Opportunities and Strategies for Breast Cancer Prevention Through Risk Reduction

Mahoney, Martin C.; Bevers, Therese B.; Linos, Eleni; Willett, Walter C.

doi:10.3322/ca.2008.0016

Cited by 82 publications

(68 citation statements)

References 164 publications

(127 reference statements)

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“…We had no information regarding lifestyle factors such as alcohol consumption, physical activity, or dietary habits that might be associated with the risk of depression as well as possibly breast cancer in the partner due to shared lifestyle. 38,39 The fact that these potential confounding factors were not taken into account might have resulted in an overestimation of the true effect. This study focused only on the partners of breast cancer patients, because we had access to detailed clinical information for this group of patients on a nationwide and population-based basis.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of severe depression in male partners of women with breast cancer

Nakaya

Saito-Nakaya

Bidstrup

et al. 2010

Cancer

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BACKGROUND: A few small studies published to date have suggested that major psychosocial problems develop in the partners of cancer patients; however, to the authors' knowledge, no studies to date have addressed their risk for severe depression. In a retrospective cohort study, the risk for hospitalization with an affective disorder of the male partners of women with breast cancer was investigated, using unbiased, nationwide, population-based information. METHODS: Followed were 1,162,596 men born between 1925 and 1973 who were aged 30 years at study entry, resided in Denmark between 1994 and 2006, had no history of hospitalization for an affective disorder, and had lived continuously with the same partner for at least 5 years. A Cox regression analysis included detailed clinical information regarding the diagnosis and treatment of breast cancer and on annually updated socioeconomic and healthrelated indicators obtained from national administrative and disease registers. RESULTS: During the 13 years of follow-up, breast cancer was diagnosed in the partners of 20,538 men. On multivariable analysis, men whose partner was diagnosed with breast cancer were found to be at an increased risk of being hospitalized with an affective disorder (hazards ratio, 1.39; 95%confidence interval, 1.20-1.61), with a dose-response pattern for the severity of breast cancer. Furthermore, men whose partner died after breast cancer had a significant, 3.6-fold increase in risk for an affective disorder when compared with men whose partner survived breast cancer. CONCLUSIONS: The results of the current study supported the hypothesis that men whose partner had breast cancer were at an increased risk for hospitalization with an affective disorder. Cancer 2010;116:5527-34.

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Section: Discussionmentioning

confidence: 99%

Increased risk of severe depression in male partners of women with breast cancer

Nakaya

Saito-Nakaya

Bidstrup

et al. 2010

Cancer

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“…BREAST CANCER IS the second most common malignancy after lung cancer and the most common cancer in women (1,2). Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive imaging technique increasingly used in breast cancer diagnosis as an adjunct to conventional imaging techniques (3,4).…”

mentioning

confidence: 99%

Performance of a fully automatic lesion detection system for breast DCE‐MRI

Vignati

Giannini

Luca

et al. 2011

Magnetic Resonance Imaging

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Purpose: To describe and test a new fully automatic lesion detection system for breast DCE-MRI.Materials and Methods: Studies were collected from two institutions adopting different DCE-MRI sequences, one with and the other one without fat-saturation. The detection pipeline consists of (i) breast segmentation, to identify breast size and location; (ii) registration, to correct for patient movements; (iii) lesion detection, to extract contrast-enhanced regions using a new normalization technique based on the contrast-uptake of mammary vessels; (iv) false positive (FP) reduction, to exclude contrastenhanced regions other than lesions. Detection rate (number of system-detected malignant and benign lesions over the total number of lesions) and sensitivity (systemdetected malignant lesions over the total number of malignant lesions) were assessed. The number of FPs was also assessed.Results: Forty-eight studies with 12 benign and 53 malignant lesions were evaluated. Median lesion diameter was 6 mm (range, 5-15 mm) for benign and 26 mm (range, 5-75 mm) for malignant lesions. Detection rate was 58/65 (89%; 95% confidence interval [CI] 79%-95%) and sensitivity was 52/53 (98%; 95% CI 90%-99%). Mammary median FPs per breast was 4 (1st-3rd quartiles 3-7.25). Conclusion:The system showed promising results on MR datasets obtained from different scanners producing fatsat or non-fat-sat images with variable temporal and spatial resolution and could potentially be used for early diagnosis and staging of breast cancer to reduce reading time and to improve lesion detection. Further evaluation is needed before it may be used in clinical practice.

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“…It is estimated that 184,450 new cases of invasive breast cancer were diagnosed in the United States in 2008 (1). Of all the breast cancer cases, 5%-7% are familial, and mutations in BRCA1 and BRCA2 account for the majority of familial breast cancers (2,3).…”

Section: Introductionmentioning

confidence: 99%

Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations

Chang

Biswas²,

Martin³

et al. 2009

J. Clin. Invest.

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To date, inheritance of a mutant BRCA1 or BRCA2 gene is the best-established indicator of an increased risk of developing breast cancer. Sequence analysis of these genes is being used to identify BRCA1/2 mutation carriers, though these efforts are hampered by the high frequency of variants of unknown clinical significance (VUSs). Functional evaluation of such variants has been restricted due to lack of a physiologically relevant assay. In this study we developed a functional assay using mouse ES cells to study variants of BRCA1. We introduced BAC clones with human wild-type BRCA1 or variants into Brca1-null ES cells and confirmed that only wild-type and a known neutral variant rescued cell lethality. The same neutral variant was also able to rescue embryogenesis in Brca1-null mice. A test of several BRCT domain mutants revealed all to be deleterious, including a VUS. Furthermore, we used this assay to determine the effects of BRCA1 variants on cell cycle regulation, differentiation, and genomic stability. Importantly, we discovered that ES cells rescued by S1497A BRCA1 exhibited significant hypersensitivity after γ-irradiation. Our results demonstrate that this ES cell-based assay is a powerful and reliable method for analyzing the functional impact of BRCA1 variants, which we believe could be used to determine which patients may require preventative treatments.

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Opportunities and Strategies for Breast Cancer Prevention Through Risk Reduction

Cited by 82 publications

References 164 publications

Increased risk of severe depression in male partners of women with breast cancer

Increased risk of severe depression in male partners of women with breast cancer

Performance of a fully automatic lesion detection system for breast DCE‐MRI

Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations

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