Optical Absorption of the Antitrypanocidal Drug Benznidazole inWater

Bezerra, Eveline M.; Bezerra-Neto, João R.; Sales, Francisco Adilson Matos; Santos, Ricardo; Martins, Alice Maria Costa; Lima‐Neto, Pedro de; Caetano, E. W. S.; Albuquerque, E.L.; Freire, V. N.

doi:10.3390/molecules19044145

Cited by 16 publications

(9 citation statements)

References 19 publications

(28 reference statements)

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“…3) showed that the BZN@CaCO 3 had an absorbance peak at 324 nm, the same observed for BZN (Bezerra et al . 2014). Through the linear interpolation of the BZN absorbance (at 324 nm) in different dilutions (calibration curve), the BZN concentration was determined in the conjugated form as being ~25%.…”

Section: Resultsmentioning

confidence: 99%

Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi

et al. 2018

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Chagas disease is a public health problem, affecting about 7 million people worldwide. Benznidazole (BZN) is the main treatment option, but it has limited effectiveness and can cause severe adverse effects. Drug delivery through nanoparticles has attracted the interest of the scientific community aiming to improve therapeutic options. The aim of this study was to evaluate the cytotoxicity of benznidazole-loaded calcium carbonate nanoparticles (BZN@CaCO3) on Trypanosoma cruzi strain Y. It was observed that BZN@CaCO3 was able to reduce the viability of epimastigote, trypomastigote and amastigote forms of T. cruzi with greater potency when compared with BZN. The amount of BZN necessary to obtain the same effect was up to 25 times smaller when loaded with CaCO3 nanoparticles. Also, it was observed that BZN@CaCO3 enhanced the selectivity index. Furthermore, the cell-death mechanism induced by both BZN and BZN@CaCO3 was evaluated, indicating that both substances caused necrosis and changed mitochondrial membrane potential.

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Section: Resultsmentioning

confidence: 99%

Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi

et al. 2018

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“…In addition, one can also determine partial atomic charges and dipole moments both of which are essential to mimic charge transfer (CT) states. 58,59 As previously mentioned, the method compliments UV-Vis spectroscopy, where the relative intensities of the optical transitions can also be determined.…”

Section: Computational Methods: Density Functional Theory (Dft)mentioning

confidence: 99%

Synthesis and structure-property studies of organic dyes possessing unique fused thiophene π-spacers

Abdinejad¹

2021

Preprint

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This thesis examines the synthesis of metal-free organic dyes for light-harvesting applications within the DSSC manifold. All DSSC organic dyes possess a similar donor-π-spacer-acceptor (D-π-A) motif. Here, triphenylamine (TPA) is employed as a donor owing to its redox stability and cyanoacetic acid has been utilized as an acceptor due to its electron-withdrawing ability. Thiophenes are ubiquitous in organic materials chemistry owing to their exceptional charge transport behavior, and in this body of work, π-spacers incorporating benzodithiophene and thiophene-quinones have been incorporated into a DSSC dye and their utility explored. Fused thiophene cores are non-innocent π-spacers. Non-innocent, in this context, is defined as π-spacers that incorporate a secondary chromophore or redox active species (benzodithiophene or quinone).

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“…Theoretical quantum chemistry methods based on HF and DFT are used for the calculation of optimized geometry, absorption spectrum, FT-IR and 1 H NMR spectra of the organic molecules. [5][6][7][8][9][10][11][12][13][14][15][16][17] In this work on the basis of PVA and new synthesized dichroic azo benzene dye A thermostable polarizing film absorbing in visible spectral range of spectrum (λ max = 550 nm) for application in Display Technologies and Optoelectronic applications was developed.…”

Section: Introduction *mentioning

confidence: 99%

Spectroscopic and thermophysical investigation of new synthesized azo dye and its application in polarizing film

Shahab¹,

Filippovich²,

Sheikhi³

et al. 2019

Rev.Roum.Chim.

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Quantum-chemical calculations using the Density Functional Theory (DFT) approach for structural analysis of a new azo benzene derivative: Sodium 6-amino-5-hydroxy-3-((E)-(2methoxy-4-((E)-(4-sulfonatophenyl)diazenyl)phenyl)diazenyl)naphthalene-2-sulfonate (A) (trans isomer) were designed using B3LYP method with 6-311++G** basis set. The electronic absorption spectrum of the A in water solution was calculated using TDB3LYP/6-311++G** method. The excitation energies, electronic transitions and oscillator strengths for studied structure have also been calculated. On the basis of calculations a new dichroic azo benzene dye A was synthesized. The experimental UV-Vis, FT-IR and 1 H NMR spectra of the title molecule were presented. On the basis of polyvinyl alcohol (PVA) and the dichroic synthesized azo benzene dye A thermostable polarizing film absorbing in the seen region of the spectrum (λ max = 550 nm) with Polarization Efficiency (PE) in the absorption maximum (λ max = 92 %) and Stretching Degree (R s) = 3.0 was developed. The experimental spectral-polarization parameters of stretched colored PVA-films were measured. During the work it was established that oriented PVA-films is phenomenon of anisotropy of thermal conductivity (λ || / λ ⊥). Thermal conductivity in a direction of orientation (λ ||) is higher than in a direction perpendicular orientations (λ ⊥).

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Optical Absorption of the Antitrypanocidal Drug Benznidazole inWater

Cited by 16 publications

References 19 publications

Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi

Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi

Synthesis and structure-property studies of organic dyes possessing unique fused thiophene π-spacers

Spectroscopic and thermophysical investigation of new synthesized azo dye and its application in polarizing film

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