Opposing activities of brain opioid receptors in the regulation of humoral and cell-mediated immune responses in the rat

Radulović, Jelena; Janković, Branislav D.

doi:10.1016/0006-8993(94)91196-7

Cited by 30 publications

(9 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the central immunoenhancing effect of Met-enk appears to be mediated through MOR-independent DOR receptors. [53][54][55] Therefore, brain opioid receptors differentially affect humoral and cell-mediated immune responses. The effects of centrally applied Met-enk were antagonized by centrally administered QNtx, but not when this compound was administered systemically.…”

Section: Effects Of Central Opioids On Cellular and Humoral Immune Rementioning

confidence: 99%

Opioid Therapy and Immunosuppression

Vallejo

Leon‐Casasola²,

Benyamin³

2004

American Journal of Therapeutics

351

242

View full text Add to dashboard Cite

The idea that opioids modulate the immune system is not new. By the late 19th century, Cantacuzene, used morphine to suppress cellular immunity and lower the resistance of guinea pigs to bacterial infection. While exogenous opioids mediate immunosuppression, endogenous opiates exert opposite actions. Acute and chronic opioid administration is known to have inhibitory effects on humoral and cellular immune responses including antibody production, natural killer cell activity, cytokine expression, and phagocytic activity. Opiates behave like cytokines, modulating the immune response by interaction with their receptors in the central nervous system and in the periphery. Potential mechanisms by which central opiates modulate peripheral immune functions may involve both the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. The presence of opioid receptors outside the central nervous system is increasingly recognized. Those receptors have been identified not only in peripheral nerves but also in immune inflammatory cells. The immunosuppression mediated by opiates may explain the increased incidence of infection in heroin addicts. Opiates may also promote immunodeficiency virus infection by decreasing the secretion of alpha and beta chemokines (important inhibitory cytokines for the expression of HIV) and at the same time increasing the expression of chemoreceptors CCR5 and CCR3, coreceptors for the virus. The fact that peripheral immunosupression is mediated at least in part by opioid receptors located in the central nervous system and that intrathecally administered opioids do not exert the same immunosuppressive effects may have important clinical implications for those patients receiving long-term opioid therapy for malignant and nonmalignant pain.

show abstract

Section: Effects Of Central Opioids On Cellular and Humoral Immune Rementioning

confidence: 99%

Opioid Therapy and Immunosuppression

Vallejo

Leon‐Casasola²,

Benyamin³

2004

American Journal of Therapeutics

351

242

View full text Add to dashboard Cite

show abstract

“…Furthermore, the same cells can express opioid receptors creating a bidirectional system, whereby opioids, immune cells and cytokines dynamically interact [83][84][85]. The central immunologic receptors include µ-opioid receptor, DOR, DOR-antagonist, k-opioid receptor and k-opioid receptor-antagonist [86][87][88].…”

Section: Opioid-induced Immunologic Effectsmentioning

confidence: 99%

Opioids in chronic noncancer pain

Manchikanti

Benyamin

Datta

et al. 2010

Expert Review of Neurotherapeutics

View full text Add to dashboard Cite

“…Naloxone slightly, though not significantly, reduced the antibody response in intact rats on Day 51 (Fig. 4A,B), suggesting that endogenous opioid peptides might tonically regulate immune responses (Radulović and Janković, 1994).…”

Section: Discussionmentioning

confidence: 88%

Stress Applied During Primary Immunization Affects the Secondary Humoral Immune Response in the Rat: Involvement of Opioid Peptides

Stanojević

Dimitrijević

Kovačević-Jovanović

et al. 2003

Stress

Self Cite

View full text Add to dashboard Cite

The effect of unpredictable, inescapable and uncontrollable electric tail shocks (ES) on the humoral immune response to bovine serum albumin (BSA) was investigated in the rat. Contributions of the procedures that accompany shock delivery, such as witnessing the ES procedure (stress witnessing, SW) and exposure to the apparatus for shock delivery (apparatus control, AC) to the changes in specific immunity induced by ES were also tested. All procedures were applied during primary and/or secondary immunization. It was demonstrated that exposure to ES during primary immunization with BSA significantly suppressed specific anti-BSA antibody production after secondary and tertiary immunization with the same antigen. Exposure to the SW procedure during primary immunization with BSA enhanced the specific antibody level after secondary immunization, while exposure to the apparatus alone did not influence the development of either the primary or secondary humoral immune response to BSA. Both ES-induced suppression and SW-induced potentiation of the humoral immune response were partially inhibited by prior treatment with the opioid receptor antagonist naloxone. Additionally, treatments with the opioid peptides methionine- and leucine-enkephalin decreased anti-BSA antibody level, mimicking to some extent the effects of ES. It is suggested that ES and endogenous opioid peptides had long-term effects on humoral immunity through mechanisms involving immunologic memory.

show abstract

Opposing activities of brain opioid receptors in the regulation of humoral and cell-mediated immune responses in the rat

Cited by 30 publications

References 34 publications

Opioid Therapy and Immunosuppression

Opioid Therapy and Immunosuppression

Opioids in chronic noncancer pain

Stress Applied During Primary Immunization Affects the Secondary Humoral Immune Response in the Rat: Involvement of Opioid Peptides

Contact Info

Product

Resources

About