooxidant and antioxidant redox genes as well as of inflammatory cytokines were determined. Results. Strikingly, responses of retinal arterioles to stepwise elevation of perfusion pressure were impaired in the high-IOP group. Moreover, vasodilation responses to the endothelium-dependent vasodilator, acetylcholine, were markedly reduced in mice with elevated IOP, while no differences were seen in response to the endothelium-independent nitric oxide donor, sodium nitroprusside. Remarkably, ROS levels were increased in the retinal ganglion cell layer including blood vessels. Expression of the NADPH oxidase isoform, NOX2, and of the inflammatory cytokine, TNF-α, was increased at the mRNA level in retinal explants. Expression of NOX2, but not of the hypoxic markers, HIF-1α and VEGF-A, was increased in the retinal ganglion cell layer and in retinal blood vessels at the protein level. Conclusion. Our data provide first-time evidence that IOP elevation impairs autoregulation and induces endothelial dysfunction in mouse retinal arterioles. Oxidative stress and inflammation, but not hypoxia, appear to be involved in this process.

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Section: Discussionmentioning

confidence: 99%

Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles

Gericke

Mann

Zadeh

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…OCTA parameters of all areas have good intravisit repeatability in subjects with glaucoma [83,91]. As OCTA introduced only recently, at the time of this writing, there is no information about the ability of this device to track changes longitudinally.…”

Section: Optical Coherence Tomography Angiographymentioning

confidence: 99%

“…Detection of glaucomatous damage in highly myopic eyes is challenging due to myopiainduced RNFL thinning [91]. However, peripapillary perfused capillary density (vessel density with large vessels removed) showed a progressive reduction in mean capillary density from healthy eyes to myopic eyes without glaucoma, glaucomatous eyes without myopia to glaucomatous eyes with myopia [93].…”

Section: Optical Coherence Tomography Angiographymentioning

confidence: 99%

Comprehensive Glaucoma Imaging

Glidai¹,

Kahook²,

Noecker³

et al. 2020

Albert and Jakobiec's Principles and Practice of Ophthalmology

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Advancements in ocular imaging over the past four decades have revolutionized glaucoma practice worldwide. As glaucomatous vision loss cannot be restored, early diagnosis, proper management, and timely intervention are essential to slow disease progression. The emergence of advanced computerized imaging modalities has shifted glaucoma assessment from being largely subjective to mostly objective. These modalities can document and accurately quantify the optic nerve head and the macula regions, which are affected by the disease. With various ocular imaging devices

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“…The optimum method to evaluate blood flow in the optic disc region in glaucomatous eyes is 4.5 mm × 4.5 mm scanning. The analysis may cover: 1) whole en face image, 2) the papillary region defined as a circle with a diameter of 3 mm, with the center in the middle of the optic disc, 3) the peripapillary region defined as a ring with an inner diameter of 500 μm and an outer diameter of 700 μm, and 4) the optic disc only (Figure 1) [32].…”

Section: Optical Coherent Tomography Angiographymentioning

confidence: 99%

Evaluation of ocular blood flow in glaucoma – possibilities and barriers

Wierzbowska¹

2020

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Optical coherence tomography angiography in glaucoma

Cited by 43 publications

References 42 publications

Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles

Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles

Comprehensive Glaucoma Imaging

Evaluation of ocular blood flow in glaucoma – possibilities and barriers

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