Optic Disc Torsion Direction Predicts the Location of Glaucomatous Damage in Normal-Tension Glaucoma Patients with Myopia

Park, Hae‐Young L.; Lee, Kook; Park, Chan Kee

doi:10.1016/j.ophtha.2012.03.006

Cited by 189 publications

(171 citation statements)

References 26 publications

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“…22,24,25 When we compared our tilted and nontilted optic disc groups, the degree of torsion was significantly different between them.…”

Section: Discussionmentioning

confidence: 95%

“…This explanation can be summarized as glaucomatous changes or glaucoma-like changes in the tilted optic disc, which may be associated with myopic changes that occur during childhood or adolescence. 11,23,24 If this is true, two questions remain. First, why nontilted myopic optic discs did not demonstrate tilting during axial elongation and why nontilted myopic optic discs are more prone to progressive glaucomatous change?…”

Section: Discussionmentioning

confidence: 99%

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Implications of Optic Disc Tilt in the Progression of Primary Open-Angle Glaucoma

Lee

Sung

Lee

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To evaluate the effect of optic disc tilt on the progression of glaucoma in myopic glaucomatous eyes.METHODS. The disc tilt ratio was estimated on disc photographs. Glaucomatous progression was determined either by stereoscopic optic disc/retinal nerve fiber layer photographs or serial visual field data. All participants were categorized into two groups according to tilt ratio (nontilted [<1.3] or tilted [ ‡1.3]). Kaplan-Meier life-table analysis was used to compare the survival experiences (time to confirmed glaucomatous progression) between groups. The hazard ratios (HRs) for the associations between potential risk factors and progression were determined by using Cox proportional hazards modeling. RESULTS.A total of 85 eyes in 85 myopic glaucoma patients (axial length > 24 mm; mean follow-up, 4.1 years) were included. Among them, 42 eyes (49.4%) demonstrated progression and 43 eyes (50.6%) were stable on follow-up. The mean disc tilt ratio was significantly smaller, and the prevalence of disc hemorrhage higher, in the progression than the stable group (P ¼ 0.032, P ¼ < 0.001, respectively). The cumulative probability of progression was 24.7% in the tilted group and 68.7% in the nontilted group (P ¼ 0.005). Disc hemorrhage (HR ¼ 3.317; P ¼ 0.001) and the tilt ratio (HR ¼ 0.110; P ¼ 0.046) were predictive of progression. CONCLUSIONS.Myopic eyes with tilted disc demonstrated a smaller probability of glaucomatous progression. Optic disc tilt may be protective against glaucoma progression, or tilted myopic glaucomatous eyes may have less progressive characteristic by nature.

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“…22,24,25 When we compared our tilted and nontilted optic disc groups, the degree of torsion was significantly different between them.…”

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Implications of Optic Disc Tilt in the Progression of Primary Open-Angle Glaucoma

Lee

Sung

Lee

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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“…11 Digital retinal photographs centered on the optic disc and macula were obtained using standardized settings with a non-mydriatic retinal camera (Canon). Optic disc tilt, torsion, and PPA area were measured from these photographs by a glaucoma specialist (HYP) using National Institutes of Health image analysis software (ImageJ 1.40; available from http://rsb.info.nih.gov/ij/ index.html; developed by Wayne Rasband, National Institutes of Health, Bethesda, MD, USA).…”

Section: Subjectsmentioning

confidence: 99%

“…10 In the previous study, we demonstrated that the direction of optic disc torsion is related to the location of glaucomatous damage in normal tension glaucoma (NTG) with myopia. 11 We proposed that optic disc torsion and its relationship with the location of the VF defect in myopic NTG eyes may be related to eyeball growth in myopia. However, our previous study did not use direct observation of the posterior part of the eye.…”

Section: Introductionmentioning

confidence: 99%

Posterior staphyloma is related to optic disc morphology and the location of visual field defect in normal tension glaucoma patients with myopia

Park

Jung

Park

2014

Eye

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Purpose To determine the morphologic features of the optic disc and the location of visual field (VF) defect in relation to posterior staphyloma in normal tension glaucoma (NTG) eyes with myopia. Methods One hundred and thirty-four NTG patients with myopia were enrolled. B-scan ultrasonography was performed in enrolled patients. Disc tilt ratio, disc torsion, and area of peripapillary atrophy were measured from disc photographs. Patients were classified according to the presence of posterior staphyloma and its location: staphyloma involving the optic disc, staphyloma involving either the supero-temporal side of the optic disc or the infero-temporal side of the optic disc. The relationship between the location of the posterior staphyloma and that of the VF defect was analyzed. Results Among 134 eyes, 74 eyes (55.2%) had posterior staphyloma on B-scan ultrasonography. Mean torsion degree was significantly greater in eyes with staphyloma involving the temporal side of the optic disc (19.78±18.001) compared with eyes with staphyloma involving the optic disc (4.65±4.921, P ¼ 0.001). The frequency of the location of VF damage differed significantly between eyes with staphyloma involving the supero-temporal side and those involving the infero-temporal side of the optic disc (P ¼ 0.008), which was not significant in eyes with staphyloma involving the optic disc (P ¼ 0.813).Conclusions Optic disc torsion was a prominent finding in myopic NTG eyes when posterior staphyloma was located temporal to the optic disc. The location of posterior staphyloma was related to the direction of disc torsion and the location of VF defect.

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“…14 However, the correlation between optic tilt and glaucoma remains controversial. 13,15,16 Recent advances in imaging technologies, such as sweptsource OCT (SS-OCT), facilitate visualization of posterior deformities in highly myopic eyes. 17 Swept-source OCT has a longer wavelength light source and is as fast as 100,000 Ascans/second.…”

mentioning

confidence: 99%

Analysis of Peripapillary Geometric Characters in High Myopia Using Swept-Source Optical Coherence Tomography

Asai

Ikuno

Kikawa

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Optic Disc Torsion Direction Predicts the Location of Glaucomatous Damage in Normal-Tension Glaucoma Patients with Myopia

Cited by 189 publications

References 26 publications

Implications of Optic Disc Tilt in the Progression of Primary Open-Angle Glaucoma

Implications of Optic Disc Tilt in the Progression of Primary Open-Angle Glaucoma

Posterior staphyloma is related to optic disc morphology and the location of visual field defect in normal tension glaucoma patients with myopia

Analysis of Peripapillary Geometric Characters in High Myopia Using Swept-Source Optical Coherence Tomography

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