Optic and Peripheral Neuritis

Abstract

Chloramphenicol is one of the most valuable antibiotics available to the physician,1 although in rare instances it may cause severe hematopoietic reactions.2 It is the purpose of this paper to emphasize another apparent severe toxic reaction\p=m-\theoccurrence of optic and peripheral neuritis. Report of a CaseThe patient was a 20-year-old man who had been in good health until Oct. 21, 1957, when he was treated with penicillin for a "flu-like" syndrome. Three days later genitourinary symptoms occurred; he became systemically ill and was hospitalized. Physical examination at that time showed only costovertebral angle tenderness. He had marked pyuria, and his chest roentgenogram showed a small infiltrate in the upper lobe of his left lung. He was treated with chlortetracycline and his genitourinary symptoms subsided. On Nov. 7, pain developed in his left shoulder, but roentgenograms were normal.

Melioidosis in Mexico, Central America, and the Caribbean

“…It was reported that before the chronic phase of the disease, the patient had suffered from an acute pneumonic phase. A second case of melioidosis, which was probably acquired in Panama, was reported in 1957 [ 20 , 21 ]. The patient was a 20-year-old male who was treated for ‘flu-like syndrome’.…”

“…He had pyuria, and a chest roentgenogram showed a small infiltrate in the upper lobe of the left lung. After one month, he developed an acute septic arthritis of the shoulder joint; pus was removed, and Pseudomonas pseudomallei was isolated in culture [ 20 ]. However, in the two aforementioned cases, the cultures were not available for further studies, and could not be considered as verified cases of melioidosis.…”

Subacute neuronopathy in a young man: a possible association with tetracycline treatment

“…penicillin or a semisynthetic derivate, 1 chloramphenicol, 2 and metronidazole. 3 Nitrofurantoin treatment has caused sensory-motor neuropathy 4 and dapsone treatment has caused motor neuropathy.…”