Optical Chirality Sensing with an Auxiliary‐Free Earth‐Abundant Cobalt Probe

Abstract

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Tandem Use of Optical Sensing and Machine Learning for the Determination of Absolute Configuration, Enantiomeric and Diastereomeric Ratios, and Concentration of Chiral Samples

“…We recently reported that chiroptical analysis of unprotected chiral amino alcohols and many other classes of compounds is possible with a simple mix-and-measure protocol using inexpensive cobalt, iron, copper and other metal salts that generate strong Cotton effects at high wavelengths. 21 The induced CD (ICD) signals were successfully correlated to the enantiomeric ratio of the sensing targets and used for quantitative er determination. These findings encouraged us to examine the possibility of using metal complexation of 3 for the same purpose.…”

Stereochemical analysis of chiral amines, diamines, and amino alcohols: Practical chiroptical sensing based on dynamic covalent chemistry

“…12 The exceptional potential of chiroptical sensing with circular dichroism (CD) probes was noticed early on by Berova and Nakanishi, who published several seminal papers with broadly useful zinc porphyrin tweezer hosts. [13][14][15][16][17][18] Their outstanding work has spurred the development of a wide variety of CD sensor designs by Borhan, [19][20][21] Canary, 22,23 Anslyn, [24][25][26][27] our group, [28][29][30][31][32][33][34][35][36][37][38] and others. [39][40][41][42][43] The large majority of CD sensing assays introduced so far relies on the formation of supramolecular assemblies, metal coordination complexes, hydrogen bond adducts, or dynamic covalent chemistry (DCC).…”

The Chirality Induction and Modulation of Polymers by Circularly Polarized Light

“…Homochirality is one of the most valuable aspects of science and is an essential molecular characteristic of terrestrial life [1][2][3][4]. Asymmetric conformation represents the chiral structure of biomacromolecules in living organisms on earth.…”