Optical coherence tomography angiography assessment of 577 nm laser effect on severe non-proliferative diabetic retinopathy with diabetic macular edema

Li, Zijing; Xiao, Jianhui; Zeng, Peng; Zeng, Rui; Gao, Xiang; Zhang, Yichi; Lan, Yuqing

doi:10.18240/ijo.2020.08.12

Cited by 8 publications

(7 citation statements)

References 28 publications

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“…Several studies have investigated the changes of macular VD after PRP treatment with OCTA. Li et al [ 8 ] found that the macular VD increased 1 day after PRP but decreased 6 months after PRP in severe NPDR eyes. Lorusso et al [ 9 ] found that PRP did not change macular VD in PDR eyes at a 6-month follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…VD is associated with DR severity and can be used to predict the treatment outcome in DR patients [ 6 ]. Prior studies have reported that the VD changes after the treatment with anti-vascular endothelial growth factor (VEGF) or PRP treatment in PDR eyes with mixed results [ 7 , 8 , 9 , 10 ]. In this study, the retinal VD was compared between anti-VEGF treatment and PRP before the treatments and 12-month after the treatments.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Effect of Pan-Retinal Photocoagulation and Intravitreal Conbercept Treatment on the Change of Retinal Vessel Density Monitored by Optical Coherence Tomography Angiography in Patients with Proliferative Diabetic Retinopathy

Zhao

Zhou

et al. 2021

JCM

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Background: This study compares the change of retinal vessel density (VD) after pan-retinal photocoagulation (PRP) and intravitreal conbercept (IVC) treatment in proliferative diabetic retinopathy (PDR) eyes with optical coherence tomography angiography (OCTA). Methods: A total of 55 treatment-naïve PDR eyes were included in this retrospective study. Of these, 29 eyes were divided into a PRP group, and 26 eyes were divided into an IVC group based on the treatment they received. OCTA was performed to measure macular and papillary VD at each follow-up in both groups. Results: The macular VD for superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC) and papillary VD for radial peripapillary capillary (RPC) between the two groups demonstrated no significant difference at baseline and month 12 (p > 0.05). The paired t-test results showed that the macular VD for SCP, DCP, CC and papillary VD for the RPC at month 12 did not differ to the baseline in each group (p > 0.05). Conclusions: During the 12-month follow-up, there was no significant change of macular and papillary VD between the PRP and IVC treatment in PDR eyes. Additionally, compared to the baseline, there were no significant changes of macular and papillary VD after either the PRP or IVC treatment. Considering the decrease in VD as DR progress, both treatments have potential protection of macular and papillary VD loss in PDR.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of the Effect of Pan-Retinal Photocoagulation and Intravitreal Conbercept Treatment on the Change of Retinal Vessel Density Monitored by Optical Coherence Tomography Angiography in Patients with Proliferative Diabetic Retinopathy

Zhao

Zhou

et al. 2021

JCM

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“…Li et al quantitatively investigated the combined effect of YSML with panretinal laser photocoagulation (PRP) on 86 eyes of 86 patients previously diagnosed with severe non-proliferative diabetic retinopathy (NPDR) with a center involving DME [ 68 ]. Several OCTA parameters, including foveal avascular zone (FAZ), capillary density (CD), CMT, choriocapillary flow area (ChF) and BCVA, were evaluated during a 6-month observational retrospective study.…”

Section: Clinical Applicationsmentioning

confidence: 99%

“…Overall, BCVA remained stable throughout the entire follow-up. CMT, macular edema, blood flow and capillary density were characterized by a decreasing trend, whereas FAZ tended to increase during the 6-month period [ 68 ].…”

Section: Clinical Applicationsmentioning

confidence: 99%

Yellow Subthreshold Micropulse Laser in Retinal Diseases: An In-Depth Analysis and Review of the Literature

et al. 2023

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Yellow subthreshold micropulse laser (YSML) is a retinal laser capable of inducing a biologic response without causing thermal damage to the targeted tissue. The 577-nm YSML is delivered to the retina abiding by different protocols in which wavelength, power, duration, spot size and number of spots can be properly set to achieve the most effective and safe treatment response in various chorioretinal disorders. The ultrashort trains of power modulate the activation of the retinal pigment epithelium cells and intraretinal cells, such as Müller cells, causing no visible retinal scars. Subthreshold energy delivered by YSML stimulates the production of the heat-shock proteins, highly conserved molecules that protect cells against any sort of stress by blocking apoptotic and inflammatory pathways that cause cell damage. YSML treatment allows resorption of the subretinal fluid in central serous chorioretinopathy and intraretinal fluid in various conditions including diabetic macular edema, postoperative cystoid macular edema and other miscellaneous conditions. YSML also seems to modulate the development and progression of reticular pseudodrusen in dry age-related macular degeneration. The aim of this review is to discuss and summarize the safety and efficacy of YSML treatment in retinal diseases.

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“…Available data on alternative subthreshold micropulse panretinal photocoagulation (PRP) in treating severe non-proliferative diabetic retinopathy and proliferative diabetic retinopathy are limited, and without studies of higher quality according to evidence-based medicine (EBM), it should be considered as experimental [73,74].…”

Section: Comparison Of Subthreshold Micropulse and Conventional Laser...mentioning

confidence: 99%

Subthreshold Micropulse Laser for Diabetic Macular Edema: A Review

Sabal

Teper

Wylęgała

2022

JCM

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Diabetic macular edema (DME) is one of the main causes of visual impairment in patients of working age. DME occurs in 4% of patients at all stages of diabetic retinopathy. Using a subthreshold micropulse laser is an alternative or adjuvant treatment of DME. Micropulse technology demonstrates a high safety profile by selectively targeting the retinal pigment epithelium. There are no standardized protocols for micropulse treatment, however, a 577 nm laser application over the entire macula using a 200 μm retinal spot, 200 ms pulse duration, 400 mW power, and 5% duty cycle is a cost-effective, noninvasive, and safe therapy in mild and moderate macular edemas with retinal thickness below 400 μm. Micropulse lasers, as an addition to the current gold-standard treatment for DME, i.e., anti-vascular endothelial growth factor (anti-VEGF), stabilize the anatomic and functional retinal parameters 3 months after the procedure and reduce the number of required injections per year. This paper discusses the published literature on the safety and application of subthreshold micropulse lasers in DME and compares them with intravitreal anti-VEGF or steroid therapies and conventional grid laser photocoagulation. Only English peer-reviewed articles reporting research within the years 2010–2022 were included.

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Optical coherence tomography angiography assessment of 577 nm laser effect on severe non-proliferative diabetic retinopathy with diabetic macular edema

Cited by 8 publications

References 28 publications

Comparison of the Effect of Pan-Retinal Photocoagulation and Intravitreal Conbercept Treatment on the Change of Retinal Vessel Density Monitored by Optical Coherence Tomography Angiography in Patients with Proliferative Diabetic Retinopathy

Comparison of the Effect of Pan-Retinal Photocoagulation and Intravitreal Conbercept Treatment on the Change of Retinal Vessel Density Monitored by Optical Coherence Tomography Angiography in Patients with Proliferative Diabetic Retinopathy

Yellow Subthreshold Micropulse Laser in Retinal Diseases: An In-Depth Analysis and Review of the Literature

Subthreshold Micropulse Laser for Diabetic Macular Edema: A Review

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