Optic nerve metastasis caused by lung adenocarcinoma

Pardines, F. Hernández; Martín, J.C. Molina; Montalvo, L. Fernández; Marroquí, A. Juárez

doi:10.1016/j.oftale.2017.09.004

Cited by 3 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lung cancer may metastasize to the orbit relatively early in the disease course, and the ONS could be involved. 16,17 While carcinoma metastasis to intracranial meningioma is rare, metastasis to intracranial meningioma could be caused by the ONS. 18 The orbit MRI revealed that the enhancement of the ONS mimicked optic nerve meningioma.…”

Section: Discussionmentioning

confidence: 99%

Application of optic neuro‐ophthalmology imaging in latent meningeal metastases of lung cancer

Song

Chang

et al. 2021

Thoracic Cancer

View full text Add to dashboard Cite

Latent intracranial meningeal metastases (IMM) of lung cancer is difficult to determine, yet it is critical to do so given that it impacts the treatment agent. Studies on this disease are rare, thus necessitating further investigation. As a case study, we will explore the application of optic neuroimaging in IMM. A 62-year-old female patient was diagnosed with lung adenocarcinoma, which had progressed to osseous metastasis. During the course of chemotherapy, the patient had bilateral vision loss and paralysis of extraocular muscles. Ophthalmologists ruled out disease of the retina and suspected intracranial metastasis; however, brain-enhanced magnetic resonance angiography and magnetic resonance venography were normal. Given the patient's severe osteoarthropathy and poor physical condition, she refused to undergo a lumbar puncture examination. Optic neuro-ophthalmology imaging was ultimately used. Utilizing optical coherence tomography, we found that the basement membrane layer in the papilledema was protruding up towards the vitreous cavity. To assist in visualization, the optic nerve sheath was enhanced with optic magnetic resonance imaging. With these methods, the dural metastasis was identified, the treatment agent was changed for the patient, and she had a successful recovery. Thus, optic neuroophthalmology imaging should be recommended for patients who are in the latent course of dural metastasis, and it could also be used to evaluate therapeutic efficacy.

show abstract

Section: Discussionmentioning

confidence: 99%

Application of optic neuro‐ophthalmology imaging in latent meningeal metastases of lung cancer

Song

Chang

et al. 2021

Thoracic Cancer

View full text Add to dashboard Cite

show abstract

“…Ocular metastasis occurs in the choroid (88%), iris (9%), ciliary body (2%), and retina (less than 1%) [ 8 ]. Optic nerve metastasis is not common, and it is usually an extension from the choroid, orbit, or central nervous system [ 9 ]. The case series involving 227 patients with ocular metastases done by Ferry and Font reported metastatic optic nerve compromise in only three cases (1.3%).…”

Section: Discussionmentioning

confidence: 99%

“…Pain is usually not a chief complaint unless there is an extensive intraocular tumor [ 1 ]. Hernandez et al reported a case of isolated optic nerve metastasis in patients with lung adenocarcinoma who presented with a sudden loss of visual acuity [ 9 ]. Our patient’s first manifestation was painless visual impairment prior to the diagnosis of an underlying malignancy, which may have been misdiagnosed as the patient also had stroke symptoms.…”

Section: Discussionmentioning

confidence: 99%

Optic Nerve Metastasis in Lung Adenocarcinoma

Mangalathevi,

Azhany,

Wan Hitam

et al. 2024

Cureus

View full text Add to dashboard Cite

In this article, we report a rare case of an optic nerve metastasis secondary to lung adenocarcinoma. The ocular manifestation was the first clinical sign of the disease, and further investigation led to the diagnosis of the underlying malignancy. A 59-year-old woman presented with progressive blurring of vision in the right eye for the past month. She had been having headaches for the past two weeks and left upper limb weakness for one day. She also had loss of appetite and weight for the past few months. She looked lethargic. On presentation, her bilateral eye vision was 6/18. Both anterior segments were unremarkable. Fundoscopy showed a normal optic disc in both eyes. A nervous system examination showed mild motor sensory impairment over the left upper and lower limbs and also impairment of cranial nerves V and VII. Brain computed tomography was conducted and revealed soft tissue lesions at the lateral aspect of the optic nerve and multiple recent cerebral infarcts. Brain and orbital magnetic resonance imaging showed a metastasis intraconal lesion at the right intraorbital segment of the optic nerve. CT thorax, abdomen, and pelvis were done. The finding revealed carcinoma of the left lung with distant metastasis. The patient’s general condition deteriorated in less than two weeks. The family refused further intervention. The patient died three months after the initial presentation.

show abstract

“…The nerve sheath and three layers of meninges protect the optic nerve. Metastasis also plagues the ONS and optic nerve 10,11 . Lung cancer often results in blood metastasis, which is facilitated by damage to the blood–brain barrier.…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis also plagues the ONS and optic nerve. 10,11 Lung cancer often results in blood metastasis, which is facilitated by damage to the blood-brain barrier. The anatomical structures of the optic nerve sheath and meninges are the same with the same metastasis pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Association of optic nerve sheath lesion and brain or meningeal metastasis caused by lung cancer

Song

Chang

et al. 2022

Thoracic Cancer

View full text Add to dashboard Cite

Background With the development of imaging, the etiology of ocular lesions caused by lung cancer was not found only intraocular. Neuro‐ophthalmological imaging has been found to be useful for the diagnosis of meningeal carcinomatosis, although few studies have previously been published. Our study used magnetic resonance imaging (MRI) to determine if there was a the relationship between ocular symptoms and lung cancer metastasis. Methods We carried out a retrospective analysis which included patients with ocular lesions and lung cancer on which orbit MRI was performed together with ocular examination during January 2014 to January 2022. Here, we describe the characteristics of intraocular metastasis and optic nerve sheath lesions. Results A total of 21 lung cancer patients had ocular lesions, of which eight cases had choroidal metastasis; a further eight patients had optic nerve sheath lesions. There was one case (12.5%) of choroidal metastasis with brain or meningeal metastasis, and eight cases (100%) with optic nerve sheath lesions with brain or meningeal metastasis. A total of 75.0% patients with choroidal metastasis did not have any history of known lung cancer, and 25.0% of optic nerve sheath lesions in patients were found before a meningeal metastasis diagnosis. The features of optic nerve sheath lesions included thickening and strengthening of the long segment of the orbital optic nerve sheath with a clear boundary. Conclusions The pathway of choroidal and optic nerve sheath lesions was different. Optic nerve sheath lesions were associated with brain and meningeal metastasis. When lung cancer‐induced meningeal metastasis is suspected, orbital MRI is recommended to assist in the diagnosis.

show abstract

Optic nerve metastasis caused by lung adenocarcinoma

Cited by 3 publications

References 9 publications

Application of optic neuro‐ophthalmology imaging in latent meningeal metastases of lung cancer

Application of optic neuro‐ophthalmology imaging in latent meningeal metastases of lung cancer

Optic Nerve Metastasis in Lung Adenocarcinoma

Association of optic nerve sheath lesion and brain or meningeal metastasis caused by lung cancer

Contact Info

Product

Resources

About