Opposing effects of ageing on distal and proximal large arteries in hypertensives

Boutouyrie, P.; Laurent, S.; Bénétos, Athanase; Girerd, Xavier; Hoeks, Arnold P.G.; Safar, Michel E.

doi:10.1097/00004872-199208001-00023

Cited by 168 publications

(133 citation statements)

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“…As in prior studies, 17,18 we found regional heterogeneity in arterial stiffening with advancing age in our cohort. The marked increase in aortic stiffness with age with little change in peripheral arterial stiffness resulted in a reversal of the gradient of arterial stiffness from the youthful pattern of a compliant proximal aorta, which was evident in individuals aged Ͻ50 years, to a pattern of greater aortic stiffness in older participants.…”

Section: Discussionsupporting

confidence: 89%

“…However, prior studies have shown a similar pattern of minimal stiffening with advancing age in the legs. 17,18 We modeled wave reflections as though they arose from a single "effective" reflecting site. Actually, there are innumerable reflecting sites that produce a summated reflected wave that appears to arise from a single "effective" reflecting site (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

“…15,16 Prior studies have shown that central arterial stiffness increases to a far greater extent than peripheral arterial stiffness with advancing age. [17][18][19] As a result, aortic stiffness may equal or exceed peripheral arterial stiffness in the elderly. This reversal of the normal arterial stiffness gradient may diminish wave reflections and therefore increase transmission of pulsatile energy into the periphery and microcirculation.…”

mentioning

confidence: 99%

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Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women

et al. 2004

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Abstract-With advancing age, arterial stiffness and wave reflections increase and elevate systolic and pulse pressures. An elevated central pulse pressure is generally ascribed to increased wave reflection and portends an unfavorable prognosis. Using arterial tonometry, we evaluated central (carotid-femoral) and peripheral (carotid-brachial) pulse wave velocity, amplitudes of forward and reflected pressure waves, and augmentation index in 188 men and 333 women in the Framingham Heart Study offspring cohort who were free of clinical cardiovascular disease, hypertension, diabetes, smoking within the past 12 months, dyslipidemia, and obesity. In multivariable linear regression models, advancing age was the predominant correlate of higher carotid-femoral pulse wave velocity; other correlates were higher mean arterial pressure, heart rate, and triglycerides and walk test before tonometry (model R 2 ϭ0.512, PϽ0.001). A similar model was obtained for carotid-brachial pulse wave velocity (model R 2 ϭ0.227, PϽ0.001), although the increase with advancing age was smaller. Owing to different relations of age to central and peripheral stiffness measures, carotid-femoral pulse wave velocity was lower than carotid-brachial pulse wave velocity before age 50 years but exceeded it thereafter, leading to reversal of the normal central-to-peripheral arterial stiffness gradient. In this healthy cohort with a minimal burden of cardiovascular disease risk factors, an age-related increase in aortic stiffness, as compared with peripheral arterial stiffness, was associated with increasing forward wave amplitude and pulse pressure and reversal of the arterial stiffness gradient. This phenomenon may facilitate forward transmission of potentially deleterious pressure pulsations into the periphery.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women

et al. 2004

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“…At a young age, the aorta and proximal arteries dilate by approximately 10% with each heart beat, whereas the more distal muscular arteries dilate by only 2-3% with each heart beat. 19 Atherosclerosis and inflammation thicken the arterial wall and contribute to arterial stiffening over and beyond the mechanical stress. To differentiate natural degeneration of the arterial wall from aging from disease, Avolio et al 6 highlighted the interest of studies of arterial properties in population studies with low cholesterol and low prevalence of atherosclerosis, such as Chinese.…”

Section: Discussionmentioning

confidence: 99%

“…Of 2044 participants, 614 (30.0%; all men) were current smokers and 907 (44.4%; 240 women and 667 men) reported regular alcohol intake. In the current smokers, median tobacco use was 20 cigarettes per day (interquartile range, [15][16][17][18][19][20]. In participants reporting alcohol intake, median alcohol intake was 14 g per day (interquartile range, 6-21) among women and 38 g per day (18-69) in men.…”

Section: Characteristics Of Participantsmentioning

confidence: 99%

Age dependency of peripheral and central systolic blood pressures: cross-sectional and longitudinal observations in a Chinese population

Staessen

Sheng

et al. 2011

Hypertens Res

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Few studies have described the age-related changes in both peripheral and central systolic blood pressures (SBPs) in populations. We addressed this issue in 1066 women and 978 men, all untreated (mean age, 45.1 years; 27.2% hypertensive) and randomly selected from a Chinese population, of whom 369 and 330 underwent a repeat examination after 3.6 years (median). In cross-sectional analyses, central SBP increased more with age than peripheral SBP in women below age 50 (1.21 vs. 1.01 mm Hg per year; Po0.001) and in men below age 60 (0.73 vs. 0.48 mm Hg per year; Po0.001), whereas in older women (0.64 vs. 0.58 mm Hg per year; P¼0.27) and older men (0.45 vs. 0.44 mm Hg per year; P¼0.79), the slopes of central and peripheral SBPs on age were similar. Compared with men, women had steeper (Po0.001) age-related increases in peripheral and central SBPs. Systolic augmentation pressure increased with age, but this increase was substantially smaller (Po0.0001) for peripheral than central augmentation (women, 0.086 vs. 0.45 mm Hg per year; men, 0.083 vs. 0.39 mm Hg per year). In multivariable-adjusted regression, age contributed X89.7% of the explained variance in peripheral and central SBPs. In longitudinal analyses, the annual percentage increases from baseline to follow-up in peripheral and central SBP were similar (PX0.76) in both women (2.14% vs. 2.16 % per year) and men (1.33% vs. 1.34 % per year; P-values for sex difference p0.044). In conclusion, in younger subjects assessed cross-sectionally, the age-related increase was larger for central than peripheral SBP, whereas the corresponding cross-sectional estimates in older subjects and the longitudinal estimates in all subjects showed similar age-related increases in central and peripheral SBP.

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Cardiovascular ageing

Silva

Neves

2015

Anti‐ageing Nutrients

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Opposing effects of ageing on distal and proximal large arteries in hypertensives

Cited by 168 publications

References 0 publications

Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women

Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women

Age dependency of peripheral and central systolic blood pressures: cross-sectional and longitudinal observations in a Chinese population

Cardiovascular ageing

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