Optic Perineuritis in Behçet Disease

Lai, Chuntao; Sun, Y. K.; Wang, Jiawei; Purvin, Valerie A.; He, Yuxin; Yang, Qinglin; Yun, Jimmy; Yin, Hongpeng; Zhu, Junping

doi:10.1097/wno.0000000000000264

Cited by 27 publications

(24 citation statements)

References 17 publications

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“…It is a great mimicker of typical ON. OPN has been reported mostly as idiopathic and isolated cases [1] although associations with other diseases such as Wegener granulomatosis [2], giant cell arteritis [3], Crohn’s disease [4], Behcet disease [5], leukemia [6] and acute retinal necrosis [7] have been reported. To the best of our knowledge, there are limited reports of OPN in patients with NMO or NMOSD.…”

Section: Discussionmentioning

confidence: 99%

Optic Perineuritis in Neuromyelitis Optica Spectrum Disorder

Kamaluddin

Tai

Hitam

et al. 2019

Cureus

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Optic perineuritis (OPN) involvement in demyelinating disease is rarely encountered. To our knowledge, this is the first reported case of bilateral OPN associated with neuromyelitis optica spectrum disorder (NMOSD). We present a case of a healthy young gentleman who presented with OPN, initially presumed to have a young stroke but later diagnosed to be NMOSD. Early neuroimaging is essential to help distinguish optic neuritis (ON), and prolonged treatment of systemic immunosuppression is the mainstay of treatment.

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Section: Discussionmentioning

confidence: 99%

Optic Perineuritis in Neuromyelitis Optica Spectrum Disorder

Kamaluddin

Tai

Hitam

et al. 2019

Cureus

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“…Medical history, physical examination, and laboratory tests 15 were used to exclude multiple sclerosis, neuromyelitis optica, sarcoidosis, and other vasculitis, as well as infectious diseases such as syphilis, tuberculosis, and herpes virus.…”

Section: Methodsmentioning

confidence: 99%

“…The International Criteria for Behçet’s Disease (ICBD) integrated neurological manifestations into a scoring system 14 and is helpful for early diagnosis of primary optic neuropathy in Behçet’s syndrome. Lai et al 15 reported 10 Chinese patients who met ICBD (see online supplementary Table 1) and demonstrated optic perineuritis on MRI imaging. The current study collected the data of patients with primary optic neuropathy in Behçet’s syndrome meeting ICBD to report their clinical characteristics, MRI findings, and short-term visual prognosis.…”

Section: Introductionmentioning

confidence: 99%

Primary optic neuropathy in Behçet’s syndrome

et al. 2018

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“…Optic perineuritis (OPN), a rare disease in clinic, is an in ammatory disorder characteristic of the optic nerve sheath enhancement, which was rstly reported by Purvin in 1883 1,2 . Most OPN were unilateral idiopathic, and some patients were associated with infection and autoimmune diseases [3][4][5][6][7][8][9][10][11][12][13][14] , speci cally including Behçet syndrome 3,4 , syphilis 5 , herpes zoster 6 , tuberculosis 7 , sarcoidosis [8][9] , Wegener granulomatosis 10 , giant cell arteritis 11 and Crohn's disease 12 and so on 13,14 . And the hyaluronic acid injections can also cause OPN 15 .…”

Section: Introductionmentioning

confidence: 99%

MOG Antibody Positive Optic Perineuritis: an Observational Study in Han Chinese

Meng¹,

Wang²,

Liu³

et al. 2021

Preprint

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ObjectiveTo shed light on the clinical characteristics, magnet resonance imaging(MRI) changes, and prognosis of myelin oligodendrocyte glycoprotein antibody (MOG-IgG) positive OPN in Han Chinese.MethodsWe observed 39 MOG-IgG positive patients in our ward from January 1, 2017 , to December 31, 2019. Twenty patients met OPN inclusion criteria included contrast enhancement surrounding the optic nerve, and at least one of the following clinical symptoms: 1) reduction of visual acuity, 2) impairment of visual field, and 3) eye pain. Single course group(n=11) and recurrence group(n=9) were used for comparison. Outcome variables included Wingerchuk visual acuity classification.Results Of the 20 patients with MOG-IgG positive OPN, 12(60%) were women. Ten cases (50%) presented with bilateral and 17 eyes (56.67%) with severe visual loss (SVL,≤ 0.1). Twenty-one(70.00%) eyes showed edema of optic disc. Twenty-five eyes (83.3%) had longitudinally extensive perineural enhancement. At follow-up, 4 (13%) eyes still had SVL, while 26 (87%) eyes had no SVL, and of the 19 ON patients, 3 (9%) eyes still had SVL. Seven patients (35.00%) experienced at least a relapse(median interval 13.5 months ), and of the 19 ON cases, 4 (21%) patients experienced relapse. The relapse occurred more often in younger patients than the older (mean year: 38.00 vs. 45.54 years; P = 0.025). There were no optic chiasm and brainstem lesions.ConclusionsMOG-IgG positive OPN in Han Chinese often causes severe bilateral visual loss and longitudinally extensive perineural lesion. Younger patients are more likely to relapse. Optic chiasm and brainstem lesions were relatively rare.

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Optic Perineuritis in Behçet Disease

Cited by 27 publications

References 17 publications

Optic Perineuritis in Neuromyelitis Optica Spectrum Disorder

Optic Perineuritis in Neuromyelitis Optica Spectrum Disorder

Primary optic neuropathy in Behçet’s syndrome

MOG Antibody Positive Optic Perineuritis: an Observational Study in Han Chinese

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