Opposite Incidence Trends for Differentiated and Medullary Thyroid Cancer in Young Dutch Patients over a 30-Year Time Span

Lebbink, Chantal A; Broek, Medard F M van den; Kwast, A.B.G.; Derikx, Joep P. M.; Dierselhuis, Miranda P.; Kruijff, Schelto; Links, Thera P.; Trotsenburg, A S Paul van; Valk, Gerlof D.; Vriens, Menno R.; Stuart, A. A. Verrijn; Santen, Hanneke M van; Karim‐Kos, Henrike E.

doi:10.3390/cancers13205104

Cited by 9 publications

(12 citation statements)

References 33 publications

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“…However, in terms of percentage, the proportion of high-risk cases appeared to be higher in the pre-school group than that in the school-age group. Therefore, young age serves as a critical risk factor in the T stage and ATA risk level of DTC in children, which has some similarities to another large retrospective cohort study by Lebbink et al (5). Positive physical examination and ultrasonic examination should be attached of importance for the early diagnosis and treatment of DTC in pre-school children.…”

Section: Discussionmentioning

confidence: 66%

“…Symptoms in children are atypical at initial diagnosis, so thyroid cancer is often diagnosed in an advanced stage or after the peripheral invasion and distant metastases. Previous studies have confirmed that the range of tumor invasion is more extensive, as is often the case, the rate of distant metastases and locoregional relapse is higher in DTC children than adults (4,5). Fortunately, mortality after thyroidectomy in well-differentiated pediatric individuals is very low (6,7).…”

Section: Introductionmentioning

confidence: 85%

“…Compared to adolescents, the clinical manifestation of DTC in preadolescent children is more aggressive, with a higher recurrence and distant metastases rate ( 5 ). A recent study has unveiled that lymph node metastases were found in over 40% of children with DTC ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Retrospective analysis of clinical characteristics and risk factors of differentiated thyroid cancer in children

Chen

Lei²,

Wu³

et al. 2022

Front. Pediatr.

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BackgroundThe incidence rate of children with thyroid cancer has an increasing trend. This study aimed to investigate the clinical characteristics and therapeutic approaches of differentiated thyroid cancer (DTC) in Chinese children.Materials and methodsFrom January 1998 to March 2022, 52 cases undergoing surgical resection in Xinhua Hospital affiliated to Shanghai Jiao Tong University were divided by age (≤ 7 years old: n = 14 and 8–13 years old, n = 38). Treatment methods and clinical features were analyzed to evaluate prognostic factors for oncological outcomes.ResultsAmong the 52 cases, the proportion of local invasion in the pre-school group was found to be higher than that in the school-age group (p = 0.01). T stage was significantly different between the two groups (p ≤ 0.05); the proportion of T1–2 was higher in the school-age group (32 cases, 84.2%), while the proportion of T4 was higher in the pre-school group (6 cases, 42.8%) relatively. The postoperative complication rate was dramatically higher in pre-school children (p ≤ 0.05). Additionally, the total thyroidectomy rate in the non-recurrent group was slightly higher than that in the recurrent group (p ≤ 0.05). Over half of the recurrent cases had low T stage and low ATA (American Thyroid Association) risk levels at initial diagnosis (78.3 and 51.4%).ConclusionThe local invasion, tumor stage, and recurrent laryngeal nerve (RLN) injury rates of the pre-school group were higher than that of the school-age group, where young age served as a potential hazard in DTC children. Hence, surgeons should emphasize high-risk features and optimize individualized surgical procedures for DTC children.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 85%

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Retrospective analysis of clinical characteristics and risk factors of differentiated thyroid cancer in children

Chen

Lei²,

Wu³

et al. 2022

Front. Pediatr.

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“…This hypothesis is further supported by the much higher incidence of the condition in females aged 15–19 years old compared to females aged 10–14 years old. However, Lebbink et al [ 18 ] found a female predominance in differentiated TC even in prepubertal girls < 10 years old, who had not been exposed to a surge of estrogen levels yet. This finding is controversial, since the vast majority of recent works claimed that increased age results in an increasingly disproportionate number of females affected compared to their male peers, with nearly a 6:1 ratio by 15–19 years of age [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Increased trend of thyroid cancer in childhood over the last 30 years in EU countries: a call for the pediatric surgeon

et al. 2022

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Given the increasing incidence of thyroid cancer cases affecting the pediatric population in Europe, an epidemiological analysis of the available data is essential in order to update standards of care and recommend diagnostic and therapeutic strategies coherent to the new epidemiological trend. An observational study was conducted, considering the time interval 1991–2012, acquiring data collected by the International Agency for Research on Cancer (IARC) through the “Cancer Incidence in 5 continents plus” (CI5 plus) project and dividing patients into four groups of age (0–4, 5–9, 10–14, 15–19 years old). Data retrieved were compared to the latest report from Global Cancer Observatory, collected through the GLOBOCAN 2020 project, dividing patients in two groups: age 10–14, 15–19. Our findings highlighted an increasing prevalence of thyroid cancer rates in patients aged from 10 to 15 years old and from 15 to 19 years old, mainly in the female population, in Belarus (from 1991 to 2007), Cyprus, and Italy (from 2008 to 2012). Moreover, a further increase in incidence was highlighted in Italy according to data from GLOBOCAN 2020, with respect to other European countries.Conclusion: An increasing prevalence of thyroid cancer is seen in age groups 10–19. Further research is required to understand the underlying cause and concomitantly identify the most proper screening and diagnostic techniques of thyroid nodules. Indeed, this is crucial to reach optimal surgical standards and better prognosis, possibly with more conservative approaches and maybe less postoperative complications. What is Known:• Thyroid cancer is the 4th most common malignancy in children. What is New:• In the last decades, an increasing pattern has been recorded.• In the US, it has outlined breast cancers as the most common cancer in females.

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“…In the original article [ 1 ], there was a mistake in Figure 1 as published. In this figure, two years are missing (2000 and 2001).…”

mentioning

confidence: 99%

Correction: Lebbink et al. Opposite Incidence Trends for Differentiated and Medullary Thyroid Cancer in Young Dutch Patients over a 30-Year Time Span. Cancers 2021, 13, 5104

Lebbink

Broek

Kwast

et al. 2022

Cancers

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Opposite Incidence Trends for Differentiated and Medullary Thyroid Cancer in Young Dutch Patients over a 30-Year Time Span

Cited by 9 publications

References 33 publications

Retrospective analysis of clinical characteristics and risk factors of differentiated thyroid cancer in children

Retrospective analysis of clinical characteristics and risk factors of differentiated thyroid cancer in children

Increased trend of thyroid cancer in childhood over the last 30 years in EU countries: a call for the pediatric surgeon

Correction: Lebbink et al. Opposite Incidence Trends for Differentiated and Medullary Thyroid Cancer in Young Dutch Patients over a 30-Year Time Span. Cancers 2021, 13, 5104

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