Opioids for hedonic experience and dopamine to get ready for it

Barbano, M. Flavia; Cador, Martine

doi:10.1007/s00213-006-0521-1

Cited by 214 publications

(152 citation statements)

References 109 publications

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“…Suggestions have included motivational incentive salience, arousal, motivation, and memory consolidation (Barbano and Cador 2007;Berridge 2007;Niv et al 2007;Redgrave and Gurney 2006;Robbins and Everitt 2007;Salamone et al 2007). If so, long-term plasticity in limbic structures, such as synaptic LTP and LTD, might reflect enduring motivation changes amongst other things rather than represent new learned associations via Hebbian synaptic coupling or prediction computation.…”

Section: Dopamine-beyond Learning Too?mentioning

confidence: 99%

Affective neuroscience of pleasure: reward in humans and animals

2008

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Introduction Pleasure and reward are generated by brain circuits that are largely shared between humans and other animals. Discussion Here, we survey some fundamental topics regarding pleasure mechanisms and explicitly compare humans and animals. Conclusion Topics surveyed include liking, wanting, and learning components of reward; brain coding versus brain causing of reward; subjective pleasure versus objective hedonic reactions; roles of orbitofrontal cortex and related cortex regions; subcortical hedonic hotspots for pleasure generation; reappraisals of dopamine and pleasure-electrode controversies; and the relation of pleasure to happiness.

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Section: Dopamine-beyond Learning Too?mentioning

confidence: 99%

Affective neuroscience of pleasure: reward in humans and animals

2008

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“…This functional brain network consists of structures such as the amygdala (Gilbert et al, 2003), the insular cortex (Desgranges et al, 2009;Roman et al, 2009) or the parabrachial nucleus (Reilly, 1999;Reilly and Trifunovic, 2000), which are involved in the establishment of a feeding preference or aversion, depending on the sensorial stimuli involved. Literature data also report 'hedonic hotspots' distributed in different brain structures such as the nucleus accumbens (Baldo and Kelley, 2007;Barbano and Cador, 2007;Pritchett et al, 2010), the ventral pallidum (Berridge, 2009) or the subthalamic nucleus (Baunez et al, 2002). The ventral striatum (i.e.…”

Section: Neurobiological Similaritiesmentioning

confidence: 99%

“…It is well acknowledged today that the dopamine and opioid systems play an important role in the modulation of feeding behaviour, although they are involved in different steps of this process. These two systems, which are important for the 'reward circuit' and play a major role in food pleasure and selection, have been relatively well characterized in humans and rats (Berridge, 2000;Kelley et al, 2002;Barbano and Cador, 2007;Barbano et al, 2009;Wassum et al, 2009) but not yet in pigs.…”

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confidence: 99%

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Food preferences and aversions in human health and nutrition: how can pigs help the biomedical research?

Clouard

Meunier-Salaün

Val‐Laillet

2012

Animal

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The establishment of food preferences and aversions determines the modulation of eating behaviour and the optimization of food intake. These phenomena rely on the learning and memory abilities of the organism and depend on different psychobiological mechanisms such as associative conditionings and sociocultural influences. After summarizing the various behavioural and environmental determinants of the establishment of food preferences and aversions, this paper describes several issues encountered in human nutrition when preferences and aversions become detrimental to health: development of eating disorders and obesity, aversions and anorexia in chemotherapy-treated or elderly patients and poor palatability of medical substances and drugs. Most of the relevant biomedical research has been performed in rodent models, although this approach has severe limitations, especially in the nutritional field. Consequently, the final aim of this paper is to discuss the use of the pig model to investigate the behavioural and neurophysiological mechanisms underlying the establishment of food preferences and aversions by reviewing the literature supporting analogies at multiple levels (general physiology and anatomy, sensory sensitivity, digestive function, cognitive abilities, brain features) between pigs and humans.Keywords: pig, conditioned learning, eating behaviour, animal model, biomedical applications ImplicationsInvestigation of the behavioural and neurophysiological mechanisms of the establishment of food preferences and aversions can lead to important developments in the context of human nutrition and health. Because the rodent models are not always adequate in this field, there is a need to develop alternative experimental models. Pigs have numerous similarities with humans in terms of the physiology, anatomy, sensory sensitivity, cognitive abilities and brain functions. The aim of this paper is to promote the use of pigs for biomedical research in human nutrition. IntroductionFeeding is a complex behaviour, which can be described as 'the research and consumption of food and drink to maintain vital functions ' (Bellisle, 1999) and to 'fulfil the metabolic needs of the organism ' (Ferreira, 2004). Today, it is also well acknowledged that a high proportion of human food consumption in developed countries appears to be driven by pleasure (for a review, see Lowe and Butryn, 2007) and sociocultural influences. Food consumption is also involved in fundamental metabolic homeostasis regulation, as it controls the supply of energy and nutrients in the organism (Bellisle, 1999). According to Ferreira (2004), feeding behaviour implies that animals learn to consume high-energy foods and to avoid toxic foods. Establishment of food selection implies that, during its first experience with food, the organism memorizes the sensorial characteristics of the food (e.g. taste, odour, texture and visual cues) and the postingestive consequences of its ingestion, and associates these food characteristics with these consequences (Garcia et ...

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“…Enkephalins belong to the family of endogenous opioids and are involved in, e.g., reward/ motivation (Barbano and Cador 2007) and the regulation of the stress response (Drolet et al 2001). An involvement of the endogenous opioidergic system in the mediation of several symptoms of depression has long been discussed, and it has been shown that enkephalin catabolism inhibitors (RB101) induce antidepressant-like effects (Roques 2000).…”

Section: Paroxetine Enhances Preproenkephalin 1 (Penk1) Expressionmentioning

confidence: 99%

Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine

et al. 2008

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Introduction Monoamine-based antidepressants inhibit neurotransmitter reuptake within short time. However, it commonly takes several weeks until clinical symptoms start to resolve-indicating the involvement of effects distant from reuptake inhibition. Objective To unravel other mechanisms involved in drug action, a "reverse" pharmacological approach was applied to determine antidepressant-induced alterations of hippocampal gene expression. Materials and methodsThe behavioral response to longterm paroxetine administration of male DBA/2Ola mice was assessed by the forced swim test (FST), the modified hole board (mHB), and the dark/light box. Hippocampi of test-naive mice were dissected, and changes in gene expression by paroxetine treatment were investigated by means of microarray technology. Results and discussion Robust effects of paroxetine on passive stress-coping behavior in the FST were observed. Furthermore, anxiolytic properties of long-term antidepressant treatment could be identified in DBA mice in both, the mHB and dark/light box. Analysis of microarray results revealed a list of 60 genes differentially regulated by chronic paroxetine treatment. Preproenkephalin 1 and inhibin beta-A showed the highest level of transcriptional change. Furthermore, a number of candidates involved in neuroplasticity/neurogenesis emerged (e.g., Bdnf, Gfap, Vim, Sox11, Egr1, Stat3). Seven selected candidates were confirmed by in situ hybridization. Additional immunofluorescence colocalization studies of GFAP and vimentin showed more positive cells to be detected in long-term paroxetine-treated DBA mice. Conclusion Candidate genes identified in the current study using a mouse strain validated for its responsiveness to long-term paroxetine treatment add, in our opinion, to unraveling the mechanism of action of paroxetine as a representative for SSRIs.

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Opioids for hedonic experience and dopamine to get ready for it

Cited by 214 publications

References 109 publications

Affective neuroscience of pleasure: reward in humans and animals

Affective neuroscience of pleasure: reward in humans and animals

Food preferences and aversions in human health and nutrition: how can pigs help the biomedical research?

Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine

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