Optic pathways tuberculoma mimicking glioma: case report

Souto, Antônio Aversa do; Fonseca, Alexandre Brasil; Gadelha, Mônica R.; Donangelo, Inês; Chimelli, Leila; Domingues, Flavio S.

doi:10.1016/s0090-3019(03)00133-2

Cited by 14 publications

(5 citation statements)

References 16 publications

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“…3 Few authors suggest role of neurosurgical decompression of optic chiasma by excision of optochiasmatic tuberculoma if corticosteroids have failed to provide vision improvement. 12,16,17 The outcome of optochiasmatic tuberculoma is variable. After completion of 9 months of follow-up, vision improvement was complete in 3 patients and partial in 3 patients.…”

Section: Discussionmentioning

confidence: 99%

Paradoxical vision loss associated with optochiasmatic tuberculoma in tuberculous meningitis: A report of 8 patients

Sinha

Garg

Anuradha

et al. 2010

Journal of Infection

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Section: Discussionmentioning

confidence: 99%

Paradoxical vision loss associated with optochiasmatic tuberculoma in tuberculous meningitis: A report of 8 patients

Sinha

Garg

Anuradha

et al. 2010

Journal of Infection

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“…2) [18], [23], [24], [25]. Caseating granulomas, soft tissue tuberculomas, and diffuse orbital involvement can also occur in both children and adults [20], [26], [27]. Finally, orbital apex syndrome has been reported, which can lead to severe vision loss [28].…”

Section: Review Of the Literaturementioning

confidence: 99%

Orbital and external ocular manifestations of Mycobacterium tuberculosis: A review of the literature

Dalvin

Smith

2016

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Tuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis that most commonly affects the lungs. However, extrapulmonary manifestations of TB can affect the eye and surrounding orbital tissues. TB can affect nearly any tissue in the eye, and a high index of suspicion is required for accurate diagnosis. Systemic anti-tuberculosis treatment is required in cases of ocular TB, and steroids are sometimes necessary to prevent tissue damage secondary to inflammation. Delays in diagnosis are common and can result in morbidities such as loss of an affected eye. It is important for ophthalmologists and infectious disease specialists to work together to accurately diagnose and treat ocular TB in order to prevent vision loss. This article reports the various known presentations of orbital and external ocular TB and reviews important elements of diagnosis and treatment.

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“…Extensive tuberculous optic nerve involvement with radiological appearance simulating an optic nerve glioma has also been reported. [5] Differential diagnosis for an optic nerve granuloma in immunocompromised hosts should also include toxoplasmosis, cryptococcosis, lymphoma, and less likely cytomegalovirus. [6]…”

Section: Discussionmentioning

confidence: 99%

Radiological evolution and delayed resolution of an optic nerve tuberculoma: Challenges in diagnosis and treatment

Sivadasan

Alexander

Mathew

et al. 2013

Ann Indian Acad Neurol

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Optic nerve tuberculomas are rarely reported and their natural history, prognosis, and duration of required treatment remain unclear. A 40-year-old immunocompetent male presented with complete loss of vision in his right eye, which had evolved over 6 weeks. He had optic atrophy on examination. Initial imaging showed right optic nerve swelling and thickening suggesting an infiltrative inflammatory optic neuropathy (infectious or noninfectious). Serial imaging revealed appearance of ring enhancement with a necrotic centre. Biopsy and culture of the coexistent parietal lobe lesion revealed Mycobacterium tuberculosis. Persistent optic nerve granuloma with evidence of radiological improvement was noted at 18 months follow-up with antituberculous therapy (ATT). Visual recovery could not be achieved. The salient features in this case include the clinical presentation initially mimicking an infiltrative or compressive optic neuropathy, rapidradiological evolution into a tuberculoma, subtle paradoxical radiological worsening after initiation of ATT and persistence of granuloma on follow up scan. The challenges involved in early diagnosis and during the treatment course will be discussed.

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Optic pathways tuberculoma mimicking glioma: case report

Cited by 14 publications

References 16 publications

Paradoxical vision loss associated with optochiasmatic tuberculoma in tuberculous meningitis: A report of 8 patients

Paradoxical vision loss associated with optochiasmatic tuberculoma in tuberculous meningitis: A report of 8 patients

Orbital and external ocular manifestations of Mycobacterium tuberculosis: A review of the literature

Radiological evolution and delayed resolution of an optic nerve tuberculoma: Challenges in diagnosis and treatment

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