Opportunities for Molecular Imaging in Multiple Sclerosis Management: Linking Probe to Treatment

Thomas, Adrian; Barkhof, Frederik; Bulte, Jeff W.M.

doi:10.1148/radiol.211252

Cited by 5 publications

(2 citation statements)

References 121 publications

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“…Such observation supports the assumption that neurodegenerative processes in these clinical conditions are driven by divergent pathological pathways. However, this area definitely needs to be further investigated with more advanced diagnostic tools allowing for molecular assessment of myelin and/or axonal pathology [54,55]. We also found that CCI was significantly lower in MS compared with SDCNS patients.…”

Section: Discussionmentioning

confidence: 71%

Differences in Brain Atrophy Pattern between People with Multiple Sclerosis and Systemic Diseases with Central Nervous System Involvement Based on Two-Dimensional Linear Measures

Siger,

Wydra,

Wildner

et al. 2024

JCM

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Conventional brain magnetic resonance imaging (MRI) in systemic diseases with central nervous system involvement (SDCNS) may imitate MRI findings of multiple sclerosis (MS). In order to better describe the MRI characteristics of these conditions, in our study we assessed brain volume parameters in MS (n = 58) and SDCNS (n = 41) patients using two-dimensional linear measurements (2DLMs): bicaudate ratio (BCR), corpus callosum index (CCI) and width of third ventricle (W3V). In SDCNS patients, all 2DLMs were affected by age (CCI p = 0.005, BCR p < 0.001, W3V p < 0.001, respectively), whereas in MS patients only BCR and W3V were (p = 0.001 and p = 0.015, respectively). Contrary to SDCNS, in the MS cohort BCR and W3V were associated with T1 lesion volume (T1LV) (p = 0.020, p = 0.009, respectively) and T2 lesion volume (T2LV) (p = 0.015, p = 0.009, respectively). CCI was associated with T1LV in the MS cohort only (p = 0.015). Moreover, BCR was significantly higher in the SDCNS group (p = 0.01) and CCI was significantly lower in MS patients (p = 0.01). The best predictive model to distinguish MS and SDCNS encompassed gender, BCR and T2LV as the explanatory variables (sensitivity 0.91; specificity 0.68; AUC 0.86). Implementation of 2DLMs in the brain MRI analysis of MS and SDCNS patients allowed for the identification of diverse patterns of local brain atrophy in these clinical conditions.

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Section: Discussionmentioning

confidence: 71%

Differences in Brain Atrophy Pattern between People with Multiple Sclerosis and Systemic Diseases with Central Nervous System Involvement Based on Two-Dimensional Linear Measures

Siger,

Wydra,

Wildner

et al. 2024

JCM

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show abstract

“…Proton Magnetic Resonance Spectroscopy ( 1 H-MRS) and Positron Emission Tomography (PET) may contribute neurochemical information of inflammation, demyelination, neurodegeneration, oxidative stress and excitotoxicity to structural MRI using concentrations of metabolites to detect effects of disease-modifying treatments (Narayanan et al, 2001;Comi et al, 2012;Thomas et al, 2022). Despite recent innovations, advanced imaging techniques need to be further optimized to become precise and objective outcome measures in clinical trials.…”

Section: B Paraclinical Outcome Measures 1magnetic Resonance Imagingmentioning

confidence: 99%

Novel and Emerging Treatments to Target Pathophysiological Mechanisms in Various Phenotypes of Multiple Sclerosis

Bsteh,

Dal Bianco,

Zrzavy

et al. 2024

Pharmacol Rev

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A Chromium-Based magnetic resonance probe for in situ gastric pH imaging

Xu,

Yang,

et al. 2024

Chemical Engineering Journal

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Opportunities for Molecular Imaging in Multiple Sclerosis Management: Linking Probe to Treatment

Cited by 5 publications

References 121 publications

Differences in Brain Atrophy Pattern between People with Multiple Sclerosis and Systemic Diseases with Central Nervous System Involvement Based on Two-Dimensional Linear Measures

Differences in Brain Atrophy Pattern between People with Multiple Sclerosis and Systemic Diseases with Central Nervous System Involvement Based on Two-Dimensional Linear Measures

Novel and Emerging Treatments to Target Pathophysiological Mechanisms in Various Phenotypes of Multiple Sclerosis

A Chromium-Based magnetic resonance probe for in situ gastric pH imaging

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