Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy

Cao, Dan; Yang, Dawei; Huang, Zhongning; Zeng, Yunkao; Wang, Jun; Hu, Yunyan; Zhang, Liang

doi:10.1007/s00592-018-1115-1

Cited by 144 publications

(160 citation statements)

References 25 publications

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“…It had been well known that the reduction of vessel density is correlated to the severity of diabetic retinopathy . Although most of our patients did not have any diabetic retinopathy, prior OCTA studies had demonstrated that microvascular changes may occur before clinically detectable diabetic retinopathy …”

Section: Discussionmentioning

confidence: 77%

Early retinal microvascular abnormalities in patients with chronic kidney disease

Yeung

Sun

et al. 2019

Microcirculation

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ObjectiveTo evaluate early retinal microvascular abnormalities in patients with chronic kidney disease (CKD) via optical coherence tomography angiography.MethodsA cross‐sectional study. Two hundred patients with CKD stage ≧3 were enrolled in the CKD group, and 50 age‐matched healthy subjects were enrolled in the control group. Main outcome measures were the differences in parafoveal vessel densities in the superficial vascular plexus (SVP) and deep vascular plexus (DVP) between the CKD and control groups.ResultsThe mean ages were 62.7 ± 10.1 in the CKD group and 61.9 ± 9.7 (P = 0.622) in the control group. The CKD group had reduced parafoveal vessel densities in SVP (46.7 ± 4.3 vs 49.7 ± 2.9, P < 0.001) and DVP (50.1 ± 4.1 vs 52. 6 ± 2.9, P < 0.001) when compared to those of the control group. In multiple linear regression models, age, diabetes, estimated glomerular filtration rate, and use of anti‐hypertensive drugs were factors associated with vessel density in SVP, whereas age, diabetes, and smoking were factors associated with vessel density in DVP.ConclusionPatients with CKD had reduced vessel densities in parafoveal SVP and DVP, as compared to that of control subjects. Microvasculature in the different retinal layers may be affected by different systemic factors.

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Section: Discussionmentioning

confidence: 77%

Early retinal microvascular abnormalities in patients with chronic kidney disease

Yeung

Sun

et al. 2019

Microcirculation

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“…Traditionally, DR has been considered as a microvascular disease of the retina. Our previously published paper has pointed out that diabetic patients without DR had superficial capillary plexus, deep capillary plexus and choriocapillaris impairment in macular area . However, growing evidence suggested that neurodegenerative changes occurred in early diabetes.…”

Section: Discussionmentioning

confidence: 98%

“…Our previously published paper has pointed out that diabetic patients without DR had superficial capillary plexus, deep capillary plexus and choriocapillaris impairment in macular area. 23 However, growing evidence suggested that neurodegenerative changes occurred in early diabetes. For example, several studies have documented subtle changes in colour perception and contrast sensitivity in diabetic eyes in the absence of visible retinopathy.…”

Section: Discussionmentioning

confidence: 99%

Optic nerve head perfusion changes preceding peripapillary retinal nerve fibre layer thinning in preclinical diabetic retinopathy

Cao

Yang

et al. 2018

Clinical Exper Ophthalmology

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“…Patients with type 1 diabetes without DR had an increased FAZ area in the deep vascular layer compared to patients with type 2 diabetes without DR [6]. Some studies found a significantly decreased vessel density in both superficial and deep vascular layers in patients without DR [7, 9]; however, in three other reports, vessel density was significantly reduced only in the deep vascular layer [10-12]. Fractal dimension was also significantly reduced in both superficial and deep vascular layers of patients with type 2 diabetes without DR [13].…”

Section: Octa Parameters In the Superficial Deep And/or Intermediatmentioning

confidence: 99%

Implication of Deep-Vascular-Layer Alteration Detected by Optical Coherence Tomography Angiography for the Pathogenesis of Diabetic Retinopathy

Dimitrova¹,

Chihara²

2019

Ophthalmologica

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The aim of this narrative mini review is to analyze optical coherence tomography angiography (OCTA) parameters from reports that involved both superficial and deep vascular layers in patients with diabetes and to assess their relevance for the pathogenesis of diabetic retinopathy (DR). Papers published from January 2015 to August 2018 describing the use of OCTA in diabetes were identified and reviewed through a Medline/PubMed search. OCTA studies suggest that parameters are altered in patients with diabetes in all retinal vascular layers. From all included studies that evaluated both the superficial and the deep vascular layer, a number of studies suggested that the deep vascular layer was affected at an earlier stage of DR. OCTA parameter alterations were more prominent in the deep vascular layer than in the superficial vascular layer in patients with DR, and deep-vascular-layer alterations were most evident in patients with diabetic macular edema. Regarding that retinal venules originate from the deep vascular layer of the retina, alteration of OCTA parameters at the deep vascular layer in diabetic patients may imply a predominant affection of the venous side of the retinal vascular system in the pathogenesis of DR.

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Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy

Cited by 144 publications

References 25 publications

Early retinal microvascular abnormalities in patients with chronic kidney disease

Early retinal microvascular abnormalities in patients with chronic kidney disease

Optic nerve head perfusion changes preceding peripapillary retinal nerve fibre layer thinning in preclinical diabetic retinopathy

Implication of Deep-Vascular-Layer Alteration Detected by Optical Coherence Tomography Angiography for the Pathogenesis of Diabetic Retinopathy

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