Optic disc morphometry in chronic primary open-angle glaucoma

Jonas, Jost B.; Gusek, Gabriele C.; Naumann, G. O. H.

doi:10.1007/bf02169199

Cited by 213 publications

(88 citation statements)

References 40 publications

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“…The main reason may be the pronounced interindividual variability for all optic disc variables measured in the normal population. Similar results have been obtained when optic disc variables were measured by planimetry of stereo optic disc photographs in previous studies 16. The marked interindividual variability is typical of many other quantitative biological variables, such as body height and weight, and this may be the reason why the normal group and the glaucoma group showed a pronounced overlap in the quantitative optic disc variables.…”

Section: Discussionsupporting

confidence: 87%

“…Taking into account the pattern of glaucomatous neuroretinal rim loss,21 however, with the most pronounced changes in the inferior and superior disc regions in the early stages, the sector based formula or a modification of it may be the most useful one for the early detection of glaucoma. This may hold true especially for glaucomatous eyes with focal damage of the optic nerve leading to neuroretinal notches which are typically located in the temporal inferior or temporal superior disc sectors 16. Another finding supporting the sector based formula was that it was the one having the best agreement with the other methods (Table 4).…”

Section: Discussionmentioning

confidence: 76%

“…The HRT variables were measured for the optic disc as a whole and in four separate disc sectors. The right angled superotemporal sector and the right angled inferotemporal sector were tilted 15 degrees temporal to the vertical optic disc axis 16. The temporal horizontal disc sector with 60 degrees and the nasal sector with 120 degrees covered the remaining area.…”

Section: Methodsmentioning

confidence: 97%

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Discriminant analysis models for early detection of glaucomatous optic disc changes

Iester

Jonas²,

Mardin³

et al. 2000

British Journal of Ophthalmology

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Aim-To evaluate and compare four different mathematical formulas for the early detection of morphometric optic nerve head changes in chronic open angle glaucoma. Methods-The optic nerve heads of 161 patients with perimetrically defined glaucomatous optic nerve damage and of 194 normal subjects were examined by confocal laser scanning tomography. Using four formulas of linear discriminant analysis and the optic cup shape measure as the single optic disc variable, the predictive power of each of these methods was examined to diVerentiate between the normal eyes and the glaucoma eyes. Results-The highest predictive power had an optic disc sector based formula, in particular in eyes with medium and large optic discs. This optic disc sector based formula was the one with the best agreement with the other formulas examined. It achieved a better predictability than any single optic disc variable evaluated. Conclusions-Combining quantitative optic disc variables by discriminant analysis functions, the predictive power of semiautomatic quantitative optic nerve head evaluation can be improved by providing the ophthalmologist with a diagnostic score for the detection of glaucomatous optic nerve damage. Because of the pattern of glaucomatous neuroretinal rim loss, an optic disc sector based discriminant formula may have a higher diagnostic precision than other formulas in detecting early glaucomatous damage. (Br J Ophthalmol 2000;84:464-468) Glaucomatous optic nerve damage leads to a multitude of morphological changes of the optic nerve head and to a great variety of functional deficits. The loss in function can be measured by achromatic or blue on yellow perimetry, flicker perimetry, colour vision testing, and many other psychophysical strategies. 1Most of the morphological alterations of the optic nerve head have been described semiquantitatively or qualitatively using the cup/ disc diameter ratio and qualitative variables such as the occurrence of disc haemorrhages and neuroretinal rim notches. 2Since the introduction of confocal laser scanning tomography, new technology has made possible the semiautomatic quantification of the topography optic nerve head. [3][4][5][6][7][8] Using this technique, a whole array of new quantitative variables has become available to detect early changes of the optic disc. [9][10][11][12][13][14] In an eVort to increase the predictive value of the quantitative variables in diVerentiating normal eyes from eyes with early glaucomatous damage, mathematical equations combining various morphometric variables have been proposed to increase the ability to detect early morphological changes.9 10 12-15The purpose of this investigation was to evaluate and compare four of these mathematical models (which have already been calculated and tested in previous studies on diVerent study populations in other glaucoma centres) on a new group of patients with glaucoma. Patients and methodsThe study included 161 patients with chronic open angle glaucoma with a mean age of 54.9 (SD 11.7) years (range 2...

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 76%

Section: Methodsmentioning

confidence: 97%

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Discriminant analysis models for early detection of glaucomatous optic disc changes

Iester

Jonas²,

Mardin³

et al. 2000

British Journal of Ophthalmology

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“…Papillometric evaluations of patients were based on 15° colour optic disc photographs. Criteria for glaucoma diagnosis were an open anterior chamber angle and a glaucomatous appearance of the optic nerve head including an unusually small neuroretinal rim area in relation to the optic disc size, and a larger vertical than horizontal cup-to-disc ratio 15. All individuals had clear optic media, visual acuity of 6/20 or better, and intraocular pressure (IOP) less than 23 mm Hg.…”

Section: Methodsmentioning

confidence: 99%

Objective perimetry using a four-channel multifocal VEP system: correlation with conventional perimetry and thickness of the retinal nerve fibre layer

Horn

Kaltwasser²,

Jünemann³

et al. 2011

Br J Ophthalmol

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Purpose There is evidence that multifocal visual evoked potentials (VEPs) can be used as an objective tool to detect visual field loss. The aim of this study was to correlate multifocal VEP amplitudes with standard perimetry data and retinal nerve fibre layer (RNFL) thickness. Method Multifocal VEP recordings were performed with a four-channel electrode array using 58 stimulus fields (pattern reversal dartboard). For each field, the recording from the channel with maximal signal-to-noise ratio (SNR) was retained, resulting in an SNR optimised virtual recording. Correlation with RNFL thickness, measured with spectral domain optical coherence tomography and with standard perimetry, was performed for nerve fibre bundle related areas. Results The mean amplitudes in nerve fibre related areas were smaller in glaucoma patients than in normal subjects. The differences between both groups were most significant in mid-peripheral areas. Amplitudes in these areas were significantly correlated with corresponding RNFL thickness (Spearman R¼0.76) and with standard perimetry (R¼0.71). Conclusion The multifocal VEP amplitude was correlated with perimetric visual field data and the RNFL thickness of the corresponding regions. This method of SNR optimisation is useful for extracting data from recordings and may be appropriate for objective assessment of visual function at different locations. Trial registration number This study has been registered at http://www.clinicaltrials.gov (NCT00494923).

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“…Photographs were evaluated by two masked observers (both fellowship-level trained in glaucoma), using a grading system of 0–5 based on both cupping size and morphology as described by Jonas et al 10 (see fig 3). …”

Section: Methodsmentioning

confidence: 99%

Correlation between optical coherence tomography and glaucomatous optic nerve head damage in children

El-Dairi

Holgado

Asrani

et al. 2008

British Journal of Ophthalmology

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Optic disc morphometry in chronic primary open-angle glaucoma

Cited by 213 publications

References 40 publications

Discriminant analysis models for early detection of glaucomatous optic disc changes

Discriminant analysis models for early detection of glaucomatous optic disc changes

Objective perimetry using a four-channel multifocal VEP system: correlation with conventional perimetry and thickness of the retinal nerve fibre layer

Correlation between optical coherence tomography and glaucomatous optic nerve head damage in children

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