Optical Coherence Tomography Angiography Features of Intrachoroidal Peripapillary Cavitation

Mazzaferro, Andrea; Carnevali, Adriano; Zucchiatti, Ilaria; Querques, Lea; Bandello, Francesco; Querques, Giuseppe

doi:10.5301/ejo.5000901

Cited by 10 publications

(8 citation statements)

References 7 publications

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“…However, a further topographical sub-analysis revealed that the peripapillary zone was actually characterized by an increase of the signal voids, as compared with the CC distinct zones in myopic group (Table 3). In agreement with previous studies 25,26 , we hypothesized that this finding could be secondary to the expansion of the globe leading to a localized deformation of the peripapillary region with CC stretch. Thus, it is possible that the reduction of the choriocapillaris network as visualized by SS-OCTA could be a direct consequence of this mechanical deformation.…”

Section: Discussionsupporting

confidence: 91%

In Vivo Mapping of the Choriocapillaris in High myopia: a Widefield Swept Source Optical Coherence Tomography Angiography

Mastropasqua

Viggiano

Borrelli

et al. 2019

Sci Rep

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To report variation of choriocapillaris (CC) flow in widefield in high in myopic subjects compared with an age-matched normal control group using ultra widefield optical coherence tomography angiography (UW-OCTA). This is a Prospective, cross-sectional study. Thirty high myopia subjects and fifty healthy subjects were enrolled. Healthy and high myopia subjects were imaged with the SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). For each eye, five 12 × 12-mm OCTA volume scans were acquired. The en face CC images were then exported to imageJ and a semi-automated algorithm was used for subsequent quantitative analysis. The main outcome was a quantitative analysis of the CC. This analysis was performed in three different regions: (i) peripapillary, (ii) macular, and (iii) periphery. In addition, CC variables were further investigated in distinct fields within these three different regions. Thirty myopic eyes (32 subjects; myopic group) and fifty eyes (50 subjects; control group) without elevated myopia were included in the analysis. Mean ± SD age was 26.9 ± 2.9 years [median: 27 years; range: 20.0–40.0 years]. Mean ± SD axial length was 26.6 ± 0.6 mm [median: 26.2 mm; range: 26.1 to 28.0 mm]. Mean ± SD axial length was 26.6 ± 0.6 mm [median: 26.2 mm; range: 26.1 to 28.0 mm] in the myopic group and 23.9 ± 1.1 mm [median: 23.9 mm; range: 21.8 to 25.9 mm] in the control group. The total signal void area was significantly greater in myopic eyes compared with control group. The peripapillary region exhibited the greatest total signal void area (p < 0.0001 vs macular region, p < 0.0001 vs peripheral region). Within the macular region, the foveal area exhibited a greater total signal void area in comparison with both the parafoveal area (p < 0.0001) and the perifoveal area (p < 0.0001). In conclusion we report quantitative mapping of the choriocapillaris in myopic eyes compared with an age-matched normal control group. The CC perfusion appears to have a wide topographical variation.

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Section: Discussionsupporting

confidence: 91%

In Vivo Mapping of the Choriocapillaris in High myopia: a Widefield Swept Source Optical Coherence Tomography Angiography

Mastropasqua

Viggiano

Borrelli

et al. 2019

Sci Rep

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“…Mazzaferro et al using OCTA imaging demonstrated that PICC was characterized by the absence of choroidal and choriocapillary network. 11 In this study we analyzed the VD of RPC (whole papillary region and the four peripapillary sectors) in myopic eyes with PICC complicated by CNV, with PICC without CNV and in myopic eyes without PICC and CNV. We found that myopic eyes with PICC presented a statistically significant reduction in VD of whole papillary and peripapillary areas compared to myopic eyes without PICC.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography in myopic peripapillary intrachoroidal cavitation complicated by choroidal neovascularization

Comune

Montorio

Cennamo

2020

European Journal of Ophthalmology

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Purpose: To detect the vessel density (VD) of the radial peripapillary capillary (RPC) in eyes affected by pathological myopia with or without a peripapillary intrachoroidal cavitation (PICC) and in eyes with PICC complicated by choroidal neovascularization (CNV), using optical coherence tomography angiography (OCTA). Methods: We prospectively enrolled highly myopic patients from January 2016 to December 2019 at the Eye Clinic of the University of Naples “Federico II.” We divided included patients into three groups: group 1 including patients with PICC complicated by CNV; group 2 including patients with PICC without complications; group 3 including patients with high myopia without PICC and CNV. One-way analysis of variance (ANOVA) followed by Bonferroni post hoc analysis was used to evaluate differences in VD of radial peripapillary capillary (RPC) in papillary whole, peripapillary regions and its sectors among the three groups. Results: We enrolled 12 highly myopic eyes with PICC complicated by CNV, 21 highly myopic eyes with PICC without CNV and 23 highly myopic eyes without PICC. The myopic eyes with PICC revealed a statistically significant reduction in VD of the RPC comparing to the other groups ( p < 0.001), especially in eyes affected by myopic PICC complicated by CNV ( p < 0.001). These results were similar analyzing the VD in different sectors of the peripapillary region among the three groups ( p < 0.001). Conclusion: OCTA detects the changes in peripapillary vascular density of highly myopic eyes. We demonstrated that the RPC vasculature is significantly influenced by the presence of PICC, especially in myopic eyes developing a CNV.

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“…Indocyanine green angiography (ICGA) shows the area of peripapillary cavitation is hypofluorescent throughout the entire sequence. 12 , 21 Literature on OCT-angiography (OCT-A) use in pICC is limited. A case report by Mazzaferro et al on a 67-year-old female with pathologic myopia and pICC demonstrated a hyporeflective area corresponding to the cavitation on OCTA which may indicate a sluggish choriocapillaris vasculature or a complete absence of choroid.…”

Section: Intrachoroidal Cavitation (Icc)mentioning

confidence: 99%

Section: Intrachoroidal Cavitation (Icc)mentioning

confidence: 99%

“…A case report by Mazzaferro et al on a 67-year-old female with pathologic myopia and pICC demonstrated a hyporeflective area corresponding to the cavitation on OCTA which may indicate a sluggish choriocapillaris vasculature or a complete absence of choroid. 21 Peripapillary ICC is predominantly found in pathologic or high myopia but may occur in lower degrees of myopia and rarely in hyperopia. 11,16,17,19 Pathologic myopia is defined as a refractive error ≥-6.00 diopters and an axial length >26 mm.…”

Section: Intrachoroidal Cavitation (Icc) Peripapillary Intrachoroidal Cavitationmentioning

confidence: 99%

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<p>Choroidal Cavitary Disorders</p>

Nassar¹,

Tarbett²,

Browning³

2020

OPTH

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The structure and functions of the choroid have been long acknowledged but the pathophysiology behind various anomalies has been difficult to understand until the advent of optical coherence tomography (OCT). With OCT imaging, choroidal cavitations appear as optically empty spaces between the outer retinal and choroidal layers with attenuation or loss of outer retinal layers. Choroidal cavitations are found in the posterior pole and seen in conditions such as pathologic myopia, north carolina macular dystrophy (NCMD), focal choroidal excavation (FCE), and torpedo maculopathy (TM). To date, these disorders have not been linked. A commonality they all share is malformation of the RPE-photoreceptor-choroid complex. The following report describes the differences and similarities of choroidal cavitation amongst the different retinal disorders and emphasizes the importance of multimodal imaging in the detection and management of potential complications.

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Optical Coherence Tomography Angiography Features of Intrachoroidal Peripapillary Cavitation

Abstract: Optical coherence tomography angiography demonstrated the absence of choroidal and choriocapillary network.

Cited by 10 publications

References 7 publications

In Vivo Mapping of the Choriocapillaris in High myopia: a Widefield Swept Source Optical Coherence Tomography Angiography

In Vivo Mapping of the Choriocapillaris in High myopia: a Widefield Swept Source Optical Coherence Tomography Angiography

Optical coherence tomography angiography in myopic peripapillary intrachoroidal cavitation complicated by choroidal neovascularization

<p>Choroidal Cavitary Disorders</p>

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