Opisthorchis viverrini and Strongyloides stercoralis mono- and co-infections: Bayesian geostatistical analysis in an endemic area, Thailand

Suwannatrai, Apiporn; Thinkhamrop, Kavin; Suwannatrai, Kulwadee; Pratumchart, Khanittha; Wangdi, Kinley; Kelly, Matthew; Restrepo, Angela Cadavid; Gray, Darren J.; Clements, Archie C. A.; Tangkawattana, Sirikachorn; Sripa, Banchob

doi:10.1016/j.actatropica.2021.106079

Cited by 7 publications

(6 citation statements)

References 47 publications

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“…Certain demographic and socioeconomic factors (being male, being older, having education level lower than primary school and a history of alcohol intake) were significantly associated with S . stercoralis infection risk, similar to previous findings in Thailand [ 22 , 23 ] and other countries [ 33 , 34 ]. These same demographic and socioeconomic factors are commonly known to predispose people to infection and to reduce the efficiency of the immune response [ 35 ].…”

Section: Discussionsupporting

confidence: 91%

“…These locations were selected according to previous reports indicating a high prevalence of S . stercoralis infection [ 22 , 23 ]. A total 1039 participants from these communities were enrolled to participate in this study.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we aimed to investigate the association between S . stercoralis infection and T2DM in Khon Kaen Province, Thailand, where a high prevalence of infection has been reported [ 22 – 24 ]. We also extended the analysis to assess the interaction between S .…”

Section: Introductionmentioning

confidence: 99%

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Association of Strongyloides stercoralis infection and type 2 diabetes mellitus in northeastern Thailand: Impact on diabetic complication-related renal biochemical parameters

et al. 2022

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Background Several studies have demonstrated that helminth infections provide a degree of protection against Type 2 diabetes mellitus (T2DM). However, the relationship between Strongyloides stercoralis infection and T2DM has scarcely been investigated and the protective effect of infection against development of diabetic complications is unclear. In this study, we aimed to investigate the relationship between S. stercoralis infection and T2DM in a rural area of Khon Kaen Province, Thailand. The impact of S. stercoralis infection on diabetic complication-related kidney function biochemical parameters and body-mass index (BMI) was also assessed. Methodology Using a cross-sectional study design, S. stercoralis infection and T2DM assessments were conducted between October 2020 and May 2021. Associations between S. stercoralis infection, T2DM, and socioeconomic factors were analyzed using multivariable logistic regression analyses. Diabetic complication-related biochemical parameters relating largely to kidney function (estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (UACR), serum creatinine, uric acid, alanine transaminase (ALT), and low-density lipoprotein cholesterol (LDL-C)) and BMI of participants with and without T2DM were compared between groups with or without S. stercoralis infection. Results One hundred and seven out of 704 individuals (15.20%) were positive for S. stercoralis, and 283 people were diagnosed with T2DM. Of those with T2DM, 11.31% (32/283) were infected with S. stercoralis and of those without T2DM, 17.82% (75/421) were infected with S. stercoralis. Multivariate analysis revealed that T2DM was inversely correlated with S. stercoralis infection (Adjusted OR = 0.49; 95% CI: 0.30, 0.78; p = 0.003), while male, increasing age, lower education level, and alcohol intake were positively associated with infection. Those infected with S. stercoralis had lower eGFR levels and higher ALT and UACR levels than those in the uninfected group. Conclusion This finding indicates that S. stercoralis infection was inversely associated with T2DM in northeastern Thailand, but participants infected with S. stercoralis had lower eGFR levels and higher ALT and UACR levels. Infection with S. stercoralis might lead to worse complication-related renal biochemical parameters.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

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Association of Strongyloides stercoralis infection and type 2 diabetes mellitus in northeastern Thailand: Impact on diabetic complication-related renal biochemical parameters

et al. 2022

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“…Concentratedly, the top five highest prevalence subdistricts are located in the area which nearby the lakes, canals, river, and rivulets. It corresponds to previous reports that the humidity and water reservoirs are the main contributors to the parasite life cycle [34][35][36][37][38]. Even the occupations in our study were not different among the parasite positive and negative populations, but normally, the people in this area are doing other activities such as fishing for the rest of the year after finishing the rice farming season might be increased the risk of infection as well.…”

Section: Discussionsupporting

confidence: 88%

“…For the epidemiological findings, our present study found that gender is insignificantly related to parasitic infection in this area. However, the males have a higher risk than females (6.39 and 5.47%, respectively) which corresponded to several previous studies [19,38,49]. However, this finding suggested that gender is not only the factor contributing high risk of parasitic infection, especially in the endemic areas where the consumption behavior between male and female are not different.…”

Section: Discussionsupporting

confidence: 87%

Current prevalence and geographic distribution of helminth infections in the parasitic endemic areas of rural Northeastern Thailand

et al. 2023

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Background Helminth infection is a global health issue that not only causes acute helminthiasis but long-term infection may lead to complicated symptoms as well as severe complications. The World Health Organization cooperated with the Ministry of Public Health in many countries, particularly where high prevalence, spending a lot of resources for limiting the infection. In Thailand, the incidence of parasitic helminth infections was continuously declined in the last few decades according to several campaigns for parasitic elimination. However, the rural community in the northeast of Thailand where the highest prevalence of the country still needs to be monitored. This present study aims to report the current prevalence of parasitic helminth infections in Nakhon Ratchasima and Chaiyaphum provinces where sharing a huge area of the northeastern region of Thailand but only a few studies have been published. Methods The stool specimens were collected from 11,196 volunteers and processed by modified Kato-Katz thick smear, PBS-ethyl acetate concentration techniques, and PCR. The epidemiological data were collected, analyzed, and used for generating of parasitic hotspots. Results The results indicated that O. viverrini remains the major parasite in this area with a total prevalence of 5.05% followed by Taenia spp., Hookworms, T. trichiura, and Echinostoma spp., respectively. Mueang district of Chaiyaphum province has the highest prevalence especially O. viverrini with a prevalence of 7.15% that higher than the latest national surveillance. Interestingly, the prevalence of O. viverrini was hugely reported (more than 10%) in five subdistricts. The geographic localization of O. viverrini infections revealed that a lot of water reservoirs such as the lakes or branches of the river in the two-most prevalent subdistricts. Our finding indicated that gender and age were insignificantly different. Conclusion This finding suggested that the parasitic helminth infection in the rural areas of northeast of Thailand remains high and the housing location is a major contributing factor for the parasitic infection.

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Helminthic diseases: Foodborne trematode infections

Suwannatrai,

Sripa

2024

Reference Module in Biomedical Sciences

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Opisthorchis viverrini and Strongyloides stercoralis mono- and co-infections: Bayesian geostatistical analysis in an endemic area, Thailand

Cited by 7 publications

References 47 publications

Association of Strongyloides stercoralis infection and type 2 diabetes mellitus in northeastern Thailand: Impact on diabetic complication-related renal biochemical parameters

Association of Strongyloides stercoralis infection and type 2 diabetes mellitus in northeastern Thailand: Impact on diabetic complication-related renal biochemical parameters

Current prevalence and geographic distribution of helminth infections in the parasitic endemic areas of rural Northeastern Thailand

Helminthic diseases: Foodborne trematode infections

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