Opsoclonus-Myoclonus Syndrome Associated with Scrub Typhus

Scrub typhus-associated opsoclonus: Clinical course and longitudinal outcomes in an Indian cohort

“…[ 7 18 20 ] The other two patients presented with opsomyoclonus. [ 19 21 ] Although reported individually and concomitantly in scrub typhus patients, cerebellar dysfunction and EPS have not been described previously in association with opsoclonus in this illness. [ 3 4 5 6 ] We demonstrate a clinical pattern, wherein scrub typhus-associated opsoclonus is frequently but not always accompanied by varying combinations of the above-mentioned neurological manifestations.…”

“…[ 26 ] Of the six patients with scrub typhus opsoclonus reported in literature, CSF analysis was performed in five. [ 7 19 20 21 ] The analysis was normal in two patients. [ 7 21 ] CSF albuminocytological dissociation was seen in two patients opsomyoclonus opsomyoclonus.…”

“…[ 27 ] Among the six cases of scrub typhus opsoclonus reported in literature, MR imaging of the brain was performed in five patients and was normal in all. [ 7 19 20 21 ]…”

“…The time to resolution in these patients varied between 2 days and 2 weeks. [ 7 18 19 20 21 ] Opsoclonus due to other diseases appears to be more persistent, but usually resolves with immunosuppression in adults. [ 10 ] Pediatric OMS poses a greater challenge, with nonparaneoplastic pediatric OMS requiring aggressive immunotherapy.…”

“…[ 11 12 13 14 15 16 17 ] Scrub typhus-associated opsoclonus is exceedingly rare with six reported cases in literature. [ 7 18 19 20 21 ] Given the paucity of clinical data, we set out to describe the clinical profile, laboratory features, and longitudinal outcomes, in a historical cohort of scrub typhus patients with opsoclonus.…”