Optic disc size and progression of visual field damage in patients with normal-tension glaucoma

Hayamizu, Fukuko; Yamazaki, Yoshio; Nakagami, Takako; Mizuki, Kenji

doi:10.2147/opth.s42468

Cited by 5 publications

(2 citation statements)

References 22 publications

(16 reference statements)

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“…A single follow-up visit was conducted after three months of initial diagnosis similar to the method of Hayamizu et al [26]. Glaucoma was diagnosed according to the following characteristics:…”

Section: Methodsmentioning

confidence: 99%

Prevalence and Predictors of Ocular Complications in Obstructive Sleep Apnea Patients: A Cross-sectional Case-control Study

Morsy¹,

Amani²,

Magda³

et al. 2019

TORMJ

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Purpose:This study sought to identify the magnitude and the possible risk factors of ocular complications in patients with Obstructive Sleep Apnea (OSA).Methods:A hospital-based cross-sectional study with a nested case-control design was conducted. Qualifying study subjects were patients who had been diagnosed with moderate to severe OSA (AHI index of ≥ 5, n=80), and control subjects (n=20) who had an AHI index of ≤ 5 (“normal”). Study participants were recruited from Mansoura University Hospital’s Sleep Disorders Clinic in Mansoura, Egypt.Selected subjects were assessed for ocular complications at Mansoura Univerity Hospital Ophthalmic Center, (Mansoura), Egypt. An ophthalmic history was recorded, and opthalmic testing was carried out. The testing included unaided visual acuity measurement, refraction, best-corrected visual acuity measurement, slit lamp bio-microscopic evaluation of the anterior segment and anterior segment photography, dilated fundus examination, intraocular pressure measurement, fundus photo, and fluorescein angiography, and visual field assessment. Various tests of OSA symptoms were also monitored, including the AHI, lowest oxygen concentrations and desaturation index plus the overall severity index. .Results:It was found that OSA patients n=28 (35%), n=24 (30%), n=4 (5%) had senile cataract, normal tension glaucoma, and retinal ischemia, respectively, with an overall prevalence of 45%. Additionally, the OSA group had seven times greater risk (OR=7.36, 95%CI: 1.6-33.86) of vision-threatening disorders compared to the controls. OSA patients were observed to be at a greater risk of senile cataract 28 (35%), normal tension glaucoma 24 (30%), retinal ischemia 4 (5%) and conjunctival hyperemia and dry eye (OR=3.77, 95%CI: 1.02-13.95, OR=4.36, 95%CI: 1.26-17.08). Also, multivariate logistic regression analysis testing showed that the lowest oxygen saturation index was the only significant predictor negatively associated with vision-threatening disorders (OR=0.84, 95%CI: 0.75-0.93).Conclusion:The risk of vision-threatening and non-threatening ocular disorders is higher among OSA cases. The lowest oxygen saturation index was the only significant predictor of vision-threatening disorders. These findings support the recommendation that a full ophthalmic examination should be carried out on patients with confirmed OSA.

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Section: Methodsmentioning

confidence: 99%

Prevalence and Predictors of Ocular Complications in Obstructive Sleep Apnea Patients: A Cross-sectional Case-control Study

Morsy¹,

Amani²,

Magda³

et al. 2019

TORMJ

View full text Add to dashboard Cite

show abstract

“…Similarly, previously published data from this cohort of children reported that Aboriginal and Torres Strait Islander children had a thinner CCT (mean difference 9 µm) and a lower IOP (mean difference 1.3 mm Hg) compared with non-Indigenous children. 18 Given that numerous studies have shown an association between both thin CCT and larger ONHs with an increased risk of developing glaucoma in adulthood, [14][15][16][35][36][37][38][39] it is surprising that the limited available evidence suggests that Aboriginal and Torres Strait Islander adults exhibit low rates of glaucoma. 40,41 Current estimates on the prevalence of glaucoma in Aboriginal and Torres Strait Islander adults vary between 0.5% and 2.2% 6,40,41 compared with 1.8% to 3.0% among non-Indigenous Australians, 42,43 although it should be noted that the quality of evidence regarding the prevalence of glaucoma in Aboriginal and Torres Strait Islander adults is limited by variable testing protocols and lack of stringent and robust diagnostic criteria.…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography–Derived Measurements of the Optic Nerve Head Structure of Aboriginal and Torres Strait Islander Children

Cox,

Read,

Hopkins

et al. 2023

Journal of Glaucoma

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Purpose: To examine the optic nerve head (ONH) characteristics of visually normal Aboriginal and Torres Strait Islander children and non-Indigenous Australian children. Précis: This study demonstrated significant differences in optic nerve head characteristics in Aboriginal and Torres Strait Islander compared to non-Indigenous children which has implications for glaucoma risk and diagnosis in Aboriginal and Torres Strait Islander populations. Patients and Methods: Spectral domain optical coherence tomography (OCT) imaging was performed on the right eye of 95 Aboriginal and Torres Strait Islander children and 149 non-Indigenous Australian children (5–18 years). Horizontal and vertical line scans, centred on the ONH were analysed to determine the dimensions of the ONH (Bruch’s membrane opening diameter (BMOD)), optic cup diameter, Bruch’s membrane opening minimum rim width (BMO-MRW), and the peripapillary retinal nerve fibre layer (RNFL) thickness). Results: The vertical but not horizontal BMOD of Aboriginal and Torres Strait Islander children was significantly larger than non-Indigenous children (mean difference: 0.09 mm, P = 0.001). The horizontal (mean difference: 0.12 mm, P = 0.003) and vertical cup diameter (mean difference: 0.16 mm, P < 0.001) were also significantly larger in Aboriginal and Torres Strait Islander children, as were the horizontal and vertical cup-to-disc ratios (both P < 0.01). Aboriginal and Torres Strait Islander children also had a significantly thinner BMO-MRW in the superior, nasal and temporal meridians (all P < 0.001). Peripapillary RNFL thickness did not differ between groups. Conclusions: Differences exist in the ONH structure between Aboriginal and Torres Strait Islander children and non-Indigenous children which may have implications for detection and monitoring of ocular disease in this population and highlights the need to extend this research to the adult population.

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The impact of disc hemorrhage studies on our understanding of glaucoma: a systematic review 50 years after the rediscovery of disc hemorrhage

Yamamoto

2018

Jpn J Ophthalmol

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Optic disc size and progression of visual field damage in patients with normal-tension glaucoma

Cited by 5 publications

References 22 publications

Prevalence and Predictors of Ocular Complications in Obstructive Sleep Apnea Patients: A Cross-sectional Case-control Study

Prevalence and Predictors of Ocular Complications in Obstructive Sleep Apnea Patients: A Cross-sectional Case-control Study

Optical Coherence Tomography–Derived Measurements of the Optic Nerve Head Structure of Aboriginal and Torres Strait Islander Children

The impact of disc hemorrhage studies on our understanding of glaucoma: a systematic review 50 years after the rediscovery of disc hemorrhage

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