Opsoclonus polymyoclonia syndrome

Effect of steroid and high-dose immunoglobulin therapy on opsoclonus-myoclonus syndrome occurring in neuroblastoma

“…In two patients reported by Sugie et al [8] and Fisher et al [5], a rapid improvement in OMS was obtained with HIG at doses ranging from 150 to 400 mg/kg/day for 3 or 4 consecutive days; in another case by Sheth et al [7], a complete resolution of OMS was registered with a single course of HIG (500 mg/kg/day for 5 consecutive days). On the other hand, Penzien et al [6] reported a complete failure of HIG in a patient treated with 200 mg/kg 3 times on alternate days.…”

“…The production of antibodies directly causing neurological dysfunction is a theory recently supported by Fisher et al [5], who have isolated in the cerebral spinal fluid of one patient with OMS and NB an antibody called ''anti-Hu antineural,'' which has the capacity to cross-react with neuroblastic cells. On this basis, HIG administration has been adopted as in other immunomediated neurological diseases (myasthenia, inflammatory demyelinating polyneuropathy), but results are controversial [5][6][7][8]. In two patients reported by Sugie et al [8] and Fisher et al [5], a rapid improvement in OMS was obtained with HIG at doses ranging from 150 to 400 mg/kg/day for 3 or 4 consecutive days; in another case by Sheth et al [7], a complete resolution of OMS was registered with a single course of HIG (500 mg/kg/day for 5 consecutive days).…”

“…Recently, high-dose immunoglobulin (HIG) has been administered to some patients on the basis of an immunological etiology hypothesized for this syndrome, but results are controversial [5][6][7][8].…”