Opportunistic infections in a patient with HIV and thymoma

Leathers, Carrie A.; Azar, Marwan M.; Badve, Sunil; Roth, Trenton D.; Loehrer, Patrick J.; Nelson, Robert P.

doi:10.1016/j.jaip.2013.03.017

Cited by 1 publication

(4 citation statements)

References 9 publications

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“…Same as previously reported cases, a normal CD4+ count and a low CD4+/CD8+ ratio were observed in our patient. 7,8 A shift from memory/effector to naïve phenotype in CD4+ cells and abnormalities in CD8+ cells were found in our patient's peripheral T-cell repertoire. We conclude that with two immunocompromising conditions added, absolute CD4+ counts may not reflect the risk faced by patients.…”

Section: Discussionmentioning

confidence: 72%

“…A previous case reported a HIV and thymoma patient with Kaposi sarcoma and severe opportunistic infections but without T-cell lymphopenia. 8 Although our patient has no complications so far, abnormalities in T-cell subpopulation partially reveal his immune system dysfunction. Same as previously reported cases, a normal CD4+ count and a low CD4+/CD8+ ratio were observed in our patient.…”

Section: Discussionmentioning

confidence: 72%

“…To the best of our knowledge, four prior cases of thymoma with HIV infection have been reported, of which three were well-described (Table 1). [5][6][7][8] This comorbidity affected both adults and children, and patients of this kind were speculated to be more prone to opportunistic infections. 7,8 Together with our patient, several common features are found in these cases.…”

Section: Introduction and Brief Review Of Hiv And Thymoma Coexistencementioning

confidence: 99%

“…[5][6][7][8] This comorbidity affected both adults and children, and patients of this kind were speculated to be more prone to opportunistic infections. 7,8 Together with our patient, several common features are found in these cases. First, thymoma was discovered after HIV in all cases, which fits the definition of HIV-associated cancer.…”

Section: Introduction and Brief Review Of Hiv And Thymoma Coexistencementioning

confidence: 99%

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Type B thymoma in a patient with HIV infection: A case report with a review of HIV and thymoma coexistence

et al. 2021

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HIV infection predisposes people to cancer, including AIDS-defining cancers, such as Kaposi sarcoma, and a broad range of non-AIDS-defining cancers. Here we report a case with rare coexistence of HIV and thymoma, and summarize all the comorbid cases that currently exist. We found that in all the cases reported, thymoma occurred when CD4+ counts were within a normal range, but the immune response in peripheral T-cell repertoire remains unknown. In our case, an overview of the immune system under this complicated situation is given for the first time by showing the lymphocyte subpopulations in the blood and the immune cell distribution of the thymoma. This case expands the scope of non-AIDS-defining cancers, and provides insight into the influence of the immune system under two immunocompromising conditions, HIV infection and thymoma.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 72%