Optic disc area and correlation with central corneal thickness, corneal hysteresis and ocular pulse amplitude in glaucoma patients and controls

Insull, Elizabeth A.; Nicholas, Simon; Ang, Ghee Soon; Poostchi, Ali; Chan, Kenneth; Wells, Anthony P

doi:10.1111/j.1442-9071.2010.02373.x

Cited by 18 publications

(15 citation statements)

References 24 publications

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“…Research studies have consistently reported that individuals with glaucoma have significantly lower CH measurements than healthy controls. 44,46 However, contradictory findings have been reported for CH measurements in individuals with keratoconus. Some studies have reported that mean CH measurements are significantly lower in individuals with keratoconus than normal individuals.…”

Section: Discussionmentioning

confidence: 79%

“…27 The Ocular Hypertension Treatment Study (OHTS) noted that thinner CCT measurements are a risk factor for the development of primary open-angle glaucoma. 43 Moreover, previous studies have reported that eyes with thinner CCT measurements have larger 44,45 and deeper optic cups. Corneal hysteresis describes the viscoelastic characteristic of the cornea 4 and has been shown to vary in eyes with different ocular diseases.…”

Section: Discussionmentioning

confidence: 99%

“…There is no correlation between CH and RNFL or GCC thickness. 46,49 Moreover, Insull et al 44 suggested that CH does not affect the optic disc size as it is not related to the optic disc area. It is possible that the lack of association between CH and RNFL, GCC as well as optic disc size may account for the similar RNFL and GCC thicknesses noted between the two groups in this study.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Retinal nerve fibre layer and ganglion cell complex thickness in patients with keratoconus

Cuppusamy

Makhanya

Methula

et al. 2018

Afr. vis. eye health

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Background: Keratoconus, a corneal ectasia, is associated with corneal thinning and altered optical media. Consequently, assessment of the visual field, optic nerve head and intraocular pressure measurements may be challenging in patients with keratoconus. Few studies have investigated posterior segment variables including the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thickness in patients with keratoconus.Aim: To investigate RNFL and GCC thickness in patients with keratoconus.Methods: A comparative quantitative research design was used. The sample consisted of 56 participants (28 with mild, moderate or severe keratoconus, and 28 controls) who accessed the optometry clinic at the University of KwaZulu-Natal. There was an equal distribution of male (n = 14) and female (n = 14) participants in the keratoconus and control groups. Most participants were black (n = 34) or Indian (n = 18). Corneal power and refractive error were assessed with the Oculus Keratograph and subjective refraction respectively. The iVue-100 optical coherence topography device was used to measure RNFL and GCC thickness. Data were analysed by descriptive and inferential statistics.Results: The mean global RNFL thickness was slightly higher in the control group than the keratoconus group for the right (106 µm vs. 99 µm) and left (103 µm vs. 98 µm) eyes but these differences were not significant (p ≥ 0.057). For all RNFL quadrants, slightly lower mean RNFL measurements were found in the keratoconus group. The mean GCC thicknesses were marginally higher (3 µm – 6 µm) in the control group.Conclusion: The RNFL and GCC thickness differences between patients with keratoconus and controls are not clinically significant. Therefore, abnormally reduced RNFL and GCC thickness measurements in patients with keratoconus warrant further investigation for other pathologies specifically glaucoma.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Retinal nerve fibre layer and ganglion cell complex thickness in patients with keratoconus

Cuppusamy

Makhanya

Methula

et al. 2018

Afr. vis. eye health

View full text Add to dashboard Cite

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“…This is consistent with the long-held belief that damage to components of the aqueous outflow pathways by reactive oxygen species (ROS) contributes to elevated IOP, a common feature observed in POAG (Siegfried et al, 2015). In other studies a correlation between CCT, optic nerve head topography, and visual field damage was found (Cankaya et al, 2008; Coman et al, 2014; Iester et al, 2012; Insull et al, 2010; Kaushik et al, 2006; Mokbel and Ghanem, 2010; Pakravan et al, 2007; Papadia et al, 2007; Saenz-Frances et al, 2015; Sullivan-Mee et al, 2005). The relationship between POAG risk and CCT is complex and poorly understood.…”

Section: Genetic Analyses Of Poag-associated Traits (Endophenotypes)mentioning

confidence: 73%

Major review: Molecular genetics of primary open-angle glaucoma

Liu

Allingham

2017

Experimental Eye Research

123

106

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Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), the most common type, is a complex inherited disorder that is characterized by progressive retinal ganglion cell death, optic nerve head excavation, and visual field loss. The discovery of a large, and growing, number of genetic and chromosomal loci has been shown to contribute to POAG risk, which carry implications for disease pathogenesis. Differential gene expression analyses in glaucoma-affected tissues as well as animal models of POAG are enhancing our mechanistic understanding in this common, blinding disorder. In this review we summarize recent developments in POAG genetics and molecular genetics research.

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“…A previous study reported a relationship between cornea and optic disc dimensions and that the larger the cornea, the larger the optic disc (10) . Another study found a reverse relationship between CCT and the optic nerve area in primary open angle glaucoma patients and this relationship was shown to result in larger optic nerve areas with thinner corneas (11) . TDS is a congenital optic disc anomaly that affects the anterior and posterior segments of the eye.…”

Section: Discussionmentioning

confidence: 99%

Corneal structure in tilted disc syndrome

Gündüz¹,

Polat²,

Cumurcu³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Purpose: To evaluate the central corneal thickness (CCT), corneal volume (CV), and anterior and posterior corneal surfaces using the Scheimpflug imaging system in patients diagnosed with tilted disc syndrome (TDS). Methods: The study group (Group 1) and the control group (Group 2) comprised 35 eyes of 35 age-, sex-, and refraction-matched cases. All cases underwent a full ophthalmic examination that included cycloplegic refraction, axial ocular length measurement, and Scheimpflug imaging. Results: The mean age was 34.68 ± 15.48 years in Group 1 and 34.11 ± 12.01 years in Group 2 (p=0.864). The gender distribution was 18 males and 17 females in Group 1 and 16 males and 19 females in Group 2 (p=0.618). All subjects were Caucasian. The spherical equivalent was 3.62 ± 1.75 D in Group 1 and 3.69 ± 1.51 D in Group 2 (p=0.850). There was no significant difference in age, sex, race, or spherical equivalent between groups. There was no significant difference in mean keratometric value and CV3 (the CV in the central 3 mm) between groups (p=0.232 and 0.172, respectively). There were statistically significant differences in CCT, CV5, and CV7 (CV in the central 5 and 7 mm 3 , respectively) and total CV between groups (p=0.008, 0.003, 0.023, and 0.019, respectively). The values of all parameters were lower in the study group than in the control group. There was also a statistically significant difference in the anterior elevation parameters of the cornea between groups (p<0.05). The mean values of Group 1 were higher than those of Group 2. There were statistically significant differences in the two parameters referring to the posterior elevation of the cornea between the two groups (p<0.05). Conclusion:The results of this study showed that eyes with TDS have thinner CCT, lower CV, and different anterior corneal curvature than normal eyes. (p=0,232, p=0,172, respectivamente). Houve diferença estatisticamente significativa entre os dois grupos para CCT, CV5, CV7 (volume de córnea na região central 5 e 7 mm, respectivamente) e CV total (p=0,008, p=0,003, p=0,023 e p=0,019, respectivamente Keywords

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Optic disc area and correlation with central corneal thickness, corneal hysteresis and ocular pulse amplitude in glaucoma patients and controls

Abstract: There was an inverse relationship between CCT and optic disc area in this study group. No association was found between optic disc area and OPA or CH.

Cited by 18 publications

References 24 publications

Retinal nerve fibre layer and ganglion cell complex thickness in patients with keratoconus

Retinal nerve fibre layer and ganglion cell complex thickness in patients with keratoconus

Major review: Molecular genetics of primary open-angle glaucoma

Corneal structure in tilted disc syndrome

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