Optical biosensor microsystems based on the integration of highly sensitive Mach–Zehnder interferometer devices

Sepúlveda, Borja; Río, José Sánchez del; Moreno, Miguel; Blanco, F.; Mayora, Kepa; Domı́nguez, Carlos; Lechuga, Laura M.

doi:10.1088/1464-4258/8/7/s41

Cited by 169 publications

(99 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…information. [18][19][20][21] Several approaches have been considered to increase the optical path in such a waveguide configuration. Densmore et al proposed a refractive index sensor employing a folded strip waveguide which confines light in a planar structure achieving an optical path of 2 mm.…”

Section: Introductionmentioning

confidence: 99%

Integrating cell on chip—Novel waveguide platform employing ultra-long optical paths

Fohrmann¹,

Sommer²,

Pitruzzello³

et al. 2017

APL Photonics

View full text Add to dashboard Cite

Optical waveguides are the most fundamental building blocks of integrated optical circuits. They are extremely well understood, yet there is still room for surprises. Here, we introduce a novel 2D waveguide platform which affords a strong interaction of the evanescent tail of a guided optical wave with an external medium while only employing a very small geometrical footprint. The key feature of the platform is its ability to integrate the ultra-long path lengths by combining low propagation losses in a silicon slab with multiple reflections of the guided wave from photonic crystal (PhC) mirrors. With a reflectivity of 99.1% of our tailored PhC-mirrors, we achieve interaction paths of 25 cm within an area of less than 10 mm2. This corresponds to 0.17 dB/cm effective propagation which is much lower than the state-of-the-art loss of approximately 1 dB/cm of single mode silicon channel waveguides. In contrast to conventional waveguides, our 2D-approach leads to a decay of the guided wave power only inversely proportional to the optical path length. This entirely different characteristic is the major advantage of the 2D integrating cell waveguide platform over the conventional channel waveguide concepts that obey the Beer-Lambert law.

show abstract

Section: Introductionmentioning

confidence: 99%

Integrating cell on chip—Novel waveguide platform employing ultra-long optical paths

Fohrmann¹,

Sommer²,

Pitruzzello³

et al. 2017

APL Photonics

View full text Add to dashboard Cite

show abstract

“…This latter is proportional to cos (Δn 2 k o L), where Δn 2 represents the refractive index change, k o the amplitude of the wave vector and L the length of the sensitive region. These structures are made in glass or silicon and may be easily integrated into lab on chip laboratories (Sepulveda et al, 2006).…”

Section: Mach-zender Interferometersmentioning

confidence: 99%

New Trends in Biosensors for Water Monitoring

Lagarde¹,

Jaffrézic‐Renault²

2011

Environmental Biosensors

View full text Add to dashboard Cite

“…Polymer Ormocore [17,18] is used as the waveguide core, which is on the SiO 2 under the cladding. The biological sample under test, namely the analyte, covers both sensing arms, which avoids etching an extra sensing pool [19,20]. Therefore, the complexity of the waveguide device fabrication is reduced, and the sensor array integration can be easily realized.…”

Section: Introductionmentioning

confidence: 99%

Polymer integrated waveguide optical biosensor by using spectral splitting effect

Han

Shao

et al. 2017

Photonic Sens

View full text Add to dashboard Cite

Abstract:The polymer waveguide optical biosensor based on the Mach-Zehnder interferometer (MZI) by using spectral splitting effect is investigated. The MZI based biosensor has two unequal width sensing arms. With the different mode dispersion responses of the two-arm waveguides to the cladding refractive index change, the spectral splitting effect of the output interference spectrum is obtained, inducing a very high sensitivity. The influence of the different mode dispersions between the two-arm waveguides on the spectral splitting characteristic is analyzed. By choosing different lengths of the two unequal width sensing arms, the initial dip wavelength of the interference spectrum and the spectral splitting range can be controlled flexibly. The polymer waveguide optical biosensor is designed, and its sensing property is analyzed. The results show that the sensitivity of the polymer waveguide optical biosensor by using spectral splitting effect is as high as 10 4 nm/RIU, with an improvement of 2-3 orders of magnitude compared with the slot waveguide based microring biosensor.

show abstract

Optical biosensor microsystems based on the integration of highly sensitive Mach–Zehnder interferometer devices

Cited by 169 publications

References 16 publications

Integrating cell on chip—Novel waveguide platform employing ultra-long optical paths

Integrating cell on chip—Novel waveguide platform employing ultra-long optical paths

New Trends in Biosensors for Water Monitoring

Polymer integrated waveguide optical biosensor by using spectral splitting effect

Contact Info

Product

Resources

About