Optic Disc Evaluation by Optical Coherence Tomography in Nonarteritic Anterior Ischemic Optic Neuropathy

Contreras, Inés; Rebolleda, Gema; Noval, Susana; Muñoz‐Negrete, Francisco J.

doi:10.1167/iovs.07-0171

Cited by 88 publications

(63 citation statements)

References 37 publications

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“…The reduction in cup size appears to represent an anatomical risk factor for the development of NAION. There have been conflicting results regarding the reduction of total disc area in patients with NAION, with some studies showing a decrease in disc area size [79][80][81]. Variability in these observations may reflect differences in the technology used to measure disc area, with some studies using OCT technology while others used the HRT.…”

Section: Non-arteritic Anterior Ischemic Optic Neuropathymentioning

confidence: 99%

“…In one study of patients with NAION, arteritic anterior ischemic optic neuropathy (AAION) and open angle glaucoma, patients with open angle glaucoma had greater cup size and thinning of the neuroretinal rim than those with NAION and AAION. In comparing patients with AAION and NAION and controlling for the degree of visual field loss, patients with AAION had greater cup volume [80,81].…”

Section: Non-arteritic Anterior Ischemic Optic Neuropathymentioning

confidence: 99%

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Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

et al. 2011

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Summary: Axonal and neuronal degeneration are important features of multiple sclerosis (MS) and other neurologic disorders that affect the anterior visual pathway. Optical coherence tomography (OCT) is a non-invasive technique that allows imaging of the retinal nerve fiber layer (RNFL), a structure which is principally composed of ganglion cell axons that form the optic nerves, chiasm, and optic tracts. Since retinal axons are nonmyelinated until they penetrate the lamina cribrosa, the RNFL is an ideal structure (no other central nervous system tract has this unique arrangement) for visualizing the processes of neurodegeneration, neuroprotection and, potentially, even neuro-repair. OCT is capable of providing high-resolution reconstructions of retinal anatomy in a rapid and reproducible fashion and permits objective analysis of the RNFL (axons) as well as ganglion cells and other neurons in the macula. In a systematic OCT examination of multiple sclerosis (MS) patients, RNFL thickness and macular volumes are reduced when compared to disease-free controls.Conspicuously, these changes, which signify disorganization of retinal structural architecture, occur over time even in the absence of a history of acute demyelinating optic neuritis. RNFL axonal loss in MS is most severe in those eyes with a corresponding reduction in low-contrast letter acuity (a sensitive vision test involving the perception of gray letters on a white background) and in those patients who exhibit the greatest magnitude of brain atrophy, as measured by validated magnetic resonance imaging techniques. These unique structure-function correlations make the anterior visual pathway an ideal model for investigating the effects of standard and novel therapies that target axonal and neuronal degeneration. We provide an overview of the physics of OCT, its unique properties as a non-invasive imaging technique, and its potential applications toward understanding mechanisms of brain tissue injury in MS, other optic neuropathies, and neurologic disorders.

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Section: Non-arteritic Anterior Ischemic Optic Neuropathymentioning

confidence: 99%

Section: Non-arteritic Anterior Ischemic Optic Neuropathymentioning

confidence: 99%

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

et al. 2011

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“…Previous studies have demonstrated that OCT is a useful tool for diagnosing and following up several conditions that cause anterior optic pathway damage, including inflammatory and demyelinating diseases [8][9][10][11][12][22][23][24] . OCT has also been proposed as a biomarker for MS and as an aid for monitoring disease progression and treatment response 23,25,26 .…”

Section: A Total Of 26 Eyes From 26 Patients With Idiopathic Letm Undmentioning

confidence: 99%

“…The prognosis is worse for NMO than for MS and, since the treatment is currently different for these two conditions, early distinction of MS from NMOrelated disorders is of great importance 6,7 . Optical coherence tomography (OCT) is a noninvasive technique that can detect retinal nerve fiber layer (RNFL) thickness abnormalities in different types of anterior optic pathway diseases [8][9][10][11][12][13][14] . Axonal loss can also be estimated by measuring the decrease in macular thickness and volume caused by loss of retinal ganglion cell bodies that is induced by permanent axonal damage 9 .…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography evaluation of retinal nerve fiber layer in longitudinally extensive transverse myelitis

Moura

Fernandes

Apóstolos‐Pereira

et al. 2011

Arq. Neuro-Psiquiatr.

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Objective: To compare optical coherence tomography (OCT) measurements on the retinal nerve fiber layer (RNFL) of healthy controls and patients with longitudinally extensive transverse myelitis (LETM) without previous optic neuritis. Method: Twenty-six eyes from 26 patients with LETM and 26 control eyes were subjected to automated perimetry and OCT for comparison of RNFL measurements. Results: The mean deviation values from perimetry were significantly lower in patients with LETM than in controls (p<0.0001). RNFL measurements in the nasal quadrant and in the 3-o'clock segment were significantly smaller in LETM eyes than in controls. (p=0.04 and p=0.006, respectively). No significantly differences in other RNFL measurements were found. Conclusion: Patients with LETM may present localized RNFL loss, particularly on the nasal side of the optic disc, associated with slight visual field defects, even in the absence of previous episodes of optic neuritis. These findings emphasize the fact that patients with LETM may experience attacks of subclinical optic nerve damage. Key words: tomography, optical coherence, transverse myelitis, neuromyelitis optica, multiple sclerosis.Avaliação da camada de fibras nervosas da retina na mielite transversal longitudi nalmente extensa usando tomografia de coerência óptica RESUMO Objetivo: Comparar as medidas da camada de fibras nervosas da retina (CFNR) usando a tomografia de coerência óptica (TCO) em indivíduos normais e pacientes com mielite transversal longitudinalmente extensa (MTLE) sem episódio prévio de neurite óptica. Método: Vinte e seis olhos de 26 pacientes com MTLE e 26 olhos normais foram submetidos à campimetria computadorizada e TCO para comparação das medidas da CFNR. Resultados: Valores do parâmetro desvio médio da campimetria computadorizada foram significativamente menores nos pacientes com MTLE do que nos controles (p<0,001). Medidas da CFNR no quadrante nasal e no segmento 3 horas foram significativamente menores nos olhos dos pacientes com MTLE do que nos olhos normais (p=0,04 e p=0,006, respectivamente). Não foi encontrada diferença significante nas outras medidas da CFNR avaliadas. Conclusão: Pacientes com MTLE podem apresentar perda localizada da CFNR, particularmente na região nasal do disco óptico, associada a defeitos discretos de campo visual, mesmo na ausência de episódio prévio de neurite óptica. Estes achados sugerem que pacientes com MTLE podem apresentar acometimento subclínico do nervo óptico. Palavras-chave: tomografia de coerência óptica, mielite transversa, neuromielite óptica, esclerose múltipla.

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“…Apart from vascular factors, there also are structural and mechanical factors that may contribute to ONH damage. However, NAION is considered as a multifactorial disorder, although numerous studies revealed that the crowded disc and its excavation were more important risk factors than ischemia [11][12][13][14][15] . Unlike POAG, NAION is characterized by optic disc swelling with resolution over weeks, visual fi eld defects, morphological alteration, pallor of the optic disc, and relatively preserved neuroretinal rim.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Optic Nerve Head Morphology in Patients with Primary Open Angle Glaucoma and Non-Arteritic Anterior Ischemic Optic Neuropathy

Jurišić

Lauš

Sesar

et al. 2017

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SUMMARY -Th e aim of this study was to assess damage to retinal ganglion cells (RGC) and morphology of the optic nerve head (ONH) in patients with primary open angle glaucoma (POAG) and non-arteritic anterior ischemic optic neuropathy (NAION). Th e study included three groups of patients, as follows: 40 eyes with POAG, 40 eyes with NAION and 40 eyes with refraction anomaly. All patients underwent standard automated perimetry and analysis of ONH topography by using confocal scanning laser ophthalmoscopy (CSLO)-HRT II. Visual fi eld defects such as decreased retinal sensitivity prevailed in the eyes with POAG, whereas in the eyes with NAION they were mostly manifested as concentrically narrowed visual fi eld and quadrant excesses. Topographic ONH alterations, examined by HRT II, showed the same number of sectors to be aff ected in the eyes with POAG and NAION. A larger number of sectors in the upper part of ONH were aff ected in the eyes with NAION. Optic disc morphology diff ered signifi cantly between the eyes with POAG and NAION by a higher rate of neuroretinal rim thinning and higher mean cup depth in the POAG group.

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Optic Disc Evaluation by Optical Coherence Tomography in Nonarteritic Anterior Ischemic Optic Neuropathy

Cited by 88 publications

References 37 publications

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

Optical coherence tomography evaluation of retinal nerve fiber layer in longitudinally extensive transverse myelitis

Comparison of Optic Nerve Head Morphology in Patients with Primary Open Angle Glaucoma and Non-Arteritic Anterior Ischemic Optic Neuropathy

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