Opioids in Exercise Physiology

Cumming, David C.; Wheeler, Garry D.

doi:10.1055/s-2007-1021865

Cited by 16 publications

(4 citation statements)

References 38 publications

(55 reference statements)

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“…Questions arise as to the identity of "β-endorphin" [3,18,30,35] determined in all of those studies referred to above. There are at least 10 β-endorphin derivatives known to exist in the mammalian organism, β-endorphin (1 -27), (1 -26), (1 -17), and (1 -16), as well as their N-acetylated forms, and in addition N-acetyl-β-endorphin (1 -31) and further N-terminally elongated β-endorphin derivatives such as β-lipotropin (β-LPH) [11,30,37].…”

Section: Discussionmentioning

confidence: 99%

“…The hypothalamic-pituitary-adrenal axis can be activated by a variety of stress situations leading to the release of proopiomelanocortin (POMC) fragments from the pituitary into the cardiovascular compartment [15,16,18,36]; accordingly the release of POMC fragments such as ACTH or β-endorphin under exercise conditions has been frequently reported [3,6,8,19,24,25,28]. However, whereas ACTH is well known to stimulate corticoid release from the adrenal gland, the functional significance of β-endorphin in peripheral tissues still remains to be clarified.…”

Section: Introductionmentioning

confidence: 99%

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β-Endorphin Immunoreactive Material and Authentic β-Endorphin in the Plasma of Males Undergoing Anaerobic Exercise on a Rowing Ergometer

Schulz¹,

Harbach²,

Katz³

et al. 2000

Int J Sports Med

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Adrenocorticotropic hormone (ACTH), beta-endorphin immunoreactive material (beta-endorphin IRM), and authentic beta-endorphin (1 -31) have been determined in the plasma of 23 volunteers undergoing anaerobic exercise on a rowing ergometer. The volunteers had different histories of training from occasional physical activities up to intensive preparation for international rowing competitions. ACTH and beta-endorphin-IRM were determined using commercially available immunometric assays; for determination of beta-endorphin (1-31) a highly specific two-site fluid phase immunoprecipitation radioimmunoassay was developed, which did not cross-react with any beta-endorphin derivative or any other opioid peptide tested. In agreement with reports from the literature ACTH and beta-endorphin-IRM concentrations in the plasma rose upon anaerobic exercise in all 23 subjects; this increase in the ACTH and beta-endorphin IRM levels was significantly correlated with the increase of lactate levels observed upon anaerobic exercise. Authentic beta-endorphin (1-31) was only found in two plasma samples containing minor concentrations of the peptide. We conclude that the beta-endorphin immunoreactive material released into blood under anaerobic exercise is identical with authentic beta-endorphin (1-31) only to a minor extent and thus should not be called "beta-endorphin". The major part of the material in fact released into the blood upon anaerobic exercise is probably identical with beta-lipotropin and further components so far unknown.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

β-Endorphin Immunoreactive Material and Authentic β-Endorphin in the Plasma of Males Undergoing Anaerobic Exercise on a Rowing Ergometer

Schulz¹,

Harbach²,

Katz³

et al. 2000

Int J Sports Med

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“…The physiologic elevation of cortisol can occur secondary to exercise, hypoglycemia or stress (5). Acute exercise and training may influence circulating endogenous opioid (EO) levels (6). In addition to having an effect on exercise performance, EO may play a role in various hormonal changes.…”

mentioning

confidence: 99%

Is the Thoroughbred race-horse under chronic stress?

Nogueira

Barnabé

1997

Braz J Med Biol Res

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Thoroughbred fillies were divided into three groups according to age: group 1, 7 fillies aged 1 to 2 years (G1) starting the training program; group 2, 9 fillies aged 2 to 3 years (G2) in a full training program; group 3, 8 older fillies 3 to 4 years of age (G3) training and racing. Blood samples were collected weekly from July to December. Cortisol was quantified using a solid phase DPC kit. The intra-and interassay coefficients of variation were 12.5% and 15.65% and sensitivity was 1.9 ± 0.2 nmol/ l. The semester average of cortisol levels varied between groups: G1 = 148.8 ± 6.7, G2 = 125.7 ± 5.8, G3 = 101.1 ± 5.4 nmol/l, with G3 differing statistically from the other groups. The lower cortisol levels observed in the older fillies leads us to propose that the stress stimulus, when maintained over a long period of time, may become chronic and result in a reduction of hypophyseal corticotropin-releasing hormone receptors. The secretion of endogenous opioids may also lead to low serum cortisol levels.

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“…Previous studies of the relationship between exercise and climacteric symptoms have suggested the effectiveness of exercise on these symptoms (Cumming & Wheeler, 1987; Hammer et al. , 1990; Wilbur et al.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal study of a health education program for Japanese women in menopause

Matsuda

Okano

Suenaga

2009

Nursing & Health Sciences

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In this longitudinal intervention study, a 6 week health education program consisting of lectures and exercises was implemented for 39 Japanese menopausal women. The effects of the program were assessed by measuring their exercise participation, climacteric symptoms, and quality of life immediately before, 6 weeks after, and 1 year after the program. The Simplified Menopausal Index was used to assess the climacteric symptoms and the Medical Outcomes Study 36-Item Short-Form Health (SF-36) Survey was used to assess the quality of life. Significant improvements were observed in the subscale score for general health perception and the summary score for the physical component summary in the SF-36 Survey. Favorable results also were found for women without a previous exercise habit before the program but who participated in regular exercise 1 year after the program. No improvements were observed in the climacteric symptoms. We concluded that our program was effective for menopausal women in spite of the intervention period being relatively short.

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Opioids in Exercise Physiology

Cited by 16 publications

References 38 publications

β-Endorphin Immunoreactive Material and Authentic β-Endorphin in the Plasma of Males Undergoing Anaerobic Exercise on a Rowing Ergometer

β-Endorphin Immunoreactive Material and Authentic β-Endorphin in the Plasma of Males Undergoing Anaerobic Exercise on a Rowing Ergometer

Is the Thoroughbred race-horse under chronic stress?

Longitudinal study of a health education program for Japanese women in menopause

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