Opsonophagocytosis versus Complement Bactericidal Killing as Effectors following Neisseria meningitidis Group C Vaccination

Abstract

PMN did not increase post-vaccination bacterial killing, suggesting that antibody complement-mediated killing, and not opsonophagocytosis, is the main immune effector of the vaccine protection against N. meningitidis.

Spectrum and Management of Complement Immunodeficiencies (Excluding Hereditary Angioedema) Across Europe

“…The use of antibiotics as Numbers for each parameter are percentages or median (inter-quartile range). P values were calculated using Chi-square statistic well as booster vaccination is in keeping with previous studies, which have shown that meningococcal vaccination reduces but does not eliminate the risk of meningococcal disease [30] as complement-dependent bacterocidal activity is more important than complement-independent opsonophagocytosis in killing Neisseria meningitidis [31].…”

Serologic correlates of protection for evaluating the response to meningococcal vaccines

“…The OPA can be semi-automated and use beads coated with capsular polysaccharide and can also be multiplexed to analyze four serogroups in the one assay [64]. A recent study has suggested that SBA is the main immune effector of the vaccine protection against N. meningitidis rather than opsonophagocytosis following serogroup C vaccination [68]. Furthermore, there are issues of standardization between laboratories, particularly regarding the use of cultured cell lines or freshly obtained PMN cells.…”