Optical coherence tomography angiography findings in systemic lupus erythematosus patients with no ocular disease

Pichi, Francesco; Woodstock, Elizabeth; Hay, Steven; Neri, Piergiorgio

doi:10.1007/s10792-020-01388-3

Cited by 39 publications

(39 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vascular status of the retina has been investigated by OCTA in other inflammatory systemic pathologies with no evidence of ocular involvement. Pichi et al (2020) reported lower values of VD in the superficial capillary plexuses in systemic lupus erythematosus patients. Blood flow in retinal vascular plexuses is dysregulated in the course of inflammation and OCTA has been identified as a sensitive tool for evaluating the vessel modification related to inflammation.…”

Section: Discussionmentioning

confidence: 91%

See 1 more Smart Citation

Retinal Vascular Assessment in Psoriasis: A Multicenter Study

et al. 2021

View full text Add to dashboard Cite

PurposeTo investigate the vascular status of the macula in psoriasis patients without history of ocular inflammation by Optical Coherence Tomography Angiography (OCTA).MethodsThis prospective cross-sectional multicenter study included 55 psoriasis patients and 55 control healthy subjects. A complete eye examination and 6 mm × 6 mm OCTA imaging were performed. Retinal vascular status was evaluated by analyzing vascular density (VD) of superficial vascular plexus (superficial wVD) and deep vascular plexuses (deep wVD) in a 6 mm × 6 mm area and in foveal (superficial fVD and deep fVD) and parafoveal sectors (superficial pVD and deep pVD). In addition, foveal thickness (FT) and foveal avascular zone (FAZ) and clinical variables, including best corrected visual acuity (BCVA), intraocular pressure and refractive condition, were collected.ResultsBCVA, intraocular pressure and refractive condition were comparable between cases and controls. OCTA imaging showed that superficial wVD and superficial pVD were lower in the psoriasis group in comparison with controls (p = 0.009 and p = 0.01, respectively). Similarly, deep wVD and pVD were lower in the psoriasis group in comparison with control subjects (p = 0.03 and p = 0.01, respectively). In a sub-analysis of 47 patients affected by psoriasis without psoriatic arthritis, lower values of wVD and pVD in both superficial and deep capillary plexuses were registered.ConclusionOCTA is a useful tool which provides data on vascular status of the retina in psoriasis with no ocular involvement. VD data may suggest that vascular changes may occur earlier than clinical onset of posterior inflammation.

show abstract

Section: Discussionmentioning

confidence: 91%

“…In several systemic inflammatory diseases with no clinical signs of ocular involvement, a vascular impairment of the retina has been shown (Dai et al, 2020;Pichi et al, 2020). Vascular assessment of the retina has been significantly improved by optical coherence tomography angiography (OCTA) (Spaide et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Retinal Vascular Assessment in Psoriasis: A Multicenter Study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In other diseases, these features of iris vessels have been con rmed. Francesco et al [25] found that in patients with systemic lupus erythematosus the iris blood ow of patients was higher than that in healthy controls when there were no clinical changes in the fundus. In addition, Kivlin [26] thought that iris vasodilation was a sign of Retinopathy of Prematures (common ischemic retinopathy in childhood).…”

Section: Discussionmentioning

confidence: 99%

Quantitative Analysis and Clinical Application of Iris Circulation in Ischemic Retinal Disease

Jia

Xue

Tong

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: To evaluate quantitative changes of iris blood circulation in patients with ischemic risk.Methods: A clinical case series study. Patients with diabetic retinopathy (DR) and retinal vein occlusion (RVO) were included in this study. RVO affected eyes, RVO contralateral, and healthy control eyes were compared. We also compared eyes with proliferative diabetic retinopathy (PDR) and the contralateral eye without PDR (NPDR), patients with diabetes mellitus (DM) without DR (NDR), and healthy control eyes. The microvascular networks of the iris and retina were analyzed using optical coherence tomography angiography (OCTA). The analysis included vessel area density (VAD) and vessel skeleton density(VSD) of iris and retina.Results: In RVO group, the VAD and VSD of iris in the affected eye were higher than those in contralateral and healthy control, and the VAD and VSD of contralateral eyes were higher than those of healthy control. The retinal blood flow of RVO eye was less than the contralateral and healthy control eyes, but there were no difference between the contralateral eyes and healthy control eyes. The VAD and VSD of iris in PDR were larger than NPDR, and the NPDR were larger than NDR. There were no differences between NDR and healthy control eyes. Also, there were no difference among the four groups in retinal blood flow. Conclusions: Compared with the retina, iris blood circulation quantitative analysis data are more sensitive to ischemia and may be used as a new predictor of ischemic disease.Trial registration: The trial is registered with the clinical trial registration number nct03631108.

show abstract

“…In other diseases, these features of iris vessels have been confirmed. Francesco et al [ 25 ] found that in patients with systemic lupus erythematosus, the iris blood flow of patients was higher than that in healthy controls when there were no clinical changes in the fundus. In addition, Kivlin [ 26 ] thought that iris vasodilation was a sign of retinopathy of prematurity (common ischemic retinopathy in childhood).…”

Section: Discussionmentioning

confidence: 99%

Quantitative analysis and clinical application of iris circulation in ischemic retinal disease

et al. 2021

View full text Add to dashboard Cite

Background To evaluate quantitative changes in iris blood circulation in patients with ischemic risk. Methods This observational case-control study included 79 patients with diabetic retinopathy (DR) and retinal vein occlusion (RVO). The RVO group included 21 patients; the monocular proliferative diabetic retinopathy (PDR) group included 19 patients; the nondiabetic retinopathy (NDR) group included 18 patients; and the healthy control group included 21 healthy controls. In the RVO group, we analyzed RVO affected eyes, RVO contralateral eyes, and healthy control eyes. We also compared eyes with PDR and contralateral eyes without PDR, patients with diabetes mellitus (DM) without DR, and healthy control eyes. The microvascular networks of the iris and retina were analyzed using optical coherence tomography angiography. The analysis included vessel area density (VAD) and vessel skeleton density (VSD) of iris and retina. Results In the RVO group, the VAD and VSD of iris in the affected eye were higher than those in contralateral and healthy control eyes, and the VAD and VSD of contralateral eyes were higher than those of healthy control eyes. The retinal blood flow of the RVO eyes was less than that of the contralateral and healthy control eyes, but there were no difference between the contralateral eyes and healthy control eyes. The VAD and VSD of iris in PDR were larger than nonproliferative diabetic retinopathy (NPDR) and the NPDR were larger than NDR. There were no differences between NDR and healthy control eyes. Also, there were no differences among the four groups with respect to retinal blood flow. Conclusions Compared with the retina, iris blood circulation quantitative analysis data seem to be more sensitive to ischemia and may be used as a new predictor of ischemic disease, even if further research is needed to better understand the clinical value and importance of this analysis. Trial registration The trial is registered with the clinical trial registration number nct03631108.

show abstract

Optical coherence tomography angiography findings in systemic lupus erythematosus patients with no ocular disease

Cited by 39 publications

References 18 publications

Retinal Vascular Assessment in Psoriasis: A Multicenter Study

Retinal Vascular Assessment in Psoriasis: A Multicenter Study

Quantitative Analysis and Clinical Application of Iris Circulation in Ischemic Retinal Disease

Quantitative analysis and clinical application of iris circulation in ischemic retinal disease

Contact Info

Product

Resources

About