Optic neuritis in dogs: 96 cases (1983‐2016)

Abstract

Optic neuritis was most commonly associated with multifocal MUE or was isolated as the sole neurologic finding, with a similar incidence between the two groups. Findings suggest that a clinical syndrome of isolated optic neuritis, distinct from multifocal MUE, occurs in dogs.

Presumed optic neuritis of non‐infectious origin in dogs treated with immunosuppressive medication: 28 dogs (2000‐2015)

“…This is similar to reported GME cases, in which middle-aged small-breed dogs are commonly affected (O'Neill et al 2005). In contrast, large-breed dogs were most commonly affected by ON in another study (Smith et al 2017). Therefore, further studies are necessary to determine whether a breed predisposition exists.…”

“…Prognosis has generally been considered guarded for recovery of vision in dogs with ON. In previous studies, 30-33% of dogs diagnosed with ON recovered partial or complete vision after starting therapy (Davidson et al 2002, Smith et al 2017. In contrast, our results showed a partial or complete recovery of vision in response to treatment in 64% of dogs.…”

“…Similar findings were found in another study, where ONH swelling and elevation were described in all dogs (n = 50) diagnosed with ON (Davidson et al 2002). In another retrospective study (n = 96), fundoscopic findings included ONH elevation (n = 96), peripapillary retinal oedema or separation (n = 37), retinal haemorrhage or dilation of retinal vasculature (n = 23) and multiple inflammatory foci in the peripapillary region (n = 13) (Smith et al 2017).…”

“…The second study reported that only 2 of 13 dogs demonstrated pathologic CSF alterations (Armour et al 2011). The third study included 96 dogs grouped into I-ON, multifocal meningoencephalitis of unknown origin (MUE), microbial infection, neoplasia, orbital inflammation and suspected ivermectin toxicosis (Smith et al 2017). Forty-two cases were diagnosis with I-ON, with these subdivided into 17 confirmed and 25 unconfirmed cases.…”

“…In another retrospective study (n = 96), fundoscopic findings included ONH elevation (n = 96), peripapillary retinal oedema or separation (n = 37), retinal haemorrhage or dilation of retinal vasculature (n = 23) and multiple inflammatory foci in the peripapillary region (n = 13) (Smith et al . 2017).…”