Optical biosensors based on etched fiber Bragg gratings

Fabrication of a compact reflective long-period grating sensor with a cladding-mode-selective fiber end-face mirror

“…The detection of a specific antibody or antigen was demonstrated after immobilization of biological molecules or antibody on the surface of fiber grating [8][9][10][11][12]. An FBG needs some special post-processes for sensing of external RI [13][14][15], and has practical implementation limitations, including the reduction on the sensor's mechanical strength. Tilted FBG was also utilized to measure RI sensing but its measurement resolution is only around 10 −4 [16].…”

“…Since the discovery of fiber gratings, the use of FBGs and LPGs for external RI sensing was proposed and demonstrated because of their potential applications as miniature biochemical sensors [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. The detection of a specific antibody or antigen was demonstrated after immobilization of biological molecules or antibody on the surface of fiber grating [8][9][10][11][12].…”

Recent Development in Optical Fiber Biosensors

“…In the last years, high sensitivity chemical and biological sensors based on etched core fiber Bragg gratings that detect change in the index of refraction of surrounding solutions, were developed to measure the index of refraction of different solutions [ 137 - 140 ] and compact three segmented multimode fiber modal interferometer for high sensitivity refractive-index measurement also have been described [ 141 ].…”