Optic ataxia errors depend on remapped, not viewed, target location

Khan, Aarlenne Z.; Pisella, Laure; Vighetto, Alain; Cotton, François; Luauté, Jacques; Boisson, Dominique; Salemme, Roméo; Crawford, J. Douglas; Rossetti, Yves

doi:10.1038/nn1425

Cited by 115 publications

(84 citation statements)

References 12 publications

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“…Likewise, establishing correlations between hand and eye motor commands would allow the specification of hand motor commands in gazecentered coordinates Engel et al, 2002;Crawford et al, 2004). In visually guided reaching, there is evidence that both targets and the hand are represented in gazecentered frames of reference in various brain regions (Mushiake et al, 1997;Batista et al, 1999;Stuphorn et al, 2000;Buneo et al, 2002;Medendorp et al, 2003;Khan et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Eye–Hand Coordination during Learning of a Novel Visuomotor Task

Sailer¹,

Flanagan²,

Johansson³

2005

J. Neurosci.

243

227

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We investigated how gaze behavior and eye-hand coordination change when subjects learned a challenging visuomotor task that required acquisition of a novel mapping between bimanual actions and their visual sensory consequences. By applying isometric forces and torques to a rigid tool held freely between the two hands, subjects learned to control a cursor on a computer screen to hit successively displayed targets as quickly as possible. The learning occurred in stages that could be distinguished by changes in performance (targethit rate) as well as by gaze behavior and eye-hand coordination. In a first exploratory stage, the hit rate was consistently low, the cursor position varied widely, and gaze typically pursued the cursor. In a second skill acquisition stage, the hit rate improved rapidly, and gaze fixations began to mark predictively desired cursor positions, indicating that subjects started to program spatially congruent eye and hand motor commands. In a third skill refinement stage, performance continued to improve gradually, and gaze shifted directly toward the target. We suggest that during the exploratory stage, the learner attempts to establish basic mapping rules between manual actions and eye-movement commands. In this process, subjects may establish correlations between hand motor commands and their visual sensory consequences, primarily in fovea-anchored, gaze-centered coordinates, and correlations between recent hand motor commands and eye motor commands. The established mapping rules are then implemented and refined in the skill acquisition and refinement stages.

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Section: Discussionmentioning

confidence: 99%

Eye–Hand Coordination during Learning of a Novel Visuomotor Task

Sailer¹,

Flanagan²,

Johansson³

2005

J. Neurosci.

243

227

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“…It was argued that a more appropriate characterization of optic ataxia should emphasize the distinction between central and peripheral vision rather than the distinction between perception and action 7 . Other studies have shown that optic ataxia affects only specific aspects of visuomotor behaviour 14 and egocentric coding 15 . It thus appears that neither the perception/action nor the allocentric/egocentric distinction can provide a satisfactory account of this complex disorder.…”

Section: An Allocentric Rather Than Perceptual Deficit In Patient Dfmentioning

confidence: 96%

An allocentric rather than perceptual deficit in patient D.F.

2006

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“…Moreover, these patients presenting with OA without neglect, resulting from dorsal PPC lesions (i.e. lesions of the SPL and the IPS), have shown preserved visual remapping in the context of a trans-saccadic pointing task ( [45,46]; figure 4a). As a consequence, the dorsal PPC region, damaged in OA patients and involved in visuo-manual transformations, cannot be considered to be a region crucially involved in visual remapping.…”

Section: Introductionmentioning

confidence: 99%

“…Then, the visual stimulus extinguishes and the subject is requested to produce a saccade that crosses the stimulus location and brings its location into the opposite visual space (across-hemifield visual remapping conditions). Behaviour [46] and brain activity [47][48][49] have demonstrated that, consequent to the saccade, the representation of the (extinguished) visual stimulus was transferred to the ipsilateral hemisphere. Neuroimaging studies have shown this interhemispheric transfer between homologous cortical regions, at the level of the posterior parietal cortices (PPC; [48,49]; figure 2a) or the occipital striate and extrastriate cortices [47].…”

Section: Introductionmentioning

confidence: 99%

“…At the level of the PPC, interhemispheric transfer may rather reflect the visuo-motor updating of the saccadic or pointing goals, i.e. the visuomotor preparation of a movement in the opposite direction when the saccade brings the next visual goal location into the opposite oculocentric space [45,46,49] (figure 4a,b). However, this hypothesis is more uncertain since the conflict between 'attentional' (visuo-spatial) and 'intentional' (visuo-motor) views of the PPC remains unresolved ( [50] and [51], respectively).…”

Section: Introductionmentioning

confidence: 99%

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Right-hemispheric dominance for visual remapping in humans

Pisella

Alahyane

Blangero

et al. 2011

Phil. Trans. R. Soc. B

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We review evidence showing a right-hemispheric dominance for visuo-spatial processing and representation in humans. Accordingly, visual disorganization symptoms (intuitively related to remapping impairments) are observed in both neglect and constructional apraxia. More specifically, we review findings from the intervening saccade paradigm in humans-and present additional original data-which suggest a specific role of the asymmetrical network at the temporo-parietal junction (TPJ) in the right hemisphere in visual remapping: following damage to the right dorsal posterior parietal cortex (PPC) as well as part of the corpus callosum connecting the PPC to the frontal lobes, patient OK in a double-step saccadic task exhibited an impairment when the second saccade had to be directed rightward. This singular and lateralized deficit cannot result solely from the patient's cortical lesion and, therefore, we propose that it is due to his callosal lesion that may specifically interrupt the interhemispheric transfer of information necessary to execute accurate rightward saccades towards a remapped target location. This suggests a specialized right-hemispheric network for visuo-spatial remapping that subsequently transfers target location information to downstream planning regions, which are symmetrically organized.

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Optic ataxia errors depend on remapped, not viewed, target location

Cited by 115 publications

References 12 publications

Eye–Hand Coordination during Learning of a Novel Visuomotor Task

Eye–Hand Coordination during Learning of a Novel Visuomotor Task

An allocentric rather than perceptual deficit in patient D.F.

Right-hemispheric dominance for visual remapping in humans

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