Optical coherence tomography angiography-derived flow density: a review of the influencing factors

Brücher, Viktoria Constanze; Storp, Jens Julian; Eter, Nicole; Alnawaiseh, Maged

doi:10.1007/s00417-019-04553-2

Cited by 41 publications

(33 citation statements)

References 115 publications

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“…In a recent review of determining factors for VD, Brücher et al concluded that age is a strong determinant of retinal VD, and that the VD of the superficial vasculature diminishes with age. 28 On the contrary, Bazvand et al reported no significant differences in superficial peripapillary VD across different age groups (N = 79; range 12 to 67 years). 11 However, they admitted that they anticipated some VD changes, albeit mild, during ageing but that their small sample size likely precluded detecting these changes.…”

Section: Peripapillarymentioning

confidence: 91%

Normative Database of Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography and Correlation Study

Fernández‐Vigo

Kudsieh

Shi

et al. 2020

Current Eye Research

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Purpose: To provide a normative data set of swept-source optical coherence tomography angiography (SS-OCTA) peripapillary vessel density (VD) measurements and assess correlations with age, gender, disc area and axial length (AL). Material and Methods: This was an observational cross-sectional study conducted on 346 right eyes of healthy subjects. Peripapillary SS-OCTA VD measurements were obtained in the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) in all four quadrants using the Triton device (Topcon, Nagoya, Japan). AL measurements were made by optical biometry. Results: Mean participant age was 37.7 ± 19.8 years (range 5-83), AL was 23.9 ± 1.3 mm (21-27), and 59% were women. Mean VDs for all quadrants were 57.2 ± 5.7% for SCP (52.4 ± 4.0% -62.1 ± 4.2%), 46.3 ± 6.5% for DCP (41.9 ± 5.8% -49.7 ± 4.8%) and 60.8 ± 7.4% for CC (53.4 ± 5.8% -65.7 ± 5.5%). Negative correlation was detected between SCP VD and age (R = −0.264; P < .001), while correlation between DCP densities and age was positive (R = 0.202; P = .002). No associations were detected between peripapillary VD and gender (P ≥ 0.087) and negative correlation was found with AL and disc area only in the CC (P ≤ 0.004). In a subgroup analysis of 33 individuals, we noted no differences in VD between fellow eyes (P ≥ 0.139). Conclusion: Peripapillary VD showed wide individual variation when measured with the Triton SS-OCTA in the different retinal plexuses and CC. While correlations were observed with age, no relationships emerged with gender and only CC showed negative correlation with AL and disc area.

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Section: Peripapillarymentioning

confidence: 91%

Normative Database of Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography and Correlation Study

Fernández‐Vigo

Kudsieh

Shi

et al. 2020

Current Eye Research

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“…and ophthalmological variables (intraocular pressure, spherical equivalent, lens status, etc.) [22]. Since in each case the two scans compared were obtained in direct succession in the same patient, these factors probably exerted little influence.…”

Section: Plos Onementioning

confidence: 99%

Morphologic analysis of macular neovascularizations by OCT angiography—Technical limitations in the comparison of 3×3mm and 6×6mm images

et al. 2020

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Background The aim of this study was to ascertain whether there are relevant differences between the vascular morphology of macular neovascularizations (MNV) in 3×3mm and 6×6mm images, produced by optical coherence tomography angiography (OCTA). Methods MNV of 49 patients were automated quantitative analysed, measuring area, flow, the fractal dimension, average vessel length, vascular density, and average vessel caliber. These parameters were compared between the 3×3mm and the 6×6mm images. Results A strong linear association was found between the 3×3mm and the 6×6mm images. While area, flow, and FD of the MNV were very similar, the 3×3mm images showed significantly lower average total vessel length, greater vascular density, and lower average vessel caliber. Conclusion In quantitative analysis of the morphologic parameters of MNV in 3×3mm and 6×6mm images, the structures are not directly equivalent in the two sizes of scan. The images must be evaluated on an individual basis.

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“…However, FFA is an invasive examination and cannot quantify the vessel density (VD) [4]. Optical coherence tomography angiography (OCTA) is a recent non-invasive technology that can visualize and quantify the retinal and papillary microvasculature [5,6]. Studies have demonstrated abnormal blood flow changes of the retina and optic discs in some diseases, including retinal vein occlusion [7], anterior ischemic optic neuropathy [8,9], glaucoma [10], diabetic retinopathy [11,12], and hypertension retinopathy [13].…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment and determinants of the papillary microvasculature in healthy subjects

et al. 2021

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Background It is critical to monitor the optic disc’s vessel density using Optical coherence tomography angiography (OCTA) and evaluate its determinants. In the current study, we investigate the superficial vessel density (VD) of the papillary microvasculature and its determinants in healthy subjects of Southern China. Methods This was a prospective, cross-sectional study. Superficial VD in healthy individuals’ optic disc region was measured by OCTA. The factors associated with ocular and systemic parameters were analyzed using a generalized estimation equation (GEE) model. Results A total of 510 eyes of 260 healthy subjects were analyzed in the study. The total VD in the optic disc area was 17.21 ± 2.15 mm− 1 (95% CI, 17.02–17.40 mm− 1). The VD in the inner ring and the outer ring of the optic disc were significantly higher compared with the central ring, while the VD of the superior quadrant and inferior quadrant was significantly higher compared with the temporal and nasal quadrant. After adjusting for the ocular factors and systemic factors, AL (β = − 0.4917, P = 0.0003), disc area (β = − 0.3748, P = 0.0143), CMT (β = − 0.0183, P = 0.0003) and SSI (β = 1.0588, P < 0.001) were significantly associated with total VD of the optic disc. Conclusion The mean total VD in the optic disc area was 17.21 ± 2.15 mm− 1 in healthy subjects, and the superior and inferior VD was significantly higher than the temporal and nasal VD. AL, disc area, CMT, and SSI may affect the total VD in the optic disc area and should be considered in clinical practice.

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Optical coherence tomography angiography-derived flow density: a review of the influencing factors

Cited by 41 publications

References 115 publications

Normative Database of Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography and Correlation Study

Normative Database of Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography and Correlation Study

Morphologic analysis of macular neovascularizations by OCT angiography—Technical limitations in the comparison of 3×3mm and 6×6mm images

Quantitative assessment and determinants of the papillary microvasculature in healthy subjects

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