Opsoclonus in salmonella infection.

Vejjajiva, Athasit; Lerdverasirikul, P

doi:10.1136/bmj.2.6097.1260

Cited by 10 publications

(4 citation statements)

References 3 publications

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“…7 Only 2 cases of opsoclonus associated with Salmonella infections have been described, both in adults. 2,3 Neuropsychiatric complications from typhoid fever, including acute confusional state, myelitis, cerebellitis, and parkinsonism have been reported. 8 Here we have described a third case of opsoclonus uniquely observed in a 6-week-old patient with salmonellosis.…”

Section: Discussionmentioning

confidence: 99%

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Opsoclonus Associated With Salmonellosis in a 6-Week-Old Infant

2013

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A 6-week-old male infant presented with 2 days of fever, emesis, and diarrhea, associated with episodic and chaotic rapid eye movements, determined to be opsoclonus. An electroencephalogram (EEG) obtained during the events was normal. He was treated empirically for meningitis, and an initial workup for neuroblastoma including urine homovanillic acid and vanillylmandelic acid levels, abdominal ultrasonography, and computed tomography (CT) of the chest, abdomen, and pelvis was negative. Stool and blood cultures were positive for Salmonella, and antibiotic regimen was adjusted appropriately. Over the next few days, his fever, emesis, and diarrhea subsided, and the opsoclonus resolved by hospital day 6. He was back to baseline by hospital day 9. Although there have been cases of parainfectious opsoclonus associated with Lyme disease, enterovirus, Streptococcus, and West Nile virus, this represents the first reported pediatric case of opsoclonus associated with salmonellosis. Only 2 such cases in adults have been reported in the literature.

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Section: Discussionmentioning

confidence: 99%

“…1 Only 2 cases of opsoclonus with Salmonella infection has been described to date, in a 21-year-old woman and 63-year-old man. 2,3 Here, we present the first pediatric case of opsoclonus associated with Salmonella infection.…”

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confidence: 99%

Opsoclonus Associated With Salmonellosis in a 6-Week-Old Infant

2013

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“…In cases of paraneoplastic OMS, small cell lung cancer, breast cancer, and ovarian cancer were most commonly encountered in adults (10), whereas more than half of these cases were associated with neuroblastoma in children (11,12). In OMS with a confirmed infectious agent, psittacosis (10,13), Mycoplasma infection (14), Salmonella infection (10,15,16), group A streptococcal infection (17), neuroborreliosis (18,19), Rickettsia infection (10), St. Louis encephalitis (10,20), coxsackievirus (10), enterovirus 71 (21), cytomegalovirus (22), Epstein-Barr virus (23), human immunodeficiency virus (24), and hepatitis C virus (25) have been described as the causative agents. Although the case of a 30-year-old woman with OMS 15 days after anti-rubella vaccination has been reported (26), seasonal influenza vaccination-related OMS has not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

Opsoclonus-Myoclonus Syndrome Following Influenza A Infection

et al. 2012

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A 60-year-old woman developed opsoclonus-myoclonus syndrome (OMS) a week after being diagnosed with influenza A infection by a rapid antigen test. She had no loss of consciousness. Opsoclonus, myoclonus, and truncal ataxia were noted. Two weeks after treatment with intravenous immunoglobulin and corticosteroids, her opsoclonus, myoclonus, and truncal ataxia disappeared. No malignant tumors were detected during the 3-year follow-up period. There has been no previous report of postinfectious OMS following confirmed influenza A infection. OMS without a loss of consciousness has been reported to be statistically less common in cases of non-paraneoplastic OMS. This finding was consistent with the present patient's clinical manifestations.

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“…The favourable response to steroid treatment also suggests possible immunological mechanisms, although an autoimmune pathogenesis has yet to be proven. The brainstem has been implicated (5,18) and several clinical settings have been associated with isolated opsoclonus but this could be an entity distinct from OPM (1,16,32,33). Encephalitic cases have shown mild lymphocytic cuffing in the brainstem, diencephalon or basal ganglia (5,37).…”

Section: Introductionmentioning

confidence: 99%

Eye Movements in Children with Opsoclonus-Polymyoclonus

Shawkat

Harris²,

Wilson³

et al. 1993

Neuropediatrics

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The anatomical localisation of the abnormality underlying opsoclonus-polymyoclonus-the "Dancing Eye Syndrome"-is uncertain and both the brainstem and cerebellum have been implicated. We used electrooculographic recordings to assess the eye movements in five children with this syndrome. Overshoot dysmetria was the consistent feature for the saccades of all five cases. One patient was also assessed after the main symptoms of ataxia and opsoclonus (saccadic oscillations, without an intersaccadic interval) had resolved and the saccades were found to remain hypermetric. Smooth pursuit and optokinetic nystagmus were normal, although the opsoclonus occurred throughout the recording session and were superimposed upon the normal eye movement waveforms. The vestibulo-ocular reflex was normal in four patients, but in one case, the time-constant was significantly prolonged: this has only been reported in experimental lesions of the nodulus in monkeys. The presence of saccadic overshoot dysmetria is highly suggestive of a cerebellar origin for the abnormal eye movements in these children. However, the preservation of normal smooth pursuit and the absence of gaze-paretic, rebound and downbeat nystagmus, implies the sparing of the flocculus and paraflocculus. We propose that the origin of these oculomotor deficits could be the cerebellar fastigial nuclei.

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Opsoclonus in salmonella infection.

Cited by 10 publications

References 3 publications

Opsoclonus Associated With Salmonellosis in a 6-Week-Old Infant

Opsoclonus Associated With Salmonellosis in a 6-Week-Old Infant

Opsoclonus-Myoclonus Syndrome Following Influenza A Infection

Eye Movements in Children with Opsoclonus-Polymyoclonus

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