Optic perineuritis secondary to Wegener's granulomatosis

Abstract

Steroid dependency in idiopathic OPN should raise suspicion of WG. Patients with OPN should be specifically questioned regarding pre-existing upper respiratory tract disorders and rheumatic symptoms and laboratory testing should include acute phase reactants, anti-neutrophil cytoplasmic antibodies and tests of renal function.

A unilateral optic perineuritis in a teenager – A case report

“…The majority of cases are isolated and idiopathic [1,2]. Syphilis, Wegener's granulomatosis, sarcoidosis, Crohn disease and leukemia have been reported as causing optic perineuritis in adult patients [3][4][5][6][7][8]. Based on a PubMed literature search, limited information is available regarding optic perineuritis in pediatric patients.…”

Primary Wegener’s Granulomatosis of the Orbital Apex with Initial Optic Nerve Infiltration

“…Intraconal or orbital apex disease usually occurs secondary to contiguous spread from this. A few reports exist of isolated orbital apex pathology, most of which describe presumed Wegener's granulomatosis-related optic perineuritis (Belden et al, 1993;Perry et al, 1997;Purvin and Kawasaki, 2009). This typically presents with painful optic neuropathy and is diagnosed by "donut" radiological enhancement of the apical optic nerves on MRI and systemic features or immunology compatible with Wegener's granulomatosis.…”

Wegener Granulomatosis-associated Optic Perineural Hypertrophy and Optic Neuropathy

“…The radiological hallmarks of the present patient did not reveal those findings. Previous reports advocated fibronecrosis and gadolinium-enhancing lesions in the optic nerve sheet (1,2). Orbital MRI of our patient highlighted another possibility that hypertrophic pachymeningitisassociated optic perineural hypertrophy could cause superficial damage of the optic nerve in WG.…”