Opportunistic Fungal Infections with Particular Reference of Candida albicans*

Seeliger, H. P. R.

doi:10.1111/j.1439-0507.1976.tb01415.x

Cited by 7 publications

(9 citation statements)

References 8 publications

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“…Candida albicans and Candida spp. recovered from this study are known opportunistic organisms and may have caused infection in these inmates whose immunological status has been reduced due to unfavourable conditions of the prison 25 …”

Section: Discussionmentioning

confidence: 91%

“…recovered from this study are known opportunistic organisms and may have caused infection in these inmates whose immunological status has been reduced due to unfavourable conditions of the prison. 25 We recommend occasional screening of prison inmates for not only fungal skin infections but also infections caused by other organisms and prompt treatment of such infections should be incorporated into Health care delivery scheme of the government to reduce the suffering of the prisoners.…”

Section: Discussionmentioning

confidence: 99%

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Fungal skin infections among prison inmates in Abakaliki, Nigeria

Oyeka

Eze

2007

Mycoses

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SummaryOf 402 prison inmates screened for fungal skin lesions, 79 (19.7%) showed skin lesions, which proved mycologically positive by microscopy and culture. Dermatophytes were responsible for skin lesions in 61 (77.2%) of the inmates, while non-dermatophytes accounted for 18 (22.8%) of the lesions. The dermatophytes recovered were mostly anthropophilic and included Trichophyton rubrum 33 (41.8%); T. mentagrophytes var. interdigitale 3 (3.8%); T. tonsurans 3 (3.8%); T. violaceum 2 (2.5%); Epidermophyton floccosum 10 (12.7%). A zoophilic dermatophyte, Microsporum canis, was recovered from 10 (12.7%) cases. The non-dermatophytes were Candida albicans 15 (19%) and Candida spp. 3 (3.8%). Trichophyton rubrum was the most frequently recovered dermatophyte (41.8%) and caused infections in a variety of sites. The groin was the most common site of infection being infected in 50% of the cases by both the dermatophytes and non-dermatophytes. Younger inmates (17-24 years) recorded the highest prevalence of infection (45.6%). Newer inmates (>2 years) were found to be more infected than older ones.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Fungal skin infections among prison inmates in Abakaliki, Nigeria

Oyeka

Eze

2007

Mycoses

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“…The organism usually exists as a harmless commensal, but has the potential to become invasive, infectious, and even fatal by targeting numerous organ systems (1,2). As other pathogens, C. albicans relies on its host for micronutrients, such as metals, and the bioavailability of metals can greatly vary at the host-pathogen interface.…”

mentioning

confidence: 99%

Candida albicans adapts to host copper during infection by swapping metal cofactors for superoxide dismutase

Gleason

Zhang

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

100

150

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Copper is both an essential nutrient and potentially toxic metal, and during infection the host can exploit Cu in the control of pathogen growth. Here we describe a clever adaptation to Cu taken by the human fungal pathogen Candida albicans. In laboratory cultures with abundant Cu, C. albicans expresses a Cu-requiring form of superoxide dismutase (Sod1) in the cytosol; but when Cu levels decline, cells switch to an alternative Mn-requiring Sod3. This toggling between Cu- and Mn-SODs is controlled by the Cu-sensing regulator Mac1 and ensures that C. albicans maintains constant SOD activity for cytosolic antioxidant protection despite fluctuating Cu. This response to Cu is initiated during C. albicans invasion of the host where the yeast is exposed to wide variations in Cu. In a murine model of disseminated candidiasis, serum Cu was seen to progressively rise over the course of infection, but this heightened Cu response was not mirrored in host tissue. The kidney that serves as the major site of fungal infection showed an initial rise in Cu, followed by a decline in the metal. C. albicans adjusted its cytosolic SODs accordingly and expressed Cu-Sod1 at early stages of infection, followed by induction of Mn-Sod3 and increases in expression of CTR1 for Cu uptake. Together, these studies demonstrate that fungal infection triggers marked fluctuations in host Cu and C. albicans readily adapts by modulating Cu uptake and by exchanging metal cofactors for antioxidant SODs.

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“…In den letzten Jahren ist die Zahl der Sprosspilzvulvovaginitiden im Anstieg begriffen. Besonders haufig wurden sie bei der Anwendung oraler Kontrazeptiva beobachtet (2,5,13,14). Infektionen mit Candida albicans nach der Einnahme von Ovulationshemmern werden der Wirkung der Gestagene zugeschrieben.…”

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“…Infektionen mit Candida albicans nach der Einnahme von Ovulationshemmern werden der Wirkung der Gestagene zugeschrieben. Die Erhohung des Glykogengehaltes der vaginalen Mukosa, die gesteigerte Wasseraufnahme der Schleimhautzellen und die Verschiebung des pH-Wertes der Scheide nach der alkalischen Seite hin konnen durch gestagene Hormone ausgelost werden (3,5,12,13,14). Die Arbeitsgruppe um Wiechert, die die Struktur-Wirkungsbeziehungen von 40 Antiandrogenen untersuchten fanden Cyproteron und Cyproteronacetat aIs am starksten Antiandrogen wirksam ( 1 7).…”

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