Optical Coherence Tomography Angiography and Structural Analyses of the Pale Optic Discs: Is It Possible to Differentiate the Cause?

Aghdam, Kaveh Abri; Aghajani, Ali; Razi-Khosroshahi, Marjan; Sanjari, Mostafa Soltan; Chaibakhsh, Samira; Falavarjani, Khalil Ghasemi

doi:10.1080/02713683.2021.1929331

Cited by 5 publications

(5 citation statements)

References 45 publications

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“…We found that super cial parafoveal vascular density decreased in patients with methanol toxicity, but there were no signi cant changes in deep parafoveal, peripapillary, and inside disc vascular density. However, Abri Aghdam et al (19) reported that inside disc and peripapillary vessel density were signi cantly lower in patients with methanol-induced optic neuropathy compared to normal individuals after six months of poisoning. These differences may be due to population size and length of follow-up, and age.…”

Section: Discussionmentioning

confidence: 97%

“…The present study con rmed previous reports that the RNFL thickness signi cantly decreases after poisoning. In a recent study, the cause of this decrease was attributed to changes in the optic disc and radial peripapillary capillary (RPC) vessel density (19). According to Galvez-Ruiz et al ( 16), all patients with methanol toxicity had optic nerve atrophy, and almost half of the patients had cupping (cup to disc ratio) more than 0.8 at least in one eye after one month.…”

Section: Discussionmentioning

confidence: 99%

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Time course study of optical coherence tomography angiography in patients with methanol-induced optic neuropathy

Jafarizadeh

Homaie

Abdollahi

et al. 2023

Preprint

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Introduction: In countries where alcoholic beverages are legally prohibited, methanol toxicity usually occurs due to ingesting homemade alcoholic drinks. The initial ophthalmologic symptoms of methanol toxicity typically appear 6–48 hours after ingestion, and the severity of symptoms varies widely from mild and painless decreased vision to no-light perception vision. Methods This prospective study examines 20 patients with acute methanol poisoning within 10 days of use. Patients underwent ocular examinations, BCVA (Best Corrected Visual Acuity) recording, and OCTA (Optical Coherence Tomography Angiography) of the macula and optic disc. BCVA measurement and imaging were repeated one month and three months after intoxication. Results There was a statistically significant reduction in superficial parafoveal vascular density (P-value = 0.026), inner retinal thickness (P-value = 0.022), RNFL (Retinal Nerve Fiber Layer) thickness (P-value = 0.031), and an increase in cup to disc ratio (P-value < 0.001), and central visual acuity (P-value = 0.002) in this time course. However, there was no statistically significant difference in FAZ (Foveal Avascular Zone) area (P-value = 0.309), FAZ perimeter (P-value = 0.504), FD-300 (Foveal density, vascular density within a 300µm wide region of the FAZ) (P-value = 0.541), superficial vascular density (P-value = 0.187), deep foveal vascular density (P-value = 0.889), deep parafoveal vascular density (P-value = 0.830), choroidal flow area (P-value = 0.464), total retinal thickness (P-value = 0.597), outer retinal thickness (P-value = 0.067), optic disc whole image vascular density (P-value = 0.146), vascular density inside the disc (P-value = 0.864), or peripapillary vascular density (P-value = 0.680) at different times. Conclusion Over time, methanol poisoning can cause changes in retinal layers thickness, vasculature, and optic nerve head. The most important changes include cupping of the optic nerve head, reduction in RNFL thickness, and inner retinal thickness.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Time course study of optical coherence tomography angiography in patients with methanol-induced optic neuropathy

Jafarizadeh

Homaie

Abdollahi

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…On the other hand, there was a significant decrease in inner retinal thickness, which can be a reason for the lower superficial parafoveal vascular density. However, Abri Aghdam et al [ 19 ] reported that inside disc and peripapillary vessel density were significantly lower in patients with methanol-induced optic neuropathy compared to normal individuals after six months of poisoning. These differences may be due to population size and length of follow-up, and age.…”

Section: Discussionmentioning

confidence: 99%

“…The present study confirmed previous reports that the RNFL thickness significantly decreases after poisoning. In a recent study, the cause of this decrease was attributed to changes in the optic disc and radial peripapillary capillary (RPC) vessel density [ 19 ]. According to Galvez-Ruiz et al [ 16 ], all patients with methanol toxicity had optic nerve atrophy, and almost half of the patients had cupping (cup to disc ratio) more than 0.8 at least in one eye after one month.…”

Section: Discussionmentioning

confidence: 99%

Time course study of optical coherence tomography angiography in patients with methanol induced optic neuropathy

et al. 2023

View full text Add to dashboard Cite

Introduction In countries where alcoholic beverages are legally prohibited, methanol toxicity usually occurs due to ingesting homemade alcoholic drinks. The initial ophthalmologic symptoms of methanol toxicity typically appear 6–48 h after ingestion, and the severity of symptoms varies widely from mild and painless decreased vision to no-light perception vision. Methods This prospective study examines 20 patients with acute methanol poisoning within 10 days of use. Patients underwent ocular examinations, BCVA (Best Corrected Visual Acuity) recording, and OCTA (Optical Coherence Tomography Angiography) of the macula and optic disc. BCVA measurement and imaging were repeated one month and three months after intoxication. Results There was a statistically significant reduction in superficial parafoveal vascular density (P-value = 0.026), inner retinal thickness (P-value = 0.022), RNFL (Retinal Nerve Fiber Layer) thickness (P-value = 0.031), and an increase in cup to disc ratio (P-value < 0.001), and central visual acuity (P-value = 0.002) in this time course. However, there was no statistically significant difference in FAZ (Foveal Avascular Zone) area (P-value = 0.309), FAZ perimeter (P-value = 0.504), FD-300 (Foveal density, vascular density within a 300 μm wide region of the FAZ) (P-value = 0.541), superficial vascular density (P-value = 0.187), deep foveal vascular density (P-value = 0.889), deep parafoveal vascular density (P-value = 0.830), choroidal flow area (P-value = 0.464), total retinal thickness (P-value = 0.597), outer retinal thickness (P-value = 0.067), optic disc whole image vascular density (P-value = 0.146), vascular density inside the disc (P-value = 0.864), or peripapillary vascular density (P-value = 0.680) at different times. Conclusion Over time, methanol poisoning can cause changes in retinal layers thickness, vasculature, and optic nerve head. The most important changes include cupping of the optic nerve head, reduction in RNFL thickness, and inner retinal thickness.

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“…Disc area and the cup size were larger in methanol-induced optic neuritis, and RNFL thickness was lower in traumatic optic neuritis compared to other groups. Since they did not find specific vascular changes which can differentiate between groups, they concluded that structural assessment might be superior to vascular parameters in differentiating toxic and traumatic optic neuropathies [ 56 ].…”

Section: Papilledemamentioning

confidence: 99%

The Role of Optical Coherence Tomography Angiography in Optic Nerve Head Edema: A Narrative Review

Karrabi

Hooshmandi

Amirabadi

et al. 2022

Journal of Ophthalmology

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Optic nerve head (ONH) edema is a clinical manifestation of many ocular and systemic disorders. Ocular and central nervous system imaging has been used to differentiate the underlying cause of ONH edema and monitor the disease course. ONH vessel abnormalities are among the earliest signs of impaired axonal transportation. Optical coherence tomography angiography (OCTA) is a noninvasive method for imaging ONH and peripapillary vessels and has been used extensively for studying vascular changes in ONH disorders, including ONH edema. In this narrative review, we describe OCTA findings of the most common causes of ONH edema and its differential diagnoses including ONH drusen.

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Optical Coherence Tomography Angiography and Structural Analyses of the Pale Optic Discs: Is It Possible to Differentiate the Cause?

Cited by 5 publications

References 45 publications

Time course study of optical coherence tomography angiography in patients with methanol-induced optic neuropathy

Time course study of optical coherence tomography angiography in patients with methanol-induced optic neuropathy

Time course study of optical coherence tomography angiography in patients with methanol induced optic neuropathy

The Role of Optical Coherence Tomography Angiography in Optic Nerve Head Edema: A Narrative Review

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