Optic Perineuritis and Its Association With Autoimmune Diseases

Li, Hongyang; Zhou, Hang; Sun, Jiao; Wang, Yanling; Wang, Zhenchang; Li, Jing

doi:10.3389/fneur.2020.627077

Cited by 16 publications

(13 citation statements)

References 31 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, meningeal lesions affect the ONS. 12 Previous cases have indicated that the ONS and optic nerve are associated with carcinoma through paraneoplastic syndrome 13 and metastasis. 14,15 Metastasis of meningeal lesions also affects the ONS and optic nerve.…”

Section: Discussionmentioning

confidence: 99%

Application of optic neuro‐ophthalmology imaging in latent meningeal metastases of lung cancer

Song

Chang

et al. 2021

Thoracic Cancer

Self Cite

View full text Add to dashboard Cite

Latent intracranial meningeal metastases (IMM) of lung cancer is difficult to determine, yet it is critical to do so given that it impacts the treatment agent. Studies on this disease are rare, thus necessitating further investigation. As a case study, we will explore the application of optic neuroimaging in IMM. A 62-year-old female patient was diagnosed with lung adenocarcinoma, which had progressed to osseous metastasis. During the course of chemotherapy, the patient had bilateral vision loss and paralysis of extraocular muscles. Ophthalmologists ruled out disease of the retina and suspected intracranial metastasis; however, brain-enhanced magnetic resonance angiography and magnetic resonance venography were normal. Given the patient's severe osteoarthropathy and poor physical condition, she refused to undergo a lumbar puncture examination. Optic neuro-ophthalmology imaging was ultimately used. Utilizing optical coherence tomography, we found that the basement membrane layer in the papilledema was protruding up towards the vitreous cavity. To assist in visualization, the optic nerve sheath was enhanced with optic magnetic resonance imaging. With these methods, the dural metastasis was identified, the treatment agent was changed for the patient, and she had a successful recovery. Thus, optic neuroophthalmology imaging should be recommended for patients who are in the latent course of dural metastasis, and it could also be used to evaluate therapeutic efficacy.

show abstract

Section: Discussionmentioning

confidence: 99%

Application of optic neuro‐ophthalmology imaging in latent meningeal metastases of lung cancer

Song

Chang

et al. 2021

Thoracic Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…Enhancement of the optic nerve sheath on axial and coronal post-contrast images suggested optic perineuritis. 12 …”

Section: Methodsmentioning

confidence: 99%

SARS-CoV-19-associated Rhino-orbital and cerebral mucormycosis: clinical and radiological presentations

et al. 2022

View full text Add to dashboard Cite

We describe presenting clinical and imaging manifestations of SARS-CoV-19-associated rhino-oculo-cerebral mucormycosis (ROCM) in a hospital setting during the second wave of SARS-CoV-19 pandemic in India. Data on the presenting manifestations was collected from March 01 to May 31, 2021. Associations between clinical and imaging findings were explored, specifically: (1) the presence or absence of orbital pain and infiltration of superior orbital fissure on imaging; (2) the presence of unilateral facial nerve palsy and pterygopalatine fossa infiltration and geniculate ganglion signal on contrast magnetic resonance imaging and (3) vision loss and optic nerve findings on imaging. Orbital pain was reported by six of 36 subjects. A fixed, frozen eye with proptosis and congestion was documented in 26 (72%), complete vision loss in 23 (64%) and a unilateral lower motor neuron facial nerve palsy in 18 (50%). No association was found between the presence of orbital pain and superior orbital fissure infiltration on imaging. The ipsilateral geniculate ganglion was found to enhance more profoundly in seven out of 11 subjects with facial palsy and available MR imaging, and the ipsilateral pterygopalatine fossa was found infiltrated in 14. Among 23 subjects with complete loss of vision, nine (39%) demonstrated long-segment bright signal in posterior optic nerve on diffusion MR images. We conclude that orbital pain might be absent in SARS-CoV-19-associated ROCM. Facial nerve palsy is more common than previously appreciated and ishaemic lesions of the posterior portion of the optic nerve underlie complete vision loss.

show abstract

“…Recently, a case of anti-Asialo GM1 antibody-positive optic nerve and OPN in chronic inflammatory demyelinating polyneuropathy was reported [34]. In Graves’ disease in addition to prominent thickening and protrusion of extraocular muscles, orbital fat inflammation, and abnormal enhancement on the attachment point of the extraocular muscle was always associated with inflammation of the optic nerve sheath [12 ▪ ].…”

Section: Etiologymentioning

confidence: 99%

“…Central vision is usually spared. Visual field defects may include enlarged blind spots, arcuate and paracentral scotomas, peripheral island and altitudinal defects, and, rarely, central defects [4,8 ▪ ,12 ▪ ,15]. One case reported binasal hemianopia in bilateral OPN with presumed sarcoidosis, attributed to irreversible ischemic change in bilateral uncrossed optic nerve fibers [15].…”

Section: Clinical Featuresmentioning

confidence: 99%

Optic perineuritis

Saitakis

Chwalisz

2022

Current Opinion in Ophthalmology

View full text Add to dashboard Cite

Purpose of reviewThis review paper aims at discussing pathogenesis, etiology, clinical features, management, and prognosis of OPN.Recent findingsOptic perineuritis (OPN) is an inflammatory process primarily involving the optic nerve sheath. Clinically, OPN usually presents with unilateral, gradual decline of visual function, eye pain, and/or pain on eye movements, disc edema and various features of optic nerve dysfunction, including visual field defects. It can mimic typical optic neuritis. In most cases of OPN, the disease is isolated with no specific etiology being identified, however, it can also occur secondary to a wide range of underlying systemic diseases. OPN is clinically diagnosed and radiologically confirmed based on the finding of circumferential perineural enhancement of the optic nerve sheath on magnetic resonance imaging (MRI).SummaryUnlike optic nerve, OPN is not typically self-limited without treatment. High-dose oral corticosteroids are the mainstay of treatment in OPN. The initiation of therapy usually causes rapid and dramatic improvement in signs and symptoms. In general, OPN usually has a relatively good visual prognosis, which is influenced by delays between the onset of visual loss and the initiation of steroid therapy as well as the presence of underlying systemic diseases.

show abstract

Optic Perineuritis and Its Association With Autoimmune Diseases

Cited by 16 publications

References 31 publications

Application of optic neuro‐ophthalmology imaging in latent meningeal metastases of lung cancer

Application of optic neuro‐ophthalmology imaging in latent meningeal metastases of lung cancer

SARS-CoV-19-associated Rhino-orbital and cerebral mucormycosis: clinical and radiological presentations

Optic perineuritis

Contact Info

Product

Resources

About