Optic ataxia is not only ‘optic’: Impaired spatial integration of proprioceptive information

Blangero, Annabelle; Ota, Hisaaki; Delporte, Ludovic; Revol, Patrice; Vindras, Philippe; Rode, Gilles; Boisson, Dominique; Vighetto, Alain; Rossetti, Yves; Pisella, Laure

doi:10.1016/j.neuroimage.2007.03.039

Cited by 76 publications

(62 citation statements)

References 25 publications

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“…Third, our hand/visual hemifield specificity is also consistent with neuronal activity found in monkeys (Chang et al, 2008) and BOLD activation in the mIPS and AG regions of human PPC (Medendorp et al, 2003(Medendorp et al, , 2005Beurze et al, 2007). Finally, our results are consistent with hand-and visual hemifield-specific deficits in optic ataxia (OA) (Perenin and Vighetto, 1988; Rossetti et al, 2003;Blangero et al, 2007Blangero et al, , 2008Khan et al, 2007;Pisella et al, 2009) and directional motor impairments in neglect (Mattingley et al, 1998;Husain et al, 2000).…”

Section: Hemispheric Asymmetry In the Rtms Effect On Saccadessupporting

confidence: 88%

Specificity of Human Parietal Saccade and Reach Regions during Transcranial Magnetic Stimulation

Vesia

Prime²,

Yan³

et al. 2010

J. Neurosci.

142

159

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Single-unit recordings in macaque monkeys have identified effector-specific regions in posterior parietal cortex (PPC), but functional neuroimaging in the human has yielded controversial results. Here we used on-line repetitive transcranial magnetic stimulation (rTMS) to determine saccade and reach specificity in human PPC. A short train of three TMS pulses (separated by an interval of 100 ms) was delivered to superior parieto-occipital cortex (SPOC), a region over the midposterior intraparietal sulcus (mIPS), and a site close to caudal IPS situated over the angular gyrus (AG) during a brief memory interval while subjects planned either a saccade or reach with the left or right hand. Behavioral measures then were compared to controls without rTMS. Stimulation of mIPS and AG produced similar patterns: increased end-point variability for reaches and decreased saccade accuracy for contralateral targets. In contrast, stimulation of SPOC deviated reach end points toward visual fixation and had no effect on saccades. Contralateral-limb specificity was highest for AG and lowest for SPOC. Visual feedback of the hand negated rTMS-induced disruptions of the reach plan for mIPS and AG, but not SPOC. These results suggest that human SPOC is specialized for encoding retinally peripheral reach goals, whereas more anterior-lateral regions (mIPS and AG) along the IPS possess overlapping maps for saccade and reach planning and are more closely involved in motor details (i.e., planning the reach vector for a specific hand). This work provides the first causal evidence for functional specificity of these parietal regions in healthy humans.

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Section: Hemispheric Asymmetry In the Rtms Effect On Saccadessupporting

confidence: 88%

Specificity of Human Parietal Saccade and Reach Regions during Transcranial Magnetic Stimulation

Vesia

Prime²,

Yan³

et al. 2010

J. Neurosci.

142

159

View full text Add to dashboard Cite

show abstract

“…In fact, the basic premise of the present paradigm is based on the interpretation by Jackson et al (2009) of the deficits in nonfoveal OA patients. In OA, the disorder of visually guided reaching movements cannot be attributed to a basic motor or sensory deficit (Bálint 1909;Perenin and Vighetto 1988;Rizzo and Vecera 2002), but seems a higher-level impairment in spatial integration of information from both vision and proprioception (Blangero et al 2007(Blangero et al , 2009Khan et al 2005a,b;Pisella et al 2009). According to Jackson et al (2009), these deficits result from an impaired ability to simultaneously represent multiple spatial locations that must be directly compared with one another.…”

Section: Relation To Previous Workmentioning

confidence: 99%

“…More recent findings, however, have challenged this notion by providing evidence for a hand-target comparison in gaze-centered coordinates (Beurze et al 2006;Blangero et al 2007Blangero et al , 2010; Buneo et al 2002;Pisella et al 2009). …”

Section: Introductionmentioning

confidence: 99%

“…Buneo et al (2002) showed that position of the hand relative to gaze modulated the neuronal activity in area 5 of the posterior parietal cortex (PPC), whereas Pesaran et al (2006) discovered that reach-related activity in neurons in the dorsal premotor cortex depends on hand, eye, and target positions. Finally, unilateral and bilateral optic ataxia patients with damage in the PPC show reach deficits that reflect the use of gaze-centered coordinates (Blangero et al 2007(Blangero et al , 2009(Blangero et al , 2010Coslett 1997, 1998;Jackson et al 2009;Khan et al 2005a,b;Pisella et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Reference Frames for Reach Planning in Human Parietofrontal Cortex

Beurze

Toni

Pisella

et al. 2010

Journal of Neurophysiology

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To plan a reaching movement, the brain must integrate information about the spatial goal of the reach with positional information about the selected hand. Recent monkey neurophysiological evidence suggests that a mixture of reference frames is involved in this process. Here, using 3T functional magnetic resonance imaging (fMRI), we tested the role of gaze-centered and bodycentered reference frames in reach planning in the human brain. Fourteen human subjects planned and executed arm movements to memorized visual targets, while hand starting position and gaze direction were monitored and varied on a trial-by-trial basis. We further introduced a variable delay between target presentation and movement onset to dissociate cerebral preparatory activity from stimulusand movement-related responses. By varying the position of the target and hand relative to the gaze line, we distinguished cerebral responses that increased for those movements requiring the integration of peripheral target and hand positions in a gaze-centered frame. Posterior parietal and dorsal premotor areas showed such gaze-centered integration effects. In regions closer to the primary motor cortex, bodycentered hand position effects were found. These results suggest that, in humans, spatially contiguous neuronal populations operate in different frames of reference, supporting sensorimotor transformations according to gaze-centered or body-centered coordinates. The former appears suited for calculating a difference vector between target and hand location, whereas the latter may be related to the implementation of a joint-based motor command.

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“…Optic ataxia, from lesions centered on the superior parietal lobule (SPL) (for review, see Battaglia-Mayer and Caminiti, 2002;Caminiti et al, 2005), prevents accurate performance of hand reaches to visual targets. These patients exhibit a specific deficit in localizing visual targets with respect to their body (Holmes and Horrax, 1919;Rondot et al, 1977;Danckert et al, 2009) as well as in the integration of visual and proprioceptive information (Blangero et al, 2007(Blangero et al, , 2008Khan et al, 2007) about hand position.…”

Section: Introductionmentioning

confidence: 99%

Reaching in Depth: Hand Position Dominates over Binocular Eye Position in the Rostral Superior Parietal Lobule

et al. 2009

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Neural activity was recorded in area PE (dorsorostral part of Brodmann's area 5) of the posterior parietal cortex while monkeys performed arm reaching toward memorized targets located at different distances from the body. For any given distance, arm movements were performed while the animal kept binocular eye fixation constant. Under these conditions, the activity of a large proportion (36%) of neurons was modulated by reach distance during the memory period. By varying binocular eye position (vergence angle) and initial hand position, we found that the reaching-related activity of most neurons (61%) was influenced by changing the starting position of the hand, whereas that of a smaller, although substantial, population (13%) was influenced by changes of binocular eye position (i.e., by the angle of vergence). Furthermore, the modulation of the neural activity was better explained expressing the reach movement end-point, corresponding to the memorized target location, in terms of distance from the initial hand position, rather than from the body. These results suggest that the activity of neurons in area PE combines information about eye and hand position to encode target distance for reaching in depth predominantly in hand coordinates. This encoding mechanism is consistent with the position of PE in the functional gradient that characterizes the parieto-frontal network underlying reaching.

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Optic ataxia is not only ‘optic’: Impaired spatial integration of proprioceptive information

Cited by 76 publications

References 25 publications

Specificity of Human Parietal Saccade and Reach Regions during Transcranial Magnetic Stimulation

Specificity of Human Parietal Saccade and Reach Regions during Transcranial Magnetic Stimulation

Reference Frames for Reach Planning in Human Parietofrontal Cortex

Reaching in Depth: Hand Position Dominates over Binocular Eye Position in the Rostral Superior Parietal Lobule

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